Prenatal compensatory renal growth in unilateral renal agenesis

Perlman, Sharon; Lotan, Dani; Dekel, Benjamin; Kivilevitch, Z.; Hazan, Yinon; Achiron, Reuven; Gilboa, Y.

doi:10.1002/pd.4938

Cited by 4 publications

(6 citation statements)

References 27 publications

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“…Recently, compensatory hypertrophy was found in up to 88% of SFKs based on measurement of the kidney length . Perlman et al proposed a nomogram for renal length as a substitute for renal hyperplasia of SFK in fetuses with unilateral renal agenesis . In our study, we confirm this observation with 2D and 3D volume measurements.…”

Section: Discussionsupporting

confidence: 88%

“…29 Perlman et al proposed a nomogram for renal length as a substitute for renal hyperplasia of SFK in fetuses with unilateral renal agenesis. 30 In our study, we confirm this observation with 2D and 3D volume measurements. Compensatory hypertrophy is mostly seen as a physiological adaptation to the presence of only 1 functional kidney, and its absence is considered a less favorable sign for renal function at later age.…”

Section: Discussionsupporting

confidence: 87%

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Analysis of renal blood flow and renal volume in normal fetuses and in fetuses with a solitary functioning kidney

et al. 2017

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 87%

Analysis of renal blood flow and renal volume in normal fetuses and in fetuses with a solitary functioning kidney

et al. 2017

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“…Van Vuuren et al 13 reported compensatory enlargement (defined as renal length > 95th percentile for gestational age [GA]) in 87% of MCDK cases and 100% of unilateral renal agenesis cases. Finally, a previous study published by our group 14 reported a unique growth pattern for solitary kidneys due to unilateral renal agenesis from the early second trimester to term.…”

mentioning

confidence: 59%

“…The percentile of the mean length of the normal kidney contralateral to the MCDK was compared to data regarding the solitary kidney length and percentile throughout gestation 14 with repeated measures for the second and third trimesters as mentioned above. The normal kidney contralateral to the MCDK had a significantly different compensatory growth pattern from the compensatory growth pattern of the solitary kidney as published in the literature (Table 3 and Figure 3).…”

Section: Resultsmentioning

confidence: 99%

Multicystic Dysplastic Kidney

Gilad

Weissmann-Brenner

Gilboa

et al. 2020

J of Ultrasound Medicine

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Objectives To assess the prenatal growth pattern of the normal kidney contralateral to a multicystic dysplastic kidney (MCDK). Methods A retrospective study was conducted in a single referral center over 4 years. Cases diagnosed prenatally as MCDK and confirmed postnatally constituted the study group. For creation of nomograms, only isolated cases of MCDK were included. Results Sixty‐one fetuses had a diagnosis of an MCDK during the study period. After exclusion of cases with associated malformations, 47 fetuses remained, providing 94 measurements for creation of nomograms. The growth pattern of the normal kidney contralateral to an MCDK was linear throughout gestation (percentile = 20.01 + 1.5 gestational age; linear R2 = 0.753; r = 0.868) and was significantly higher during the third trimester (29–38 weeks' gestation) compared to the second trimester (22–28 weeks' gestation; P < .001). A comparison of the growth pattern of the normal kidney contralateral to the MCDK to the growth pattern of a solitary kidney revealed a significant higher compensatory trend during the third trimester (P < .0001). The mean kidney lengths at 22 and 38 weeks' gestation correlated with the 52nd and 88th and with the 84th and 90th percentiles for the normal kidney contralateral to the MCDK and a solitary kidney, respectively. Conclusions According to our study, the normal kidney contralateral to an MCDK has a unique growth pattern during intrauterine life, with dominant growth during the third trimester. The exact mechanism for this pattern, in comparison to early renal hypertrophy shown in solitary kidneys, is currently not clear. These data provide relevant information for the multidisciplinary prenatal counseling of future parents regarding the future renal outcome.

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“…Unilateral renal agenesis causes intra-uterine compensatory renal growth, which can affect postnatal renal function [27]. MCDK can also cause compensatory hypertrophy of solitary functioning kidneys in utero [28].…”

Section: Discussionmentioning

confidence: 99%

Renal growth slope in children with congenital and acquired solitary functioning kidneys

et al. 2021

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Purpose: This study aimed to analyze the renal growth slope in children with congenital and acquired solitary functioning kidneys. Methods: This retrospective study included all renal ultrasonography examinations performed in children in the agenesis, multicystic dysplastic kidney (MCDK), or nephrectomy group between September 2002 and February 2019. We reviewed the images and recorded the contralateral kidney size only when there was no focal lesion. Linear mixed model or piecewise linear mixed model analyses with a time point of 24 months of age were performed. Results: There were 132 patients, including 26 patients in the agenesis group, 35 in the MCDK group, and 71 in the nephrectomy group. The nephrectomy group showed the largest baseline kidney size (7.4 cm vs. 5.3 cm in the agenesis group [P<0.001] and 5.2 cm in the MCDK group [P<0.001]) and the smallest overall growth slope (0.04 cm/mo vs. 0.06 cm/mo in the agenesis group [P=0.004] and 0.07 cm/mo in the MCDK group [P<0.001]). However, considering the time point of 24 months for reaching adult renal function, there were significant changes in slope, from 0.1 cm/mo before 24 months of age to 0.03 cm/mo after 24 months of age in all three groups (P<0.001), without a significant difference among the groups. Conclusion: Significant changes were found in the renal growth slope before and after 24 months of age, with no significant difference between congenital and acquired solitary functioning kidneys.

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Prenatal compensatory renal growth in unilateral renal agenesis

Cited by 4 publications

References 27 publications

Analysis of renal blood flow and renal volume in normal fetuses and in fetuses with a solitary functioning kidney

Analysis of renal blood flow and renal volume in normal fetuses and in fetuses with a solitary functioning kidney

Multicystic Dysplastic Kidney

Renal growth slope in children with congenital and acquired solitary functioning kidneys

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