Prenatal diagnosis and outcomes of fetal teratomas

Arısoy, Resul; Erdoğdu, Emre; Kumru, Pınar; Demirci, Oya; Ergin, Nida; Pekin, Oya; Şahinoğlu, Zeki; Tuğrul, Ahmet Semih; Sancak, Selim; Çetiner, Handan; Celayir, Ayşenur Cerrah

doi:10.1002/jcu.22310

Cited by 19 publications

(27 citation statements)

References 26 publications

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“…[1][2][3] The prognosis of these tumors especially depends on their size and location. 4,5 These tumors are usually large at the time of diagnosis because of their rapid development. 5 They occur in a para-axial or midline location from the brain to the sacral area, and in the gonads.…”

Section: Introductionmentioning

confidence: 99%

“…4,5 These tumors are usually large at the time of diagnosis because of their rapid development. 5 They occur in a para-axial or midline location from the brain to the sacral area, and in the gonads. Few cases are reported to survive in the perinatal period without postoperative complications.…”

Section: Introductionmentioning

confidence: 99%

“…Few cases are reported to survive in the perinatal period without postoperative complications. 3,[5][6][7] In thoracic location, the prognosis is usually poor because of the negative impact of these tumors on the growth and development of the heart and lungs. 2,4,6,8,9 They may cause neonatal respiratory distress, stillbirth, or frequently fetal hydrops by compressive effect on the heart and major vessels.…”

Section: Introductionmentioning

confidence: 99%

“…6,8,9 Ultrasonography is reported to have very high sensitivity and low false-positive rates in identifying fetal teratoma. 5 The thoracic teratomas, however, may be misinterpreted on prenatal ultrasound, being confused with congenital adenomatoid malformation of the lung, bronchogenic cysts, diaphragmatic hernia, or bronchopulmonary sequestration. 6,9 In the present case, we detailed the sonographic and pathological findings of a misinterpreted mediastinal teratoma detected at 23 weeks gestation and complicated by severe hydrops fetalis, posthemorrhagic hydrocephalus, and placental diffuse chorangiomatosis.…”

Section: Introductionmentioning

confidence: 99%

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Fetal mediastinal teratoma: Misinterpretation as congenital cystic lesions of the lung on prenatal ultrasound

Darouich

Bellamine

2019

J of Clinical Ultrasound

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Congenital mediastinal teratoma can lead to development of hydrops fetalis and may be misinterpreted on ultrasound. In this case report, ultrasound revealed severe fetoplacental hydrops, moderate posthemorrhagic hydrocephalus, and multiple pulmonary cysts suggesting cystic adenomatoid malformation and displacement of the heart to the left side. Autopsy of the hydropic 24-weeks male fetus showed a large cystic-solid mediastinal mass that was consistent with nonmetastatic immature teratoma. It also demonstrated thymic, cardiac and pulmonary hypoplasia, and confirmed the germinal matrix-intraventricular hemorrhage. Accurate prenatal diagnosis of mediastinal teratoma may be achieved by a careful Doppler ultrasound assessment that also allows evaluating the fetal outcome. K E Y W O R D S mediastinal teratoma, nonimmune hydrops fetalis, prenatal diagnosis, ultrasonography

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fetal mediastinal teratoma: Misinterpretation as congenital cystic lesions of the lung on prenatal ultrasound

Darouich

Bellamine

2019

J of Clinical Ultrasound

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“…The sacrococcygeal teratomas has the frequency of 75% and has high morbidity and mortality rates because of perinatal complications such as preterm birth, anemia, hydrops, fetal dead, dystocia, spontaneous tumor hemorrhage or rupture. The tumor on the head and neck area as a high risk of asphyxia due to the airway obstruction risk [3].…”

Section: Discussionmentioning

confidence: 99%

Immature Teratoma Involving Lung Tissue in a Newborn

Turgut¹,

Gkce²,

Akatlı³

et al. 2017

Diagn Pathol Open

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Sacrococcygeal teratoma, the most common fetal-neonatal neoplasia. While mature teratomas is having several well-differentiated mature tissues, immature teratomas consist of components that were not completely differentiated specific to the fetal tissue. Even though it might be seen that a several group of tissues such like bone, cartilage, skeleton muscle tissue, bowel and bronchiolar epithelium tissue inside the immature teratoma.We reported a newborn with sacrococcygeal mass which extended to gluteal region and at the right leg. In the histopathological study of the mass, immature cartilage and lung tissue were existed as well as grade III immature teratoma and immature neuroepithelial inside a tumor. We present a newborn case with big immature teratoma include lung tissue. Till now, lung tissue has not been reported in immature terotoma.

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Fetal teratomas – A retrospective observational single‐center study

et al. 2020

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Objective Evaluation of course and outcome of pregnancies with prenatally diagnosed fetal teratomas of various locations in a single center between 2002 and 2019. Methods Retrospective observational single‐center study including prenatally suspected or diagnosed fetal teratomas. Focus was put on ultrasound findings during pregnancy. Complications, need for intervention and outcomes were compared according to tumor location. Results 79 cases of fetal teratomas were seen at our center between 2002 and 2019. Most frequent tumor locations were the sacrococcygeal region (59.5%), neck (20.2%) and oropharynx (7.6%). Complications mainly included polyhydramnios and cardiac compromise. Need for intervention during pregnancy was significantly higher in pericardial teratomas. Preterm birth before 37 and early preterm birth before 32 weeks occurred in 72.7% and 29.1%, respectively. Major causes of perinatal death were tumor bleeding in sacrococcygeal teratomas (SCTs) and respiratory failure in cervical and oropharyngeal teratomas. Conclusion There is a high need for intervention in pregnancies complicated by fetal teratomas. Pericardiocentesis in pericardial teratomas is often inevitable to reduce the risk of intrauterine demise. Amniotic fluid drainage in associated severe polyhydramnios helps to reduce the risk of preterm birth, a major cause of additional morbidity and mortality. MRI in supplement to prenatal ultrasound is useful in fetal teratomas of the neck and oropharynx in order to plan delivery.

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Prenatal diagnosis and outcomes of fetal teratomas

Abstract: US has very high sensitivity and low false-positive rates in identifying fetal teratoma prenatally. The risk of chromosomal abnormalities is very low in fetuses with teratoma, and their prognosis depends on the location and size of the tumor and any associated perinatal complications.

Cited by 19 publications

References 26 publications

Fetal mediastinal teratoma: Misinterpretation as congenital cystic lesions of the lung on prenatal ultrasound

Fetal mediastinal teratoma: Misinterpretation as congenital cystic lesions of the lung on prenatal ultrasound

Immature Teratoma Involving Lung Tissue in a Newborn

Fetal teratomas – A retrospective observational single‐center study

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