Prenatal Alcohol Exposure Affects Frontal–Striatal BOLD Response During Inhibitory Control

Fryer, Susanna L.; Tapert, Susan F.; Mattson, Sarah N.; Paulus, Martin P.; Spadoni, Andrea D.; Riley, Edward P.

doi:10.1111/j.1530-0277.2007.00443.x

Cited by 143 publications

(177 citation statements)

References 61 publications

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“…Specifically, caregivers viewed adolescents as having significantly more difficulty with their ability to control their emotions and behavior in social situations, participation and relations to their family, competence and accomplishments, competence in classroom tasks, and their ability to give and receive affect. These difficulties may be related to deficits in inhibitory control commonly found among adolescents with PAE (Fryer et al, 2007). One possible explanation for the high level of reported problems by caregivers in the present study could be due to the fact that living and caring for an adolescent with PAE is a demanding and stressful job (Giunta & Streissguth, 1988;Paley et al, 2005;2006) and therefore parental stress may have exacerbated some of the scores on these measures.…”

Section: Discussionmentioning

confidence: 43%

Adaptive Functioning, Social Skills, Mental Health, and Personal Strengths among Adolescents with Prenatal Alcohol Exposure (PAE)

Mariasine¹,

Pei²,

Poth³

et al. 2014

IJPS

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Three key areas of dysfunction reported as having a significant impact on how adolescents with Prenatal Alcohol Exposure (PAE) navigate their teen years and work towards independence are: mental health, social skills, and adaptive functioning. However, little is known about how adolescents with PAE perceive their own functioning relative to others, and what they and others see as potential strengths on which they may build. Participants included 32 adolescents (17 male, 15 female); 31% had confirmed prenatal exposure to alcohol (PAE) and the remaining 69% had a diagnosis of a Fetal Alcohol Spectrum Disorder (FASD). Adolescents and their caregivers completed the following measures: ABAS-2 (adaptive skills), SSIS (social skills), BASC-2 (mental health functioning), and BERS-2 (personal strengths). Overall, caregivers rated adolescents as having significantly more difficulties across all measures assessed when compared to the adolescents. The only area of agreement between caregiver and adolescents prenatally exposed to alcohol was on career strength. The knowledge gained from the results of this exploratory study can help adolescents with PAE better understand themselves and help researchers to better characterize this population.

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Section: Discussionmentioning

confidence: 43%

Adaptive Functioning, Social Skills, Mental Health, and Personal Strengths among Adolescents with Prenatal Alcohol Exposure (PAE)

Mariasine¹,

Pei²,

Poth³

et al. 2014

IJPS

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“…Children with prenatal tobacco [117] or marijuana [118] exposure were more likely to commit commission errors while performing the go/no-go task, but children with prenatal alcohol or cocaine exposure showed no behavioral differences in task performance. Prenatal alcohol exposure was associated with increased brain activation in prefrontal regions and less activation in the caudate compared to controls [119]. A similar pattern is demonstrated in adolescents with prenatal alcohol exposure suggesting long-term changes in brain function associated with response inhibition [120].…”

Section: Inhibitory Controlsupporting

confidence: 55%

Review of Current Neuroimaging Studies of the Effects of Prenatal Drug Exposure: Brain Structure and Function

Willford¹,

Smith²,

Kuhn³

et al. 2016

Recent Advances in Drug Addiction Research and Clinical Applications

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Neuroimaging tools have provided novel methods for understanding the impact of prenatal drug exposure on brain structure and function and its relation to development and behavior. Information gained from neuroimaging studies allows for the investigation of how prenatal drug exposure alters the typical developmental trajectory. The current prevalence and characteristics of prenatal drug exposure and its implications for vulnerable periods of brain development are reviewed. Structural and functional neuroimaging methods are introduced with examples of how study results from prenatal alcohol, cocaine, marijuana, and tobacco exposure further our understanding of the neurodevelopment impact of prenatal drug exposure. Prenatal drug neuroimaging studies have advanced our understanding of mechanisms and functional deficits associated with prenatal drug exposure. Studies have identified brain circuits associated with the default mode network, inhibitory control, and working memory that show differences in function as a result of prenatal drug exposure. The information gained from studies of prenatal drug exposure on brain structure and function can be used to make connections between animal models and human studies of prenatal drug exposure, identify biomarkers of documented effects of prenatal drug exposure on behavior, and inform prevention and intervention programs for young children.

