Maternal Urinary Bisphenol A Concentration During Midterm Pregnancy and Children’s Blood Pressure at Age 4

Bae, Sanghyuk; Lim, Youn Hee; Lee, Young Ah; Shin, Choong Ho; Oh, Se Young; Hong, Yun–Chul

doi:10.1161/hypertensionaha.116.08281

Cited by 48 publications

(38 citation statements)

References 40 publications

(39 reference statements)

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“…Potential covariates for inclusion in the statistical models were selected a priori, following a literature review [ 12 , 13 , 41 ]. Prenatal information was obtained using questionnaires at the time of recruitment; variables of interest included maternal age (years), gestational age (weeks), smoking (yes or no), drinking alcohol during pregnancy (yes or no), educational attainment (≤ or > than high school), parity (first vs. second or later child), and CES-D scores (0–60 points).…”

Section: Methodsmentioning

confidence: 99%

“…Generalized additive models (GAMs) were constructed to investigate the relationship between prenatal and postnatal BPA concentrations and social impairments at age 4. BPA has non-monotonic effects [ 41 , 43 ]; therefore, we constructed 2 models, including 1 with a linear BPA term and another spline model for BPA exposure (4 degrees of freedom). When the shape of the association in GAMs looked nonlinear, we compared the AIC of linear and spline models to select a better-fit model for a given set of data.…”

Section: Methodsmentioning

confidence: 99%

“…Second, we estimated prenatal and postnatal BPA effects at concentrations that were either less than, or equal to/greater than, threshold BPA concentrations, using piecewise linear regression models and the threshpt function in the HEAT package [ 44 ] of R software (R Development Core Team, https://cran.r-project.org/ ). Piecewise linear regression analysis has been used to determine flexion points in non-linear relationships [ 41 , 45 , 46 ] using AIC as a measure of the relative quality of a statistical model for a given set of data. We modeled scores on the K-SCQ as a Poisson distribution and estimated the effects of BPA on the total and subcategory scores for social impairments (social interaction, social communication, and behavior patterns).…”

Section: Methodsmentioning

confidence: 99%

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Prenatal and postnatal bisphenol A exposure and social impairment in 4-year-old children

et al. 2017

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BackgroundPrenatal and postnatal exposure to bisphenol A (BPA) may affect early brain development. Rodent studies suggest that prenatal and postnatal neurodevelopmental toxicity from BPA exposure may manifest as social deficits in offspring. We investigated the association between prenatal and postnatal exposure to BPA and social impairments in a sample of 4-year-old children.MethodsWe recruited second-trimester pregnant women between 2008 and 2011, and measured their creatinine-adjusted prenatal urine BPA levels. In 2014-2015, a subset of 4-year-old children born to these women underwent neurobehavioral assessment and physical examination. We collected urine and blood from the children and assessed social impairments, including deficits in social interaction, social communication, and other behavior patterns using the Korean version of the Social Communication Questionnaire (K-SCQ) (n = 304). We examined social impairments associated with prenatal exposure at mid-term pregnancy and postnatal exposure to BPA at 4 years of age, using linear and piecewise linear regression models.ResultsThe relationship between prenatal BPA exposure and social communication was non-linear and statistically significant at or above the flexion point for BPA levels of 3.0 μg/g creatinine in girls (58.4%, 95% confidence interval [CI], 6.5% to 135.8%). Each 2-fold increase in postnatal BPA exposure was significantly associated with an 11.8% (95% CI, 0.6% to 24.3%) increase in impairment in social communication in 4-year old girls, as indicated by the linear regression model.ConclusionPrenatal and postnatal BPA exposure is associated with social impairment at 4 years of age, particularly in girls.Electronic supplementary materialThe online version of this article (doi:10.1186/s12940-017-0289-2) contains supplementary material, which is available to authorized users.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Prenatal and postnatal bisphenol A exposure and social impairment in 4-year-old children

et al. 2017

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“…It has to be noted that, although exposure levels of BPA as the ones estimated in Slovenia are considered safe (using the EFSA (t-TDI) as reference dose), several cohort studies have recently associated environmentally relevant BPA exposure levels with adverse health effects. Exposure to BPA above a certain threshold (4.5 μg/g creatinine in mother urine) during pregnancy has been associated with higher diastolic blood pressure of the children (Bae et al, 2017), while other studies have associated environmentally relevant exposure levels with autism spectrum disorders (Stein et al, 2015) and obesity (Oppeneer and Robien, 2015). It is expected that future cohort studies that properly account for differences in BED (and not only for differences in the biomonitored data), would provide more robust associations between BPA exposure levels and potential health effects.…”

