Prenatal Earthquake Exposure and Midlife Uric Acid Levels Among Chinese Adults

Ji, Chunpeng; Li, Yanping; Cai, Jun; Shi, Jihong; Cheng, Feon W.; Li, Yuqing; Curhan, Gary C.; Wu, Shouling; Gao, Xiang

doi:10.1002/acr.22973

Cited by 8 publications

(8 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Table SI 11.3 shows data collected on the relationship between PS and offspring's glucose metabolism. Four studies on offspring's glucose and PS were identified in our review and all of them found no association between glucose and PS (negative life events, job strain and exposure to earthquake) [41,47,54,55]. We found only one study reporting on PS and insulin without significant assoaciations [41].…”

Section: Systematic Review On the Relationship Between Ps And Blood Pmentioning

confidence: 82%

“…In one study, the systolic pressure was significantly higher in the prenatal earthquake stress group compared to that in the control group, but no significant differences were found for diastolic pressure [55]. In the other study, prenatal exposure to the earthquake was not associated with systolic or diastolic blood pressure [47].…”

Section: Systematic Review On the Relationship Between Ps And Blood Pmentioning

confidence: 87%

“…1. Full text review yielded 24 publications for inclusion into the systematic review and meta-analyses [35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58]. The list of excluded studies with reasons for exclusion is available in SI 5.…”

Section: Eligible Studies and Characteristicsmentioning

confidence: 99%

“…We performed two separate meta-analyses for BMI and body fat datasets. Table 1 altogether with SI 6 illustrate the characteristics of the 19 included studies [35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,53,55,56,58]. Thirteen studies included a relatively similar amount of males and females.…”

Section: Figmentioning

confidence: 99%

See 3 more Smart Citations

Systematic review and meta-analysis on the relationship between prenatal stress and metabolic syndrome intermediate phenotypes

et al. 2019

View full text Add to dashboard Cite

Background Metabolic Syndrome (MetS) can be considered as a consequence of a complex interplay between genetic and environmental factors and can be influenced by changes in the environment early in life. Prenatal stress (PS) exposure likely represents an important adverse intrauterine environment that may impact the biology of the developing organism. The aim of this study was to quantitatively synthesize the available data on the effects of PS on offspring's obesity, estimated indirectly by body mass index (BMI) and body fat; blood pressure, plasma glucose and blood lipid concentrations (triglycerides and high-density lipoprotein cholesterol).

show abstract

Section: Systematic Review On the Relationship Between Ps And Blood Pmentioning

confidence: 82%

Section: Systematic Review On the Relationship Between Ps And Blood Pmentioning

confidence: 87%

Section: Eligible Studies and Characteristicsmentioning

confidence: 99%

Section: Figmentioning

confidence: 99%

See 2 more Smart Citations

Systematic review and meta-analysis on the relationship between prenatal stress and metabolic syndrome intermediate phenotypes

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Such catastrophic natural disaster places tremendous stress on infants and developing fetuses. In our previous studies, we found that those who experienced Tangshan Earthquake in their early years had an increased risk of elevated resting heart rate, fasting plasma glucose, total cholesterol, higher serum uric acid and higher odds of hyperuricemia as adults (Ji et al, 2017; Li et al, 2017; An et al, 2014). We also found adverse neurocognitive consequences of long‐term prenatal earthquake exposure (Li et al, 2015).…”

Section: Introductionmentioning

confidence: 96%

The prevalence and risk of DSM‐IV axis I disorder in adults with early‐life earthquake stress: A cross‐sectional study

