Analysis of renal blood flow and renal volume in normal fetuses and in fetuses with a solitary functioning kidney

Hindryckx, An; Raaijmakers, Anke; Levtchenko, Elena; Allegaert, Karel; Catte, Luc De

doi:10.1002/pd.5167

Cited by 3 publications

(4 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Assessment of the renal parenchyma and renal growth are the most important because they provide an estimate of renal functional reserve. Hindryckx et al 8 . found that the kidneys were larger in children with solitary renal function.…”

Section: Discussionmentioning

confidence: 98%

Ability of volume measures of hydronephrosis to predict need for surgery and evaluate renal function in children with ureteropelvic junction obstruction

et al. 2021

View full text Add to dashboard Cite

Objective To explore the efficacy of quantitative renal volume measures on magnetic resonance urography images in predicting need for surgery among children with ureteropelvic junction obstruction and their ability to evaluate renal function. Methods A total of 88 cases of hydronephrosis in 50 patients were collected between 1 April 2018 and 31 March 2020, including 30 operated kidney and 58 unoperated kidney cases. Clinical data were collected, and quantitative analysis of magnetic resonance urography was performed. Renal volume, hydronephrosis volume and the volume ratio of hydronephrosis (hydronephrosis volume/renal volume) were measured and calculated. We analyzed the relationships between the above indices in the two groups and compared these with renal function. Results Compared with the unoperated kidney group, hydronephrosis volume, renal volume and hydronephrosis volume/renal volume of the operated kidney group increased significantly. Hydronephrosis volume (area under the curve 0.972, 95% confidence interval 0.943–1.000; P < 0.001) and hydronephrosis volume/renal volume (area under the curve 0.968, 95% confidence interval 0.939–0.998; P < 0.001) were superior to ultrasonography and renal function examination in predicting the probability of surgery, and their sensitivity values (hydronephrosis volume/renal volume: 96.67%; hydronephrosis volume: 93.33%) were higher than those of the renal function test (50%). There was a significant difference among different renal function groups in the pairwise comparison of hydronephrosis volume and hydronephrosis volume/renal volume (P < 0.05). Conclusion Quantitative volume measures of hydronephrosis by magnetic resonance urography had a greater ability to predict need for surgery than ultrasonography and dynamic renal imaging, and it can be used as method by which to evaluate surgery. Hydronephrosis volume and hydronephrosis volume/renal volume have greater predictive ability, and play an important role in the deterioration of renal function.

show abstract

Section: Discussionmentioning

confidence: 98%

Ability of volume measures of hydronephrosis to predict need for surgery and evaluate renal function in children with ureteropelvic junction obstruction

et al. 2021

View full text Add to dashboard Cite

show abstract

“…There are a limited number of studies investigating normal fetal renal artery blood flow, and most have small sample sizes, are cross-sectional in design and have heterogeneous inclusion and exclusion criteria making direct comparison difficult. [12][13][14][15][16][17] Some earlier studies showed that the PI decreased with increasing GA. 12,13 The study most similar to our study, in that it was a longitudinal design and used mixed effects modelling, also demonstrated that the RI and PI remained relatively unchanged throughout the pregnancy. 16 Other studies demonstrated similar findings; however, these were not longitudinal in design.…”

Section: Discussionmentioning

confidence: 99%

“…[12][13][14][15][16][17] Some earlier studies showed that the PI decreased with increasing GA. 12,13 The study most similar to our study, in that it was a longitudinal design and used mixed effects modelling, also demonstrated that the RI and PI remained relatively unchanged throughout the pregnancy. 16 Other studies demonstrated similar findings; however, these were not longitudinal in design. 14,15 A study in 2015 reported longitudinal reference intervals for fetal renal arteries, however was not truly longitudinal as although the design was longitudinal, the data were not analysed as longitudinal data.…”

Section: Discussionmentioning

confidence: 99%

Fetal renal artery blood flow – Normal ranges

et al. 2021

View full text Add to dashboard Cite

Introduction The study objectives were to develop standard charts for fetal renal artery blood flow to define normal ranges and to assess the reliability of the measurements. Methods This prospective, longitudinal study reviewed 72 low-risk singleton pregnancies who had serial ultrasound examinations. Pulse wave Doppler was used to obtain the resistivity and pulsatility indices of the fetal renal arteries. Standard charts of the fetal renal arteries were created using mixed effects modelling and the intra- and interobserver reliability for the renal blood flow measurements was analysed. Results Standard charts of the normal ranges of the renal artery resistive index (RI) and pulsatility index (PI) of the fetal renal arteries were created. The 3rd, 5th, 10th, 50th, 90th, 95th and 97th centiles were calculated. The intraclass correlation coefficient was acceptable for intraobserver reliability (RI = 0.66, PI = 0.88) and poor for interobserver reliability (RI = 0.11, PI = −0.56). Conclusions These novel charts demonstrate the change of the fetal renal artery blood flow during pregnancy. These may be used in clinical practice to detect variations from these normal ranges and be useful in future studies of kidney function projection.

show abstract

“…Under normal physiological conditions, the kidney volume of patients who underwent unilateral nephrectomy signi cantly increased postoperatively [13]. Similarly, the volume of solitary functioning kidney was notably larger compared to that of healthy kidney [14]. The increase in kidney volume is to improve renal function to meet the needs of metabolism and toxin excretion.…”

Section: Sensitivity Analysismentioning

confidence: 99%

Genetically supported causality between kidney volume and kidney stones: A mendelian randomization study

Xu,

Huang,

Jin

et al. 2024

Preprint

View full text Add to dashboard Cite

Purpose The association between kidney volume and the risk of kidney stones is unclear. Thus, we conducted a two-sample Mendelian randomization (MR) analysis to identify this association. Methods Single nucleotide polymorphisms (SNPs) associated with kidney volume were obtained from publicly available genome-wide association study (GWAS) data. Inverse-variance weighted (IVW), MR-Egger, and weighted median (WM) methods were performed to assess the causal relationship between kidney volume and the risk of kidney stones. Additionally, horizontal pleiotropy and heterogeneity were detected using MR-Egger and Cochran’s Q test. Results The results of the IVW method (pooled OR: 2.90 95% CI: 1.910–4.410, P < 0.001) revealed a positive causal association between kidney volume and the risk of kidney stones. Conclusion Our study provided genetic support that an increase in kidney volume may raise the risk of kidney stones.

show abstract

Analysis of renal blood flow and renal volume in normal fetuses and in fetuses with a solitary functioning kidney

Abstract: Low PSV RA might have a predictive value for diagnosing a nonfunctioning kidney in fetuses with a SFK. We demonstrated a higher PSV RA and larger renal volume in the SFK compared with healthy kidneys.

Cited by 3 publications

References 36 publications

Ability of volume measures of hydronephrosis to predict need for surgery and evaluate renal function in children with ureteropelvic junction obstruction

Ability of volume measures of hydronephrosis to predict need for surgery and evaluate renal function in children with ureteropelvic junction obstruction

Fetal renal artery blood flow – Normal ranges

Genetically supported causality between kidney volume and kidney stones: A mendelian randomization study

Contact Info

Product

Resources

About