Prenatal diagnosis of recurrent mosaic ring chromosome 13 of maternal origin

Chen, Chih‐Ping; Chen, Chen-Yu; Chern, Schu‐Rern; Chen, Shin-Wen; Wu, Fang-Tzu; Chen, Wenlin; Lee, Meng-Shan; Wang, Wayseen

doi:10.1016/j.tjog.2021.05.033

Cited by 2 publications

(3 citation statements)

References 8 publications

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“…21,22,24 However, the practice details of oxytocin administration markedly differ among facilities. 21,22,24 Hence, this study aimed to clarify the role of the “timing” of oxytocin administration in reducing blood loss during first-trimester suction curettage.…”

Section: Introductionmentioning

confidence: 99%

“…Although suction curettage is generally considered safe, it can cause significant morbidity and mortality when complications occur [17][18][19] and result in deterioration of women's reproductive health and possible economic or social problems. 20 Notably, pregnancies complicated by life-limiting malformations, such as trisomy 18 and 13, are frequently associated with placental abnormalities, [21][22][23][24][25] and excessive hemorrhage may also occur during suction curettage. Such cases should be treated with caution and managed appropriately if antenatally diagnosed.…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, unlike many reports, 14,15 intravenous (IV) oxytocin is widely administered during suction curettage in Taiwan. 21,22,24 However, the practice details of oxytocin administration markedly differ among facilities. 21,22,24 Hence, this study aimed to clarify the role of the "timing" of oxytocin administration in reducing blood loss during first-trimester suction curettage.…”

Section: Introductionmentioning

confidence: 99%

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The timing of intravenous oxytocin administration is crucial to minimize perioperative blood loss during first-trimester suction curettage for missed abortion

Yang

Chang

Chao

et al. 2022

Journal of the Chinese Medical Association

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Background: Oxytocin is commonly used to reduce blood loss during suction curettage for missed abortion. However, the potential of oxytocin to mitigate blood loss in early pregnancy remains controversial. Based on the hypothesis that the “timing” of oxytocin administration may be a critical factor, we investigated whether the timing of intravenous (IV) administration is associated with reduced perioperative blood loss during first-trimester suction curettage for missed abortion. Methods: The medical charts of 146 patients with ultrasound-confirmed first-trimester missed abortion who underwent suction curettage with IV oxytocin administration were retrospectively reviewed. Results: Among the patients, 67 received 10 IU of IV oxytocin before suction curettage (early-oxytocin administration group), while 79 patients received 10 IU of IV oxytocin after suction curettage (late-oxytocin administration group). The demographic features between the two groups did not significantly differ. However, there was a lower proportion of nulliparous patients in the early-oxytocin administration group than in the late-oxytocin administration group (38.8% vs 60.8%, p = 0.006). The perioperative blood loss amount was significantly lower in the early-oxytocin administration group than in the late-oxytocin administration group (60 [range: 50–100] vs 100 [range: 30–250] mL, p = 0.001). Moreover, the multivariate logistic regression analysis showed that the early-oxytocin administration group had a lower risk for a perioperative blood loss amount of ≥100 mL than the late-oxytocin administration group (0.23 [range: 0.10–0.55], p = 0.001); a gestational age of 9–12 weeks (p = 0.009) was found to be associated with an increased risk for a perioperative blood loss amount of ≥100 mL. Conclusion: Compared with late-oxytocin administration, early-oxytocin administration could reduce perioperative blood loss during first-trimester suction curettage for missed abortion. However, the results require further investigation.

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