Premières applications neurophysiologiques d'une méthode permettant le blocage électif et réversible de structures centrales par réfrigération localisée

Dondey, M; Albé-Fessard, D; Beau, J Le

doi:10.1016/0013-4694(62)90092-5

Cited by 30 publications

(6 citation statements)

References 1 publication

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“…Cryotips are popular for cooling deep brain structures, where the site of cooling is desired to be as localized as possible. Cryotips are concentric tubes through which a coolant is passed down the inside shaft to localize the cooling to the tip of the shaft (Dondey et al, 1962). Additional heating elements have also been added to the outside shaft to prevent the unintentional inactivation of other, more superficial structures (Skinner and Lindsley, 1968;Zhang et al 1986;Campeau and Davis, 1990).…”

Section: Introductionmentioning

confidence: 99%

The cryoloop: an adaptable reversible cooling deactivation method for behavioral or electrophysiological assessment of neural function

Lomber

Payne

Horel

1999

Journal of Neuroscience Methods

211

233

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We describe a very adaptable reversible inactivation technique for the behavioral or electrophysiological analysis of neural circuits. The cryoloop device can be permanently implanted or topically applied in an acute preparation to apply cold to discrete surface regions of the central nervous system (e.g. cerebral cortex or midbrain). The cryoloop consists of a custom shaped, stainless steel, hypodermic tubing and cooling is effected by passing chilled methanol through the lumen of the tubing. Cryoloop temperature is monitored by a microthermocouple attached to the union of the loop, and can be maintained within 9 1°C of a desired temperature. In chronic preparations, implanted cryoloops have been maintained in cats and monkeys for periods in excess of 2 years. After this period there are no structural, metabolic of functional changes in the deactivated tissue, and full reversibility of cooling-induced effects is maintained. Operation of multiple cryoprobes provides great flexibility of experimental protocols, permits double and triple functional dissociations to be made, and strengthens experimental design considerably.

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Section: Introductionmentioning

confidence: 99%

The cryoloop: an adaptable reversible cooling deactivation method for behavioral or electrophysiological assessment of neural function

Lomber

Payne

Horel

1999

Journal of Neuroscience Methods

211

233

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“…used for cooling the right hemisphere. In later experiments a needle cooled by the expansion of propane [Dondey et al, 1962] was used with a shaped metal foot. In both cases cooling below 100 C. but not below 00 C. was effective in producing temporary nerve cell paralysis.…”

Section: Methodsmentioning

confidence: 99%

The Function of the Callosal Connections of the Visual Cortex

1965

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There is anatomical evidence in cats and baboons of cells at the margin of area 17 which have callosal connections to corresponding points in the opposite hemisphere.The function of such a pathway has been studied in cats after one optic tract has been cut. The corresponding hemisphere now gives early visual responses only at the margin of area 17. Such responses can only be elicited by light stimuli near the vertical meridian of the visual field. These responses are abolished by cooling the corresponding points in the opposite hemisphere and by cutting the corpus callosum.This pathway appears to provide some functional union for the two halves of the visual field.

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“…The surface of the cerebral cortex can be cooled by the implantation or application of cooling chambers or probes, the temperature being monitored by built-in thermistors or thermocouples (Dondey et al 1960;Bindman et al 1963;Gartside and Lippold 1 967 ; Gorman and Silfvenius 1 967 ; Pasztor and Kukorelli 1967;Shacter and Schuck~nan 1967;Wallcr and Feldrnan L467). Deep-lying brain areas may be cooled by probes directed by a stereotaxic instrument to study the effect of local arrest of function upon behavior or upon the conduction of nerve impulses (Mark et a?. 2 961 ; Dondey et al 1962;Skinner andLindsley 1967, 1968).…”

mentioning

confidence: 99%

The effect of local cooling upon spontaneous and evoked electrical activity of cerebral cortex

Jasper¹,

Shacter²,

Montplaisir³

1970

Can. J. Physiol. Pharmacol.

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1970. The effect of local cooling upon spontaneous and evoked electrical activity of cerebral cortex. Can. J. Physiol. Pharrnacol. 48, 640-652.The effect of local cooling sf the surface of the cerebral cortex by means of a metal chamber implanted in the skull was studied while recording evoked and spontaneous electrical activity from the center of a cooled area of 1 cm2. Direct cortical responses to local stirnulatioir of the cortical surface decreased rapidly and progressively to dissppear at starface ternpcratures of 20-22 "C. Onset and peak latencies were prolonged with a Qlo of 1.4 and 1.7 respectively.Response duration was prolonged with decreasing an-nplitude, having a Q,, of about 2.6. Surface cooling to 8-12 "C was necessary to abolish all postsynaptic components of sorn;ltic and auditory evoked potentials, recruiting responses, and spontaneous barbiturate spindles. Latencies of these responses were also increased with a el,, of 1 .?-1.4 while the Qlo for arnplitude was consistently higher (2.8-2.4). Allowing for a gradient of increasing temperature from stirface to depth it is concluded that all synaptic processes are blockcd at tennperatrares of 20-22 "C. Synaptic mechanisms determining latency were csnsistenaly different from those afetern-mining amplitude as judged by consistent diflerences in the Qlo sf latency and amplitude for all postsynaptic responses studied in these experiments.

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Premières applications neurophysiologiques d'une méthode permettant le blocage électif et réversible de structures centrales par réfrigération localisée

Cited by 30 publications

References 1 publication

The cryoloop: an adaptable reversible cooling deactivation method for behavioral or electrophysiological assessment of neural function

The cryoloop: an adaptable reversible cooling deactivation method for behavioral or electrophysiological assessment of neural function

The Function of the Callosal Connections of the Visual Cortex

The effect of local cooling upon spontaneous and evoked electrical activity of cerebral cortex

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