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“…Notably, a similar association in children with FASDs was recently obtained, and interpreted as signaling the need for extra effort allocation to mitigate decreased frontostriatal efficiency. 33 One may argue that in both our tasks successful performance was dependent on motivation and effort allocation requiring intact frontolimbic circuits including the thalamus. Thalamic activation plays a key role in preserving task performance by modulating arousal in proportion to task demands.…”

Section: Discussionmentioning

confidence: 97%

Differentiating attention deficits in children with fetal alcohol spectrum disorder or attention‐deficit–hyperactivity disorder

Kooistra

Crawford

Gibbard

et al. 2010

Develop Med Child Neuro

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CPT Continuous Performance Task FASD Fetal alcohol spectrum disorder AIM The attention and inhibition problems found in children with attention-deficit-hyperactivity disorder (ADHD) are also common in children with fetal alcohol spectrum disorders (FASDs). Attempts to distinguish ADHD from FASDs in terms of these deficits are rare and were pursued in this study.METHOD A total of 116 children (47 with ADHD, 31 males, 16 females; 30 with FASDs, 17 males, 13 females; and 39 comparison children, 20 males, 19 females) participated. The mean age was 9 years 4 months (SD 1y 8mo) in the ADHD groups, 8 years 10 months (SD 1y 2mo) in the FASD group, and 9 years 1 month (SD 1y 1mo) in the comparison group. Sustained attention was tested with a slow event rate continuous performance task (CPT). Inhibitory control was tested with both a slow and fast event rate Go ⁄ No-Go task. RESULTSOn the CPT task, children with ADHD, combined type (ADHD-C), ADHD, primarily inattentive type (ADHD-PI), and FASDs showed greater declines in task performance as a function of time than comparison children, suggesting sustained attention problems in all clinical groups. Children's Go ⁄ No-Go performance was event-rate dependent, with the ADHD-C group being affected in the slow condition and the ADHD-PI and FASD groups having problems with the fast condition.INTERPRETATION Children with ADHD-C are typically impaired in handling understimulation, while children with FASDs may have problems with overstimulation. The dissociation in responsivity to event rate between groups may have significant differential diagnostic value.The modern fetal alcohol spectrum disorders (FASDs) concept dates back to 1973, when it was first described as fetal alcohol syndrome (FAS).1 Since then, numerous papers have reported on the neurobehavioural symptoms associated with the disorders, including attention problems, restlessness, and impulsivity.2 Such problems are typically also seen in children with attention-deficit-hyperactivity disorder (ADHD).The fact that attention and impulsivity problems characterize both FASDs and ADHD has fuelled speculation regarding their overlap, but this possibility has rarely been tested by directly comparing both groups in the same design using neurocognitive tests of attention. Nanson and Hiscock 3 compared children with FAS with children with ADHD and a comparison group on a series of attention tasks. While the children with FAS were slower than those in the other two groups, their impulsivity and attention problems were similar to those of the children with ADHD. In addition, Coles et al. 4 directly compared the attention profiles of children with FAS and children with ADHD. Children with FAS had difficulties with encoding and shifting attention, while the children with ADHD had problems with focusing and sustaining attention. Interestingly, children with ADHD were found to be impulsive, unlike the children with FAS.The clinical relevance of the attention and impulsivity problems in ADHD is undisputed. In the search for the etiolog...

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Prenatal Alcohol Exposure Affects Frontal–Striatal BOLD Response During Inhibitory Control

Abstract: These data provide an account of response inhibition-related brain functioning in youth with FASD. Furthermore, results suggest that the frontal-striatal circuitry thought to mediate inhibitory control is sensitive to alcohol teratogenesis.

Cited by 143 publications

References 61 publications

Adaptive Functioning, Social Skills, Mental Health, and Personal Strengths among Adolescents with Prenatal Alcohol Exposure (PAE)

Adaptive Functioning, Social Skills, Mental Health, and Personal Strengths among Adolescents with Prenatal Alcohol Exposure (PAE)

Review of Current Neuroimaging Studies of the Effects of Prenatal Drug Exposure: Brain Structure and Function

Differentiating attention deficits in children with fetal alcohol spectrum disorder or attention‐deficit–hyperactivity disorder

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