Prenatal diagnosis and outcome of partial agenesis and hypoplasia of the corpus callosum

Ghi, T.; Carletti, Angela; Contro, E.; Cera, E.; Falco, Pietro; Tagliavini, Giovanna; Michelacci, Laura; Tani, Giovanni; Youssef, A.; Bonasoni, Maria Paola; Rizzo, Nicola; Pelusi, G.; Pilu, Gianluigi

doi:10.1002/uog.7489

Cited by 85 publications

(99 citation statements)

References 24 publications

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“…intracranial masses, obstructive hydrocephalus (Davila-Gutuerrez, 2002;Paupe et al, 2002) rather than a primary malformative abnormality.Thus, callosal hypoplasia more likely depends upon an external factor affecting the number and size of callosal axons. This is apparently confirmed by a experience since callosal hypoplasia was often associated with additional brain anomalies (Ghi et al, 2010). Hypoplasia and partial agenesis of the corpus callosum may occur in isolation form, in these conditions, neurological outcome is reported by some to be similar to that in cases with absent corpus callosum1 ( Moutard et al ,2003;Mordefroid et al, 2004;Ghi et al, 2010).…”

Section: Callosal Hypoplasiamentioning

confidence: 66%

“…This is apparently confirmed by a experience since callosal hypoplasia was often associated with additional brain anomalies (Ghi et al, 2010). Hypoplasia and partial agenesis of the corpus callosum may occur in isolation form, in these conditions, neurological outcome is reported by some to be similar to that in cases with absent corpus callosum1 ( Moutard et al ,2003;Mordefroid et al, 2004;Ghi et al, 2010). Callosal hypoplasia include a significant size reduction of the anterior genu, posterior genu (Walterfang, 2008, Walterfang, 2009aVidal et al, 2006;Just et al, 2007;Walterfang et al, 2009b;2009c), isthmus (Walterfang, 2008;Walterfang, 2009a;Vidal et al, 2006;Just et al, 2007;Cao et al, 2010)and the posterior midbody (Cao et al, 2010), a smaller splenium width (Bersani, 2010;Vidal et al, 2006;Just et al, 2007;Hutchinson et al ., 2008), a cyst in the splenium (Bamiou et al, 2007) and a smaller anterior midbody.…”

Section: Callosal Hypoplasiamentioning

confidence: 72%

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Brain Commissural Anomalies

Yousefi¹

2012

When Things Go Wrong - Diseases and Disorders of the Human Brain

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Section: Callosal Hypoplasiamentioning

confidence: 66%

Section: Callosal Hypoplasiamentioning

confidence: 72%

Brain Commissural Anomalies

Yousefi¹

2012

When Things Go Wrong - Diseases and Disorders of the Human Brain

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“…24 Isolated complete agenesis, however, seems to have a better prognosis than a partial or hypoplastic corpus callosum. 19 A recent meta-analysis of 27 studies on the outcome shows a higher proportion of chromosomal anomalies, more gross and fine motor control affection, and a higher percentage of epilepsy in the partial agenesis group compared with the complete agenesis of the CC group. 40 Today, diagnosis relies on a midtrimester sonographic examination potentially revealing Յ1of the associated signs such as mild ventriculomegaly, colpocephaly, absent cavum septi pellucidi, upward displacement of the third ventricle, teardrop configuration of the lateral ventricles, or cystic dilation of the third ventricle.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, dysgenesis of the corpus callosum could be reflected by a misshapen or abnormal course of the pericallosal arteries and their branches. [18][19][20] With this study, we aimed to document the normal longitudinal development and variants of the pericallosal vasculature from 11 to 22 weeks of gestation using power Doppler flow and high-frequency sonography probes.…”

Section: Aimmentioning

confidence: 99%

Sonographic Development of the Pericallosal Vascularization in the First and Early Second Trimester of Pregnancy

Keersmaecker

Pottel

Naulaers³

et al. 2018

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Anomalies of the corpus callosum are rare. Routine scanning in midtrimester of the pregnancy often fails to identify defective development. The purpose of the study was to identify the pericallosal artery and all its main branching arteries during early gestation from the first trimester onward, to measure the length of the pericallosal artery during its development, and to establish a normal vascular map for each week of development.