Section: Discussionmentioning

confidence: 99%

Risk characterization of bisphenol-A in the Slovenian population starting from human biomonitoring data

Sarigiannis

Tratnik

Mazej

et al. 2019

Environmental Research

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The current study aims to characterize exposure and risk associated to bisphenol-A (BPA) exposure in Slovenia, starting from biomonitoring data. Based on the urinary data, daily intake for the individuals was back-calculated using a physiology based biokinetic (PBBK) model properly parameterized for BPA, coupled with an exposure reconstruction algorithm. Re-running the PBBK model in forward mode allowed the estimation of biologically effective dose (free plasma BPA) and the respective daily area under the curve (AUC). Finally, risk characterization ratio was derived using both external and internal dose metrics. The urinary BPA levels were found low, with GM of 0.79, 1.51 and 0.20 μg/g creatinine for mothers, children and fathers respectively, similar to the levels of other European countries. Based on the above and accounting for the dynamics of exposure and biokinetics, daily intake was estimated, median exposure levels have been estimated equal to 0.019, 0.035 and 0.005 μg/kg_bw/d for mothers, fathers and children respectively. The highest estimated intake level was found in a child, equal to 0.87 μg/kg_bw/d, while the maximum intake for mothers and fathers were 0.7 and 0.8 μg/ kg_bw/d respectively. The respective RCR levels using the EFSA t-TDI of 4 μg/kg_bw/d were 2 magnitudes of order lower below 1, independently of the selected method. It has to be noted that had daily intake been estimated solely based on the urinary concentrations mass balance, the estimated intake would be lower, as a result of the oversimplification on exposure and elimination time dynamics. This highlights the importance for using PBBK modelling based exposure reconstruction schemes for rapidly metabolized and excreted compounds such as BPA, as well as the study design of efficient sampling for rapidly metabolized compounds.

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“…BPA exposure during both childhood and adulthood has been linked to incidence of CVD. Children who experienced in utero exposure to elevated BPA levels possessed significantly higher diastolic blood pressure at age 4 [198]. In adults, the association of BPA with CVD was first reported during review of the 2003-2004 NHANES data, where in 1455 adults, the mean urinary BPA levels were higher in those diagnosed with coronary artery heart disease, angina, and myocardial infarction [199].…”

Section: Cardiovascular Diseasementioning

confidence: 99%

Perturbation of Nuclear Hormone Receptors by Endocrine Disrupting Chemicals: Mechanisms and Pathological Consequences of Exposure

Hall

Greco

2019

Cells

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Much of the early work on Nuclear Hormone Receptors (NHRs) focused on their essential roles as mediators of sex steroid hormone signaling in reproductive development and function, and thyroid hormone-dependent formation of the central nervous system. However, as NHRs display tissue-specific distributions and activities, it is not surprising that they are involved and vital in numerous aspects of human development and essential for homeostasis of all organ systems. Much attention has recently been focused on the role of NHRs in energy balance, metabolism, and lipid homeostasis. Dysregulation of NHR function has been implicated in numerous pathologies including cancers, metabolic obesity and syndrome, Type II diabetes mellitus, cardiovascular disease, hyperlipidemia, male and female infertility and other reproductive disorders. This review will discuss the dysregulation of NHR function by environmental endocrine disrupting chemicals (EDCs), and the associated pathological consequences of exposure in numerous tissues and organ systems, as revealed by experimental, clinical, and epidemiological studies.

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Maternal Urinary Bisphenol A Concentration During Midterm Pregnancy and Children’s Blood Pressure at Age 4

Cited by 48 publications

References 40 publications

Prenatal and postnatal bisphenol A exposure and social impairment in 4-year-old children

Prenatal and postnatal bisphenol A exposure and social impairment in 4-year-old children

Risk characterization of bisphenol-A in the Slovenian population starting from human biomonitoring data

Perturbation of Nuclear Hormone Receptors by Endocrine Disrupting Chemicals: Mechanisms and Pathological Consequences of Exposure

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