Prenatal diagnosis of isolated non‐compaction of the ventricular myocardium: Study of six cases

Özkutlu, Süheyla; Bostan, Özlem; Karagöz, Tevfik; Deren, Özgür; Tekinalp, Gülsevin

doi:10.1111/j.1442-200x.2007.02339.x

Cited by 17 publications

(32 citation statements)

References 11 publications

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“…Three patients with "noncompaction" were diagnosed prenatally and the other 2 cases postnatally (11). The diagnosis of 3 cases with "noncompaction" and 2 -with rhabdomyoma were confirmed with postnatal echocardiography.…”

Section: Resultsmentioning

confidence: 93%

The results of fetal echocardiography in a tertiary center and comparison of low- and high-risk pregnancies for fetal congenital heart defects

Özkutlu¹,

Akça²,

Kafalı³

et al. 2010

Anadolu Kardiyol Derg

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Objective: Fetal echocardiography (FE) is considered for fetal, maternal or hereditary reasons in pregnants with suspect of intrauterine heart disease (IUHD). However, in few studies it was reported that most of the fetuses with IUHD are in the low-risk group (suspicion of IUHD during 2 nd trimester ultrasound, lack of good vision of the heart, self-referral). Our aim is to examine retrospectively the reasons for referral of pregnants, the results of FE, distribution of pregnants having fetuses with IUHD according to low-and high-risk factors and to evaluate reliability of FE. Methods: Our study group consisted of 1395 fetuses and 1370 pregnants underwent FE between 1999 and 2006. These cases included selfreferred women and the pregnants having previous child or family history of cardiac anomaly or referred by obstetricians. The prevalence of IUHDs in low-and high-risk pregnancies was compared by Chi-Square test. Results: The low risk group included 453 patients and the remaining 917 women were in the high-risk group. Intrauterine heart diseases were detected in 152 (10.9%) of 1395 fetuses. The prevalence of IUHDs was 19% in the low-risk group and 7% in the high-risk group. Of the152 fetuses 56.6% were in the low-risk group and 43.4% were in the high-risk group. The sensitivity of FE for diagnose of IUHDs was 97%, the specificity was 100%. Conclusion: Fetal echocardiography is highly reliable method for diagnosing of IUHDs. The most IUHDs occur in the low-risk group. (Anadolu Kardiyol Derg 2010; 10: 263-9) Key words: Fetal echocardiography, congenital heart disease, indication, low-risk and high-risk factors ÖZET Amaç: Fetal, maternal ve herediter nedenlerle FE yapılan gebeler, konjenital kalp hastalıklı (KKH) fetusa sahip olma olasılığı yüksek olan gebelerdir. Ancak yapılan çok az sayıdaki çalışmada KKH'lı fetusların çoğunun düşük riskli (ikinci trimester ultrasonunda KKH şüphesi, kalbin iyi görüntülene-memesi, gebelerin kendi istediğiyle başvurması) gebelik grubuna dahil olduğu bildirilmiştir. Bu çalışmada bölümümüzde son yıllarda FE'si yapılan gebelerin başvuru nedenlerini, ekokardiyografi sonuçlarını ve fetuslarında KKH'ı olan gebelerin düşük ve yüksek risk faktörlerine göre dağılımlarını ve FE sonuçlarımızın güvenilirliğini retrospektif olarak değerlendirdik. Yöntemler: Çalışmamızda Ekim 1999-Haziran 2006 tarihleri arasında Ünitemizde 1536 gebeye FE yapıldı. Postnatal ekokardiyografi sonucu bilinen 1243 normal kalp bulguları olan fetus ile postnatal ekokardiyografisi ve/veya otopsisi bilinen 152 intrauterin kalp hastalıklı (IUKH) fetus olmak üzere toplam 1395 fetus ve 1370 gebe çalışma grubumuzu oluşturdu. Bu olgular, kadın hastalıkları ve doğum uzmanları tarafından yönlendirilen, kendi isteğiyle başvuran ve ailesinde veya daha önceki gebeliklerinde KKH'ğı olan gebelerden oluşmaktadır. Düşük ve yüksek riskli gebelerdeki IUKH'ğı prevalansı Ki-Kare testiyle karşılaştırılmıştır. Bulgular: Düşük risk grubunda 453 (%33.1), yüksek risk grubunda 917 (%66.9) gebe yer almaktaydı. 1395 fetusun 152'sinde (%10.9) IUKH ...

