Prenatal Chlamydia trachomatis infection increases the risk of preeclampsia

Haggerty, Catherine L.; Klebanoff, Mark A.; Panum, Inge; Uldum, Søren A.; Bass, Debra C.; Olsen, Jørn; Roberts, James M.; Ness, Roberta B.

doi:10.1016/j.preghy.2013.03.002

Cited by 25 publications

(16 citation statements)

References 24 publications

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“…We conducted a nested case control study of 208 singleton and primiparous preeclamptic women and 411 singleton and primiparous normotensive controls within the Collaborative Perinatal Project (CPP) [19]. Both cases and controls had no history of diabetes, cardiovascular disease or hypertension.…”

Section: Methodsmentioning

confidence: 99%

First and second trimester immune biomarkers in preeclamptic and normotensive women

Taylor

Ness

Klebanoff

et al. 2016

Pregnancy Hypertension: An International Journal of Women's Car

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Introduction Circulating immune markers may be associated with preeclampsia but further investigations in early pregnancy and among preeclampsia subtypes are warranted. We examined immune markers in 208 preeclamptic women and 411 normotensive controls. Methods Our study was nested within the Collaborative Perinatal Project. A total of 242 women had first trimester serum samples and 392 had second trimester serum samples. Preeclampsia was defined as hypertension >20 weeks of gestation with proteinuria or pulmonary edema, oliguria, or convulsions. Preterm preeclampsia was defined as preeclampsia with delivery less than 37 weeks of gestation. Associations between immune markers RANTES, interleukin (IL)-6, IL4, IL5, IL12, IL10, IL8, IL1-beta, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha and beta, transforming growth factor (TGF)-beta and preeclampsia were explored using a modified version of cox regression developed to address data with non-detectable levels. Models were adjusted for body mass index, gestational age of blood sampling, fetal sex, smoking, socioeconomic status and maternal age. Results In first trimester samples, IL-12 was associated with preeclampsia (p=0.0255). IFN-gamma (p=0.0063), IL1-beta (p=0.0006), IL5 (p=0.0422) and TNFr (p=0.0460) were associated with preterm preeclampsia only. In second trimester samples, IL1-beta was associated with preeclampsia (p=0.0180) and term preeclampsia (p=0.0454). After correction for multiple comparisons, only IL1-beta remained associated with preterm preeclampsia in the first trimester (p=0.0288). Discussion Elevated first trimester IL1-beta appears to be associated with preterm preeclampsia. However, few associations were observed in the second trimester. Systemic immune markers alone may not be useful for preeclampsia prediction.

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Section: Methodsmentioning

confidence: 99%

First and second trimester immune biomarkers in preeclamptic and normotensive women

Taylor

Ness

Klebanoff

et al. 2016

Pregnancy Hypertension: An International Journal of Women's Car

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“…Placental DNA released into the circulation of the mother and the fetus (maternal circulation) could have a role in the characteristic inflammation involved with preeclampsia [14]. In studies that looked at the connection between maternal infection and preeclampsia, it was found that the risk of preeclampsia was increased in women with urinary tract infection and periodontal disease [15][16][17].…”

Section: Inflammation And/or Infectionmentioning

confidence: 99%

Preeclampsia: Pathophysiology and the Maternal-Fetal Risk

Khalil¹

2017

J Hypertens Manag

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“…34,35 This may be explained by the fact that the increased risk for developing preeclampsia in women with specific HLA-G alleles may be combined with CMV infection. 4 It has been stated that CMV infection impairs trophoblast differentiation and invasion. This leads in turn to down-regulate matrix metalloproteinase (MMP) activity in uterine micro vascular endothelial cells and differentiating invading cytotrophoblast.…”

Section: Discussionmentioning

confidence: 99%

“…The pathophysiology of the disease involves impaired trophoblast invasive, abnormal genetic polymorphism, vascular endothelial cell activation, immune tolerance by the maternal immune system and an exaggeration of a systematic inflammatory process. 1 Perturbation of the immune system is a central feature in the maternal generalized inflammatory response of preeclampsia; 2 among player microbial factors like Chlamydia pneumonia, 3 Chlamydia trachomatis, 4 Helicobacter pylori, 5 Human papillomavirus, 6 and cytokines like TNF-α, 7 IL-1, 8 IL-6, 9 IL-12, 10 IL-18, 11 and INF-γ 12 are thought to be involved in the pathogenesis of preeclampsia for a long time. 13,14 Data strongly focused on the alteration of the equilibration between TH1and TH2 lymphocytes in preeclamptic trophoblast, 15 in favor of an increase of TH1 profile with the consequence of defect in the expression of IL-2.…”

Section: Introductionmentioning

confidence: 99%

The possible role of cytomegalovirus infection and pro-inflammatory IL_2 cytokine in preeclampsia

Barzangy

Salh

Hamasaeed

et al. 2018

ZJMS

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IntroductionThe origin of preeclampsia, a hypertensive disorder unique to pregnancy is still a matter of debate and numerous theories have suggested. The pathophysiology of the disease involves impaired trophoblast invasive, abnormal genetic polymorphism, vascular endothelial cell activation, immune tolerance by the maternal immune system and an exaggeration of a systematic inflammatory process. Background and Objective: Fragmentary evidence suggests that trophoblast viral infection may play a role in placental dysfunction leading to complications like Preeclampsia. Among these, placental exposure to CMV induces an inflammatory response that precedes invasive trophoblast cell death. This study aimed to assess the frequency of anti-CMV IgG seropositivity and IL2 level in serum in patients with preeclampsia compared to normotensive control pregnant women. Methods: A total of 90 women were enrolled, of which 60 had preeclampsia and 30 normotensive pregnant women as the control. A serum sample was collected from each subject and was investigated for anti-CMV IgG serostatus and IL-2 concentration using Enzyme-Linked Immunosorbent Assay (ELISA) based kits. Results: In preeclamptic and normotensive pregnant women, 33.3% and 16.6% of the tested sera were seropositive for anti CMV IgG antibodies respectively (P = 0.136). Early onset preeclamptic women revealed a high frequency of anti-CMV seropositivity (80%) when compared with late onset Preeclampsia (20%). Cytokine assessment revealed a higher IL-2 level in preeclamptic women seropositive for anti-CMV IgG although statistically was not significant (P = 0.14), but in normotensive women, the IL-2 level was significantly higher in sera seropositive for anti-CMV IgG (P = 0.02). Conclusion: This study delineates a high frequency of anti-CMV IgG antibodies particularly those with early onset preeclampsia; with no significant difference for the IL-2 level.

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Prenatal Chlamydia trachomatis infection increases the risk of preeclampsia

Cited by 25 publications

References 24 publications

First and second trimester immune biomarkers in preeclamptic and normotensive women

First and second trimester immune biomarkers in preeclamptic and normotensive women

Preeclampsia: Pathophysiology and the Maternal-Fetal Risk

The possible role of cytomegalovirus infection and pro-inflammatory IL_2 cytokine in preeclampsia

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