Song

Wang

Zhao

et al. 2019

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

Objectives Tangshan earthquake which had a magnitude of 7.8 killed approximately 250,000 people in China in 1976. In the present study, we sought to determine the prevalence and risks of mental disorders in adults who experienced earthquake as an infant or in the prenatal period. Methods This cross‐sectional cohort study recruited participants based on the urban resident registry of Tangshan, Hebei province, 2013 using a multistage stratified cluster sampling method with selection probabilities proportional to size. We recruited subjects who were born between July 29, 1975 and April 28, 1978 that was one year before and 1.9 years after the occurrence of Tangshan Earthquake, respectively. Current psychiatric diagnoses and lifetime psychiatric diagnoses were obtained through the Structured Clinical Interview for DSM‐IV Axis I Disorders Patient Research Version. Unconditional logistic regression analysis was performed to analyze risk factors of mental disorders. Results Totally1380 subjects were included with 392 subjects exposed to the earthquake in the fetal period, 399 subjects who experienced the earthquake during their infancy, and 589 subjects who had no exposure to the earthquake. Twenty‐one (2.7%; current 1.9%) subjects exposed to earthquake were diagnosed with major depressive disorderversus 2.3% (current 1.5%) in the non‐exposure group. Five (0.6%; current 0.6%) subjects with exposure to earthquake had bipolar disorder versus 0.9% in the non‐exposure group.Thirteen (1.6%; current 1.6%) subjects with exposure to earthquake had schizophreniaversus 0.2% in the non‐exposure group (P=0.006). Furthermore, 5.2% (current 3.7%) subjects with exposure to earthquake had anxiety disorders versus 5.7% (current 3.9%) in the non‐exposure group. Moreover, 8.1% (current 7.0%)subjects with exposure to earthquake had alcohol use disorders versus 7.1% (current 5.3%) in the non‐exposure group. Furthermore, the prevalence of schizophrenia of the prenatal exposure group (2.3%) was significantly higher than the other two groups (χ2 = 10.273, P = 0.006); however, no statistically significant difference was found in the current and lifetime prevalence of other DSM‐IV axis I disorders among the three groups (P > 0.05). Our multivariate regression analysis showed that prenatal earthquake stress exposure was not a significant risk of any of the lifetime or current DSD‐IV axis I disorders. Conclusion Adults who were exposed to earthquake in the prenatal period had a significantly higher rate of schizophrenia than those who were not exposed or who experienced earthquake in their infancy. No statistically significant difference was found in the current and lifetime prevalence of other DSM‐IV axis I disorders between those exposed and those not exposed to earthquake. Furthermore, prenatal earthquake stress exposure was not a significant risk of any of the lifetime or current DSD‐IV axis I disorders.

show abstract

Plasma urate concentrations and possible REM sleep behavior disorder

Shen

Schwarzschild

et al. 2019

Ann Clin Transl Neurol

View full text Add to dashboard Cite

ObjectiveTo examine how urate concentrations are related to the risk of having possible REM sleep behavior disorder (pRBD) in a community‐based cohort.MethodsThe study included 12,923 Chinese adults of the Kailuan Study, free of Parkinson disease (PD) and dementia. Plasma urate concentrations were measured in 2006, 2008, and 2010. Cumulative average urate concentration was used as primary exposure. In 2012, we determined pRBD status using a validated RBD questionnaire‐Hong Kong (RBDQ‐HK). Logistic regression analysis was performed to estimate the association between urate concentrations during 2006–2010 and odds of having pRBD in 2012 or pRBD case with symptom onset within 1 year.ResultsHigher average urate concentrations were associated with a lower odds of pRBD (P‐trend <0.001). The adjusted odds ratio (OR), for the highest versus lowest urate quintiles, was 0.43 (95% confidence intervals (CIs) 0.32–0.57). Significant association was consistently observed when we examined the association of a single urate assessment (2006 or 2010) or the rate of change in urate concentrations during 2006–2010 with pRBD (P‐trend <0.001 for all). However, restricting to pRBD onset during 2011–2012, we observed a nonsignificant trend between high urate concentration and high odds of pRBD (P‐trend = 0.09).InterpretationHigher average urate concentrations were associated with a lower likelihood of having pRBD, but not new‐onset pRBD. Because of its observational study design, the result should be interpreted with caution due to the possibility of residual confounding.

show abstract

Prenatal Earthquake Exposure and Midlife Uric Acid Levels Among Chinese Adults

Abstract: Prenatal exposure to the earthquake was associated with higher serum uric acid and higher odds of hyperuricemia in early adulthood.

Cited by 8 publications

References 24 publications

Systematic review and meta-analysis on the relationship between prenatal stress and metabolic syndrome intermediate phenotypes

Systematic review and meta-analysis on the relationship between prenatal stress and metabolic syndrome intermediate phenotypes

The prevalence and risk of DSM‐IV axis I disorder in adults with early‐life earthquake stress: A cross‐sectional study

Plasma urate concentrations and possible REM sleep behavior disorder

Contact Info

Product

Resources

About