Sonographic Development of the Pericallosal Vascularization in the First and Early Second Trimester of Pregnancy

Keersmaecker, B. De; Pottel, Hans; Naulaers, Gunnar; Catte, Luc De

doi:10.3174/ajnr.a5562

Cited by 8 publications

(10 citation statements)

References 41 publications

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“…Antenatal imaging earlier than or at 18–20 weeks (the usual timing of standard ultrasound screening) does not reliably detect total agenesis, partial agenesis, or hypoplasia of the corpus callosum (Bennett, Bromley, & Benacerraf, ). However, indirect ultrasound screening features that may indicate a corpus callosum anomaly include the absence of the cavum septi pellucidi, colpocephaly (dilatation of the atria and occipital horns of the lateral ventricles), high‐riding third ventricle, abnormal course of the pericallosal artery, widening of the interhemisphere fissure, and radial disposition of the sulci on the internal aspects of the hemispheres (De Keersmaecker, Pottel, Naulaers, & De Catte, ; Santo et al, ; Tang et al, ). Fetal magnetic resonance imaging which is clinically helpful in suspected cases of ACC because it can confirm that the corpus callosum is absent was performed in the cases of fetal ACC.…”

Section: Methodsmentioning

confidence: 99%

Associated anomalies in cases with agenesis of the corpus callosum

Stoll

Dott

Roth

2019

American J of Med Genetics Pt A

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Agenesis of corpus callosum (ACC) is an uncommon congenital anomaly, its etiology is unclear and its pathogenesis is controversial. Cases with ACC often have other non-ACC associated congenital anomalies. The purpose of this study was to assess the prevalence and the types of these associated anomalies in a defined population.The associated anomalies in cases with ACC were collected in all live births, stillbirths, and terminations of pregnancy during 29 years in 387,067 consecutive births in the area covered by our population-based registry of congenital malformations. Of the 99 cases with ACC, representing a prevalence of 2.56 per 10,000, 73 (73.7%) had associated anomalies. There were 16 (16.2%) cases with chromosomal abnormalities, and 13 (13.2%) nonchromosomal recognized dysmorphic conditions including syndromes two each: Aicardi, Dandy-Walker, and fetal alcoholism. Forty-four (44.4%) of the cases had nonsyndromic multiple congenital anomalies (MCA). Anomalies in the musculoskeletal, the urogenital, the central nervous, the cardiovascular, and the digestive systems were the most common other anomalies in the cases with MCA.The anomalies associated with ACC could be classified into a recognizable malformation syndrome in 29 out of the 73 cases (39.7%) with associated anomalies. This study included special strengths: it is population-based, each affected child was examined by a geneticist, all elective terminations were ascertained, and the surveillance for anomalies was continued until 2 years of age. In conclusion the overall prevalence of associated anomalies, three of four cases, emphasizes the need for a screening for other anomalies in cases with ACC. K E Y W O R D Sagenesis of corpus callosum, brain malformations, central nervous system anomalies, congenital anomalies, multiple congenital anomalies

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Section: Methodsmentioning

confidence: 99%

Associated anomalies in cases with agenesis of the corpus callosum

Stoll

Dott

Roth

2019

American J of Med Genetics Pt A

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“…These findings, however, are not always encountered in fetuses with partial agenesis, and become more evident after 24 weeks of gestation (Paladini et al, 2013). The course of the pericallosal artery, detected from 11 weeks of gestation has been considered an early sonographic marker of abnormal development of the corpus callosum (De Keersmaecker et al, 2018). In cases where fetal MRI was performed, 23% of cases presented additional intracranial anomalies, changing substantially the prognosis (Bell et al, 2015;Sotiriadis and Makrydimas, 2012).…”

Section: Introductionmentioning

confidence: 99%

Prevalence and associated factors for agenesis of corpus callosum in Emilia Romagna (1981–2015)

Ballardini

Marino

Maietti

et al. 2018

European Journal of Medical Genetics

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“…Moreover, worldwide differences in prevalence of congenital anomalies may be attributed to ethnic variations that affect mainly genetic causes of fetal malformations. Teratogenicity, environmental factors and family history also play a very important role in these variations among countries [19]. Also, the results vary according to the type and number of participants in each study and duration of assessment [20].…”

Section: Discussionmentioning

confidence: 99%

Predominance of fetal malformations among pregnant women: A multi-centric observational study

Sayed¹,

Khalifa²,

Shehata³

et al. 2021

Clin J Obstet Gynecol

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Objective: To observe the predominance of fetal anomalies in pregnant women in a multi-centric setting. Methods: This prospective observational study included 20225 pregnant women who came for antenatal care in University Hospital and fetal medicine units from 2016 to 2019. Fetal anatomical scanning was done for all participants. Results: One hundred eighty-three cases had fetal congenital anomalies, yielding a prevalence of around 0.9%. Third of cases had positive consanguinity, this increased in cases of skeletal and thoracic anomalies. The presence of past history of anomalies was evident in 8.2% mostly with skeletal and heart anomalies. History of drug intake was only verified in 1.6% of cases. Sixty-three women out of 183 (34.4%) were diagnosed to have anomalies in fetal nervous system. Conclusion: Prenatal diagnosis are recommended for early detection of congenital anomalies and counselling.

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Sonographic Development of the Pericallosal Vascularization in the First and Early Second Trimester of Pregnancy

Cited by 8 publications

References 41 publications

Associated anomalies in cases with agenesis of the corpus callosum

Associated anomalies in cases with agenesis of the corpus callosum

Prevalence and associated factors for agenesis of corpus callosum in Emilia Romagna (1981–2015)

Predominance of fetal malformations among pregnant women: A multi-centric observational study

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