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Section: Resultsmentioning

confidence: 93%

The results of fetal echocardiography in a tertiary center and comparison of low- and high-risk pregnancies for fetal congenital heart defects

Özkutlu¹,

Akça²,

Kafalı³

et al. 2010

Anadolu Kardiyol Derg

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“…In 85 cases, LVHT was diagnosed by fetal echocardiography and postnatally confirmed by either echocardiography or autopsy. In the remaining three cases, LVHT was diagnosed only postnatally, but review of the fetal echocardiograms disclosed that LVHT was visible but had been overlooked [35,38,43].…”

Section: Cases With Prenatal Diagnosis Of Lvhtmentioning

confidence: 99%

“…Before the year 2000, only one further report was published [62]. Between 2000 to 2009, 29 cases (33 %) were published [1,7,12,17,24,32,38,39,43,44,48,49]. Since 2010, 57 cases (65 %) were published [3,4,14,28,30,41,45,47,52,55,57,58,60].…”

Section: Cases With Prenatal Diagnosis Of Lvhtmentioning

confidence: 99%

“…The majority of the cases (n = 49, 56 %) were reported from hospitals in the USA [1,3,4,7,12,17,24,30,35,38,57,58]. Nine cases were reported from China [52], eight cases from Canada [60], five cases from France [39,62], five cases from Turkey [43], three cases form the UK [32,48], two cases each from Italy and the Netherlands [28,44,45] and one case each from Ireland, Greece, Portugal, Japan and Belgium [14,41,47,49,55]. The ethnicity is only reported in three cases of African origin [32,39,47].…”

Section: Cases With Prenatal Diagnosis Of Lvhtmentioning

confidence: 99%

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Fetal Ventricular Hypertrabeculation/Noncompaction: Clinical Presentation, Genetics, Associated Cardiac and Extracardiac Abnormalities and Outcome

2015

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Left ventricular hypertrabeculation/noncompaction (LVHT) is a cardiac abnormality of unknown etiology. Aim of the review was to summarize the current knowledge about fetal LVHT, including clinical presentation, associated cardiac and extracardiac abnormalities and outcome. In 88 cases, LVHT was diagnosed by fetal echocardiography. In 36 %, no additional cardiac abnormalities were reported; in the remaining 64 %, one or more cardiac abnormalities were reported. Eight cases died prenatally, 17 were electively terminated, and 24 patients died after birth. Six patients were lost to follow-up, and 33 patients are alive at a mean age of 26 months. Surviving cases presented less frequently with fetal hydrops (13 vs. 62 %, p = 0.0004), complete heart block (27 vs. 78 %, p = 0.0076), more than three associated cardiac abnormalities (9 vs. 47 %, p = 0.0008) and more frequently with isolated LVHT (52 vs. 19 %, p = 0.009) than cases who died. Of the surviving patients, 16 received pharmacotherapy, three received pacemakers, eight underwent surgical procedures and four underwent heart transplantation. Postnatal regression of left ventricular hypertrophy and development of LVHT was found in four cases, improvement in cardiac function in two, and regression of right VHT in two. At autopsy, endocardial fibrosis was the most frequent abnormality in 92 %. Thirty-eight percentage of cases with fetal LVHT survived. Fetal and postnatal echocardiographic findings challenge the "embryonic pathogenetic" hypothesis of LVHT. Furthermore, fetal pathoanatomic findings like endocardial fibrosis might play a role in clarifying the still unsolved pathogenesis of LVHT.

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“…kontraindikasjoner som pulmonal hypertensjon eller grunnliggende metabolsk sykdom. Muligheten for prenatal diagnostikk er beskrevet, men nytten av dette er sannsynligvis begrenset (9).…”

Section: Manglende Modning Av Ventrikkelmyokard Hos Barnunclassified

En 11 måneder gammel jente med gjentatte luftveisinfeksjoner

Holten-Andersen¹,

Sulheim²,

Indrebø³

et al. 2010

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Prenatal diagnosis of isolated non‐compaction of the ventricular myocardium: Study of six cases

Cited by 17 publications

References 11 publications

The results of fetal echocardiography in a tertiary center and comparison of low- and high-risk pregnancies for fetal congenital heart defects

The results of fetal echocardiography in a tertiary center and comparison of low- and high-risk pregnancies for fetal congenital heart defects

Fetal Ventricular Hypertrabeculation/Noncompaction: Clinical Presentation, Genetics, Associated Cardiac and Extracardiac Abnormalities and Outcome

En 11 måneder gammel jente med gjentatte luftveisinfeksjoner

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