Premier cas d’Enterococcus faecalis résistant à la vancomycine en Algérie

Aggoune, Nadjet; Chabani, A.; Tiouit, D.; Naim, M.; Rahal, K

doi:10.1016/j.medmal.2008.05.003

Cited by 5 publications

(3 citation statements)

References 7 publications

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“…As in Batna, very few reports have described VRE in other Algerian ( http://www.sante.dz/aarn/alerte.htm ) or North Africa hospitals. 12 , 14 , 40 , 41 In Algeria, the first VRE identified in Algiers University Hospital was an E. faecalis isolate from a urine sample in 2006. 12 More recently, single-center and multicenter epidemiological studies conducted on Enterococcus spp.…”

Section: Discussionmentioning

confidence: 99%

“… 12 , 14 , 40 , 41 In Algeria, the first VRE identified in Algiers University Hospital was an E. faecalis isolate from a urine sample in 2006. 12 More recently, single-center and multicenter epidemiological studies conducted on Enterococcus spp. isolated from human infections in three other cities located in north-eastern Algeria between 2010 and 2013 did not find any VRE while a study on MDR bacteria isolated from patients hospitalized in the Intensive Care Unit of the University Hospital of Constantine, the main regional hospital of North-East Algeria, between 2011 and 2015, found 10 VREfm, with no VRE identified during the first 2 years, and two, six, and two VREfm identified in 2013, 2014, and 2015, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…In Algeria, sporadic cases are notified across the country since the first report of a VREfm in 2006. 12 However, only few studies identified the genetic support for vancomycin resistance in VRE 13 and there is no previously published molecular epidemiology study of VRE. 14 Here, we report the clinical and bacteriological characteristics of the first cases of HAIs involving VRE in the Batna University Hospital (North-East Algeria) identified during a 6-month period.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

First molecular characterization of related cases of healthcare-associated infections involving multidrug-resistant <em>Enterococcus faecium vanA</em> in Algeria

Benammar¹,

Pantel²,

Aujoulat³

et al. 2018

IDR

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PurposeVancomycin-resistant Enterococcus (VRE) faecium (VREfm) are highly resistant bacteria emerging worldwide and rarely studied using molecular tools in Algeria since their first report in 2006. The aim of the study was to investigate healthcare-associated infections (HAIs) involving the first VRE in Batna University Hospital, Algeria, and characterize isolates using molecular tools.Patients and methodsMedical charts were reviewed for patients with VREfm. van genes were detected by multiplex polymerase chain reaction (PCR), and strains were characterized by automated repetitive sequence-based PCR (rep-PCR), multiplex rep-PCR, pulsed-field gel electrophoresis (PFGE), and multilocus sequence typing (MLST).ResultsDuring a 6-month period, VREfm infections occurred in four patients hospitalized in three wards. The four isolates were E. faecium vanA belonging to the hospital-adapted clonal complex 17. PCR-based methods did not discriminate the isolates but MLST and PFGE delineated a subgroup of three VREfm of identical pulsotype and sequence type (ST) 80 (yet identified for five isolates in the international PubMLST database) while the fourth isolate was of ST789 (not previously identified for a VREfm) and displayed an unrelated pulsotype. The three genotypically related isolates were recovered in patients who underwent surgery in the same department, suggesting an outbreak for which the source and route of transmission remained unidentified.ConclusionThis first molecular epidemiology study of VRE in Algeria was useful in delimiting an outbreak involving three of the four HAI cases and revealed rarely encountered genotypes. Considering the threat and burden of VRE infections worldwide, particularly in the USA, and the late emergence in Algeria, our study supports the urgent need for improved and early adequate infection control measures to avoid VRE spread in North African hospitals.

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