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“…Contudo, deve-se referir como principal limitação do plano médio sagital, a falta da clara diferenciação do CC em relação à porção inferior do septo pelúcido 6 . Além disso, os casos de hipoplasia e agenesia parcial do CC pela US2D são extremamente difíceis de serem realizados, porque apesar de o CC ser identificado com forma atípica, a forma da cabeça fetal no plano axial é frequentemente normal 7 .…”

Section: Introductionunclassified

Avaliação do comprimento e área do corpo caloso fetal por meio da ultrassonografia tridimensional

Visentainer

Júnior

Rôlo

et al. 2010

Rev. Bras. Ginecol. Obstet.

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Artigo originalResumo OBJETIVO: determinar os valores de referência para o comprimento e a área do corpo caloso fetal entre a 20 a e 33 a semanas de gestação por meio da ultrassonografia tridimensional (US3D). MÉTODOS: foi realizado um estudo do tipo corte transversal com 70 gestantes normais entre a 20 a e 33 a semanas de gestação. Utilizou-se um aparelho da marca Accuvix XQ, equipado com transdutor convexo volumétrico (3 a 5 MHz). Para a obtenção do corpo caloso fetal, foi utilizado um plano transfrontal, com a sutura metópica como janela acústica. Para o cálculo do comprimento, utilizou-se a distância entre os pontos médios dos polos proximal e distal do corpo caloso. Para o cálculo da área, a delimitação manual da superfície externa do corpo caloso foi realizada. Para o comprimento e a área do corpo caloso, foram calculadas: as médias, as medianas, os desvios padrão e os valores máximo e mínimo. Para a correlação da área e do comprimento do corpo caloso com a idade gestacional e o diâmetro biparietal foram criados diagramas de dispersão, sendo a qualidade dos ajustes verificada pelo coeficiente de determinação (R 2 ). Para a variabilidade intraobservador, utilizou-se o coeficiente de correlação intraclasse (CCI). RESULTADOS: a média do comprimento do corpo caloso variou de 21,7 mm (18,6 -25,2 mm) a 38,7 mm (32,6 -43,3 mm) entre a 20 a e 33 a semanas, respectivamente. A média da área do corpo caloso variou de 55,2 mm 2 (41,0 -80,0 mm 2 ) a 142,2 mm 2 (114,0 -160,0 mm 2 ) entre a 20 a e 33 a semanas, respectivamente. O comprimento e a área do corpo caloso foram fortemente correlacionados com a idade gestacional (R 2 = 0,7 e 0,7, respectivamente) e com o diâmetro biparietal (R 2 = 0,7 e 0,6, respectivamente). A variabilidade intraobservador foi adequada com CCI = 0,9 e 0,9 para o comprimento e área, respectivamente. CONCLUSÕES: valores de referência para o comprimento e área do corpo caloso fetal entre a 20 a e 33 a semanas foram determinados. A variabilidade intraobservador foi adequada.Abstract PURPOSE: to establish reference values for the length and area of the fetal corpus callosum between the 20 th and 33 rd weeks of gestation using three-dimensional ultrasound (3DUS). METHODS: this cross-sectional study involved 70 normal pregnancies with gestational age between 20 and 33 weeks. An Accuvix XQ instrument with a convex volumetric transducer (3 to 5 MHz) was used. To assess the corpus callosum, a transfrontal plane was obtained using the metopic suture as an acoustic window. Length was obtained by measuring the distance between the proximal and distal extremities of the corpus callosum. Area was obtained by manual tracing of the external corpus callosum surface. The means, medians, standard deviations, and maximum and minimum values were calculated for the corpus callosum length and area. Scatter graphs were created to analyze the correlation between corpus callosum length and area and gestational age and biparietal diameter, the quality adjustments was verified according to the determination coefficient (R...

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Prenatal diagnosis and outcome of partial agenesis and hypoplasia of the corpus callosum

Abstract: Objective To present antenatal sonographic findings and outcome of fetuses with hypoplasia or partial agenesis of the corpus callosum. Methods

Cited by 85 publications

References 24 publications

Brain Commissural Anomalies

Brain Commissural Anomalies

Sonographic Development of the Pericallosal Vascularization in the First and Early Second Trimester of Pregnancy

Avaliação do comprimento e área do corpo caloso fetal por meio da ultrassonografia tridimensional

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