Prenatal exposure to nickel on pregnant Swiss albino mice and fetal development

Saini, Shivi; Nair, Neena; Saini, M. R.

doi:10.1080/02772248.2014.957483

Cited by 6 publications

(3 citation statements)

References 28 publications

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“…Taking into consideration that a regular reaty‐to‐eat sushi box contains 200–300 g of sushi and that sushi is not the only food product containing nickel, frequent sushi consumption might result in exceeding the established safety levels. Because orally administered nickel is hazardous for fetal development, including skeletal development, fetal weight or even mortality, pregnant women should be discouraged from sushi consumption. Although the nori contained high levels of Ni, relatively small amounts of nori in the final product suggest that nori was not the main source of nickel contamination in the sushi samples.…”

Section: Resultsmentioning

confidence: 99%

Heavy metal contamination, microbiological spoilage and biogenic amine content in sushi available on the Polish market

et al. 2017

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Sushi is not the source of high levels of biogenic amines even with high microbiological loads. Nevertheless, the high microbiological loads at the end of the shelf-life indicate that some processors might have problems with the distribution chain or implement a poor hygienic regime. Moreover as a result of possible risk associated with heavy metal contamination, the present study highlights the need to establish new regulations regarding the contamination of nori and sushi. © 2017 Society of Chemical Industry.

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Section: Resultsmentioning

confidence: 99%

Heavy metal contamination, microbiological spoilage and biogenic amine content in sushi available on the Polish market

et al. 2017

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“…The effects of nickel on developmental parameters in Swiss albino mice during the pre‐implantation period were investigated (Saini et al., 2014b). Nickel chloride hexahydrate was administered to pregnant females by gavage (46, 92, or 185 mg Ni/kg bw) during GD 0–5.…”

Section: Assessmentmentioning

confidence: 99%

Update of the risk assessment of nickel in food and drinking water

Schrenk¹,

Bignami²,

Bodin³

et al. 2020

EFS2

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The European Commission asked EFSA to update its previous Opinion on nickel in food and drinking water, taking into account new occurrence data, the updated benchmark dose (BMD) Guidance and newly available scientific information. More than 47,000 analytical results on the occurrence of nickel were used for calculating chronic and acute dietary exposure. An increased incidence of postimplantation loss in rats was identified as the critical effect for the risk characterisation of chronic oral exposure and a BMDL 10 of 1.3 mg Ni/kg body weight (bw) per day was selected as the reference point for the establishment of a tolerable daily intake (TDI) of 13 lg/kg bw. Eczematous flare-up reactions in the skin elicited in nickel-sensitised humans, a condition known as systemic contact dermatitis, was identified as the critical effect for the risk characterisation of acute oral exposure. A BMDL could not be derived, and therefore, the lowest-observed-adverse-effect-level of 4.3 lg Ni/kg bw was selected as the reference point. The margin of exposure (MOE) approach was applied and an MOE of 30 or higher was considered as being indicative of a low health concern. The mean lower bound (LB)/upper bound (UB) chronic dietary exposure was below or at the level of the TDI. The 95th percentile LB/UB chronic dietary exposure was below the TDI in adolescents and in all adult age groups, but generally exceeded the TDI in toddlers and in other children, as well as in infants in some surveys. This may raise a health concern in these young age groups. The MOE values for the mean UB acute dietary exposure and for the 95th percentile UB raises a health concern for nickel-sensitised individuals. The MOE values for an acute scenario regarding consumption of a glass of water on an empty stomach do not raise a health concern.

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“…However, a more detailed analysis of the GO terms in each cluster looking for non – overlapping (unique) annotations, revealed that in cluster 1, Nrf2 and NiSO 4 differentially clustered with proteins related to the development of the fetus and placenta. Regarding developmental toxicity, recent evidence supports that soluble Ni 2+ can affect organogenesis in vivo [44–46], although nowadays no substantial epidemiological evidence has demonstrated a causal link between NiSO 4 and developmental effects [9]. As a contact allergen, NiSO 4 poorly correlated with Keap1/Nrf2 expression during dendritic cell activation in vitro [47].…”

Section: Discussionmentioning

confidence: 99%

Nuclear factor erythroid 2 – related factor 2 and its relationship with cellular response in nickel exposure: a systems biology analysis

Jiménez-Vidal

Espitia-Pérez

Torres-Ávila

et al. 2019

BMC Pharmacol Toxicol

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BackgroundNickel and nickel-containing compounds (NCC) are known human carcinogens. However, the precise molecular mechanisms of nickel-induced malignant transformation remain unknown. Proposed mechanisms suggest that nickel and NCC may participate in the dual activation/inactivation of enzymatic pathways involved in cell defenses against oxidative damage, where Nuclear factor-erythroid 2 related factor 2 (Nrf2) plays a central role.MethodsFor assessing the potential role of proteins involved in the Nrf2-mediated response to nickel and NCC exposure, we designed an interactome network using the STITCH search engine version 5.0 and the STRING software 10.0. The major NCC-protein interactome (NCPI) generated was analyzed using the MCODE plugin, version 1.5.1 for the detection of interaction modules or subnetworks. Main centralities of the NCPI were determined with the CentiScape 2.2 plugin of Cytoscape 3.4.0 and main biological processes associated with each cluster were assessed using the BiNGO plugin of Cytoscape 3.4.0.ResultsWater-soluble NiSO4 and insoluble Ni3S2 were the most connected to proteins involved in the NCPI network. Nfr2 was detected as one of the most relevant proteins in the network, participating in several multifunctional protein complexes in clusters 1, 2, 3 and 5. Ontological analysis of cluster 3 revealed several processes related to unfolded protein response (UPR) and response to endoplasmic reticulum (ER) stress.ConclusionsCellular response to NCC exposure was very comparable, particularly concerning oxidative stress response, inflammation, cell cycle/proliferation, and apoptosis. In this cellular response, Nfr2 was highly centralized and participated in several multifunctional protein complexes, including several related to ER-stress. These results add evidence on the possible Ni2+ induced – ER stress mainly associated with insoluble NCC. In this scenario, we also show how protein degradation mediated by ubiquitination seems to play key roles in cellular responses to Ni.

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Prenatal exposure to nickel on pregnant Swiss albino mice and fetal development

Cited by 6 publications

References 28 publications

Heavy metal contamination, microbiological spoilage and biogenic amine content in sushi available on the Polish market

Heavy metal contamination, microbiological spoilage and biogenic amine content in sushi available on the Polish market

Update of the risk assessment of nickel in food and drinking water

Nuclear factor erythroid 2 – related factor 2 and its relationship with cellular response in nickel exposure: a systems biology analysis

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