Prenatal bisphenol A and birth outcomes: MOCEH (Mothers and Children's Environmental Health) study

Lee, Bo Eun; Park, Hyesook; Hong, Yun Chul; Ha, Mina; Kim, Yangho; Chang, Namsoo; Kim, Boong Nyun; Kim, Young Ju; Yu, Seung Do; Ha, Eun Hee

doi:10.1016/j.ijheh.2013.07.005

Cited by 120 publications

(78 citation statements)

References 49 publications

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“…39 Because exposure to BPA has been associated with change of birth weight 23,40 and increased weight in children, 41 the increase in BP might be the effect of changed birth weight or increase of weight. However, adjusting for current weight and birth weight in the present study did not diminish the significance of the association of BPA exposure at around 20 weeks of gestation with BP, suggesting that the association is independent from the weight-increasing effect of BPA.…”

Section: Discussionmentioning

confidence: 99%

“…39 Como la exposición a BPA se ha asociado con cambio del peso de nacimiento 23,40 y mayor peso en los niños, 41 el aumento de PA podría ser el efecto de la modificación del peso de nacimiento o del aumento de peso. Sin embargo, el ajuste por peso actual y peso de nacimiento en el presente estudio no disminuyó la significación de la asociación entre exposición a BPA alrededor de las 20 semanas de gestación y PA, lo que sugirió que la asociación es independiente del efecto de aumento de peso del BPA.…”

Section: Discussionunclassified

“…18 In humans, the association between prenatal exposure to BPA and health in early childhood has been reported. 10,13,[19][20][21][22][23][24] However, to the best of our knowledge, no study has examined the association between prenatal BPA exposure and BP in childhood.…”

Section: B Isphenol a (Bpa) Is An Endocrine-disrupting Chemicalmentioning

confidence: 99%

“…18 En los seres humanos, se ha comunicado asociación entre exposición prenatal a BPA y salud en la primera infancia. 10,13,[19][20][21][22][23][24] Sin embargo, hasta donde sabemos, ningún estudio ha explorado la Resumen-Se ha comunicado que el bisfenol A (BPA) se asocia con efectos adversos para la salud, incluida presión arterial (PA) alta.Asimismo, se sospecha que el BPA atraviesa la placenta durante el embarazo y podría afectar la salud de los niños. El presente estudio tuvo por objeto evaluar el efecto de la exposición prenatal a BPA sobre la PA del niño a los 4 años de edad.…”

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Maternal Urinary Bisphenol A Concentration During Midterm Pregnancy and Children’s Blood Pressure at Age 4

et al. 2017

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Abstract-Bisphenol A (BPA) has been reported to be associated with adverse health effects, including high blood pressure (BP). BPA is also suspected to cross placenta in pregnancy and might affect children's health. The present study was aimed to evaluate the effect of prenatal exposure to BPA on the BP of the child at the age of 4. We followed up 645 children at the age of 4 who were born from women who participated midterm during their pregnancy in a birth cohort study from August 2008 to July 2011. Because BPA and BP showed nonlinear association, we constructed a piecewise regression model to examine the association between urinary BPA concentration of mother at around 20 weeks of gestation and BP of the child at age 4 and to determine threshold level of BPA for the association. Diastolic BP of the children was positively associated with maternal urinary concentration of BPA above the threshold level measured at around 20 weeks of gestation. For 1 log unit increment of prenatal urinary BPA concentration, diastolic BP was increased by 7.9 mm Hg (SE=2.072; P=0.0001) after adjusting potential confounders. Pulse pressure was decreased by −8.0 mm Hg (SE=2.528; P=0.0015). However, systolic BP was not significantly associated with prenatal BPA concentration. The present study suggests that exposure to BPA during pregnancy is associated with higher diastolic BP of the children above a certain threshold (4.5 μg/g creatinine). intima media thickness of adults were positively associated with childhood BP. 26 In light of this, identifying and avoiding the risk factors of high BP in children may lead to prevention of cardiovascular diseases in adulthood.Based on the previous studies reporting associations between BPA exposure and BP in adults and between prenatal BPA exposure and childhood disease, we hypothesized that prenatal exposure of BPA may increase BP in children. In the present study, we aimed to examine the association between maternal urinary BPA concentration at around 20 weeks of gestation and the BP of 4-year-old children. MethodThe study protocol was reviewed and approved by the Institutional Review Board at College of Medicine, Seoul National University (1201-010-392), and informed consent was provided by each of the participants. The protocol was in accordance with the declaration of Helsinki and institutional guidelines. Study DesignEDC study (Environment and Development of Children) is a follow-up study of the CAS (Congenital Anomaly Study), a birth cohort to investigate the association between prenatal environmental exposure and occurrence of congenital anomaly. CAS consisted of pregnant women who received prenatal care at 8 hospitals in Seoul and Incheon metropolitan area, Republic of Korea. A total of 13 484 women were enrolled at around 20 weeks of gestation and 11 085 were followed up until they gave birth, from August 2008 to July 2011. At the time of enrollment of the mothers, blood and urine samples were collected after >8 hours of fasting, and a questionnaire regarding demographics and lifestyl...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionunclassified

