Premenstrual asthma and leukotriene variations in the menstrual cycle

Vega, A. Vega; Sánchez-Ramos, José Luis; Pérez, José Antonio Maldonado; Oliva, Rosa Vázquez; Nieto, Jorge M.; Rico, Ignacio Vázquez; García, J M Ignacio; Palacios, Pedro Romero; Olbah, M. Alwakil; Gallardo, J.F. Medina

doi:10.1016/j.aller.2011.09.007

Cited by 5 publications

(6 citation statements)

References 27 publications

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“…Leukotriene receptor antagonists exert a combined anti-inflammatory and bronchodilating effect [ 14 ] and are considered an adjuvant therapy for asthma exacerbations, according to a GINA statement [ 2 ]. Women with PMA exhibit significantly higher levels of serum leukotrienes in the premenstrual phase than in preovulatory, while no differences in serum leukotriene concentrations occur in asthmatic women without PMA [ 15 ].…”

Section: Perspective Strategies In Perimenstrual Asthma Treatmentmentioning

confidence: 99%

“…Pasaoglu et al obtained similar results in women with mild PMA who received montelukast, observing the absence of this beneficial effect in asthmatic women without PMA [ 221 ]. Conversely, Pereira-Vega et al analyzed serum leukotriene variations in women with and without moderate PMA, finding no differences in leukotriene levels between the preovulatory and premenstrual phases in these groups, and, therefore, not supporting an involvement of leukotrienes in the pathogenesis of moderate perimenstrual asthma [ 14 ].…”

Section: Perspective Strategies In Perimenstrual Asthma Treatmentmentioning

confidence: 99%

“…PMA occurs in up to nearly 40% of asthmatic women of reproductive age [ 7 ]. The beneficial effects of hormonal treatments, as well as leukotriene receptor antagonists and microbial-directed treatment strategies, have been proposed [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ]. Data on PMA in adolescents are limited, and its management is not fully established.…”

Section: Introductionmentioning

confidence: 99%

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Perimenstrual Asthma in Adolescents: A Shared Condition in Pediatric and Gynecological Endocrinology

et al. 2022

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Asthma is a frequent medical condition in adolescence. The worsening of the most common symptoms perimenstrually is defined as perimenstrual asthma (PMA). The cause of PMA remains unclear, but a role for hormonal milieu is plausible. Data on PMA in adolescents are limited, and its management is not fully established. We aimed to discuss the PMA phenomenon in young females from pathophysiology to preventive strategies, focusing on the relationship with the hormonal pattern. The fluctuation of estrogens at ovulation and before menstruation and the progesterone secretion during the luteal phase and its subsequent withdrawal seem to be the culprits, because the deterioration of asthma is cyclical during the luteal phase and/or during the first days of the menstrual cycle. Conventional asthma therapies are not always effective for PMA. Preventive strategies may include innovative hormonal contraception. Even a possible beneficial effect of other hormonal treatments, including estrogens, progestogens, and androgens, as well as leukotriene receptor antagonists and explorative approach using microbial-directed therapy, is considered. The underlying mechanisms, through which sex-hormone fluctuations influence asthma symptoms, represent a challenge in the clinical management of such a distressing condition. Further studies focused on young females are mandatory to promote adolescent health.

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Section: Perspective Strategies In Perimenstrual Asthma Treatmentmentioning

confidence: 99%

Section: Perspective Strategies In Perimenstrual Asthma Treatmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Perimenstrual Asthma in Adolescents: A Shared Condition in Pediatric and Gynecological Endocrinology

et al. 2022

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“…According to GINA (Global Initiative for Asthma) guidelines, contraceptive pills and/or leukotriene receptors, antagonists may be useful (evidence D) in the prevention and treatment of PMA [ 75 , 85 ]. Currently, additional hormonal therapies such as estrogens, progestogens, gonadotropin-releasing hormone (GnRH) analogues and androgens are taken into consideration [ 5 , 86 , 87 , 88 , 89 ].…”

Section: Introductionmentioning

confidence: 99%

An Overview on the Primary Factors That Contribute to Non-Allergic Asthma in Children

Klain

Dinardo

Salvatori

et al. 2022

JCM

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The prevalence of non-allergic asthma in childhood is low, peaking in late adulthood. It is triggered by factors other than allergens, like cold and dry air, respiratory infections, hormonal changes, smoke and air pollution. In the literature, there are few studies that describe non-allergic asthma in pediatric age. Even though it is a less common disorder in kids, it is crucial to identify the causes in order to keep asthma under control, particularly in patients not responding to conventional treatments. In this review, we discuss non-IgE-mediated forms of asthma, collecting the latest research on etiopathogenesis and treatment.

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“…Up to 40% of asthmatic women of childbearing age have PMA [7]. Hormonal therapies, leukotriene receptor antagonists, and microbially-targeted therapies have all been recommended as potential remedies for the condition [8][9][10][11][12][13][14][15][16][17]. Adolescent PMA is poorly understood, and there is no clear protocol for treating the condition.…”

Section: …………………………………………………………………………………………………… Introduction:-mentioning

confidence: 99%

Risk Factors and Prevalence of Catamenial Asthma (Perimenstrual Asthma, Pma): A Cross-Sectional Study

Sabban¹,

Abousada²,

Alotaibi³

et al. 2022

IJAR

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Objective: To determine the risk factors and prevalence of catamenial asthma among women globally. Methods:This research employed a cross-sectional study design to gather and analyze the relevant data that leads to its findings. Wang and Cheng describe a cross-sectional study as an observational study that analyzes data from a population at a single point in time. Cross-sectional studies are helpful when establishing preliminary evidence while planning for a more advanced study in the future. Cross-sectional research requires researchers to record information, but not manipulate variables, as the case in this research study. Results:Study included 437 female participants. They had their menarche at different ages. They had their first menstrual period between the age of 12-14 years (n= 187, 42.8%) and between the age of 10-12 years (n= 176, 40.3%). It is noticed from the table that half of study participants experience worsening of asthma symptoms during menstruation (n= 219, 51.1%). More than half of study participants take painkillers medications for menstrual pain (n= 266, 60.9%). The last premenstrual asthma experience was before more than 1 year among 247 participants (56.5%) while it was before less than 1 year among 190 participants (43.5%). Most of study participants encountered it 2 times (n= 142, 32.5%) or 3-4 times (n= 140, 32%). The most frequent approach was via doctors advice (n= 205, 46.9%) followed by using over the counter drugs (n= 176, 40.3%). On the other hand, 20 participants just let it pass without any management (4.6%) and 36 participants attended at the emergency department (8.2%). Conclusion: Study results showed that most participants had their menarche at the age of 12-14 years. and more than one third of them encounter symptoms of catamenial asthma. Most of participants depend on doctors advice regarding the management with some of them attend at the emergency department to relieve their symptoms. More than half of study participants dont know how to manage their symptoms and avoid risks related to exposure to catamenial asthma.

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Premenstrual asthma and leukotriene variations in the menstrual cycle

Cited by 5 publications

References 27 publications

Perimenstrual Asthma in Adolescents: A Shared Condition in Pediatric and Gynecological Endocrinology

Perimenstrual Asthma in Adolescents: A Shared Condition in Pediatric and Gynecological Endocrinology

An Overview on the Primary Factors That Contribute to Non-Allergic Asthma in Children

Risk Factors and Prevalence of Catamenial Asthma (Perimenstrual Asthma, Pma): A Cross-Sectional Study

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