Section: B Isphenol a (Bpa) Is An Endocrine-disrupting Chemicalmentioning

confidence: 99%

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Maternal Urinary Bisphenol A Concentration During Midterm Pregnancy and Children’s Blood Pressure at Age 4

et al. 2017

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“…When the liver is damaged they are released in the bloodstream [37]. GOT and GPT are commonly measured clinically as a marker for the liver function; thus the increased GOT and GPT activities in the liver tissue after exposure to BPA in 30 days indicated that gradual dose of BPA could lead to the liver function abnormality [38]. The marked decrease in the activity of -GT in BPA-treated rats indicates a disruption of the regulated mechanism resulting in metabolism disorders and impaired functions of sertoli cells [39].…”

Section: Discussionmentioning

confidence: 99%

Bisphenol A Induces Apoptosis in Liver Cells through Induction of ROS

Kourouma

Quan

Duan

et al. 2015

Advances in Toxicology

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Oxidative stress mechanisms are involved in hepatotoxicity. The liver is reported to be affected by bisphenol A (BPA) in animals studies and has been also reported to possess hepatic toxicity. This study aimed to examine association between liver health status and the effects of BPA on the antioxidant defense systems and liver biomarkers. BPA (0, 2, 10, and 50 mg/kg) body weight was mixed in corn oil and intraperitoneally administered every forty-eight hours for 30 days in dose-dependent manner. There was no significant difference between the body weight and weight of rat liver in BPA-treated groups and control groups. The study results show that the levels of malondialdehyde (MDA) and hydrogen peroxide (H 2 O 2 ) increased after exposure to BPA. However, the antioxidant enzymes catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-PX) were significantly ( < 0.001, < 0.05, and < 0.001, resp.) decreased at 50 mg/kg dosage. Liver markers activities such as lactate dehydrogenase (LDH), glutamic-oxalacetic transaminase (GOT), and glutamic-pyruvic transaminase (GPT) were significantly increased, while -glutamyl transferase ( -GT) activity was decreased. BPA exposure increased activity of liver biomarkers indicating liver hyperactivity. Analysis of the liver section provided essential evidence of liver apoptosis. Moreover, BPA may lead to induced toxic response of liver oxidative system.

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The effect of maternal exposure to endocrine disrupting chemicals on fetal and neonatal development: A review on the major concerns

Mallozzi¹,

Bordi²,

Garo³

et al. 2016

Birth Defects Research Pt C

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There is a widespread exposure of general population, including pregnant women and developing fetuses, to the endocrine disrupting chemicals (EDCs). These chemicals have been reported to be present in urine, blood serum, breast milk, and amniotic fluid. Endocrine disruptions induced by environmental toxicants have placed a heavy burden on society, since environmental exposures during critical periods of development can permanently reprogram normal physiological responses, thereby increasing susceptibility to disease later in life-a process known as developmental reprogramming. During development, organogenesis and tissue differentiation occur through a continuous series of tightly-regulated and precisely-timed molecular, biochemical, and cellular events. Humans may encounter EDCs daily and during all stages of life, from conception and fetal development through adulthood and senescence. Nevertheless, prenatal and early postnatal windows are the most critical for proper development, due to rapid changes in system growth. Although there are still gaps in our knowledge, currently available data support the urgent need for health and environmental policies aimed at protecting the public and, in particular, the developing fetus and women of reproductive age. Birth Defects Research (Part C) 108:224-242, 2016. © 2016 Wiley Periodicals, Inc.

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Prenatal bisphenol A and birth outcomes: MOCEH (Mothers and Children's Environmental Health) study

Cited by 120 publications

References 49 publications

Maternal Urinary Bisphenol A Concentration During Midterm Pregnancy and Children’s Blood Pressure at Age 4

Maternal Urinary Bisphenol A Concentration During Midterm Pregnancy and Children’s Blood Pressure at Age 4

Bisphenol A Induces Apoptosis in Liver Cells through Induction of ROS

The effect of maternal exposure to endocrine disrupting chemicals on fetal and neonatal development: A review on the major concerns

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