An Overview on the Primary Factors That Contribute to Non-Allergic Asthma in Children

Klain, Angela; Dinardo, Giulio; Salvatori, Alessandra; Indolfi, Cristiana; Contieri, Marcella; Brindisi, Giulia; Decimo, Fabio; Zicari, Anna Maria; Giudice, Michele Miraglia Del

doi:10.3390/jcm11216567

Cited by 6 publications

(3 citation statements)

References 111 publications

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“…2,3 Allergic asthma, driven by type 2 inflammation, is the most common form during childhood, followed by non-allergic asthma, where the symptoms may be triggered by viral infections and/or exercise. 4,5 Rhinoviruses are the most frequent trigger of wheeze among children over 1 year of age and have been associated with an increased risk of developing asthma at school-age. [6][7][8] It has been suggested that the combined effect of rhinovirus-induced wheeze and allergic sensitisation play a greater role than either of these factors on their own.…”

Section: Introductionmentioning

confidence: 99%

“…Factors that have been associated with this development are allergic sensitisation, asthma in first‐grade relatives and severe and frequent wheezing episodes 2,3 . Allergic asthma, driven by type 2 inflammation, is the most common form during childhood, followed by non‐allergic asthma, where the symptoms may be triggered by viral infections and/or exercise 4,5 …”

Section: Introductionmentioning

confidence: 99%

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Rhinovirus‐induced wheeze was associated with asthma development in predisposed children

Holmdahl,

Lüning,

Gerdin

et al. 2024

Acta Paediatrica

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AimThis study explored whether early‐life factors, such as rhinovirus‐induced wheeze and allergic sensitisation, were related to asthma at 11 years of age.MethodsWe focused on 107 children aged 6–48 months, who attended the paediatric emergency department at Astrid Lindgren's Children's Hospital in Stockholm, Sweden, with acute wheeze in 2008–2012. They also attended follow‐up visits at 11 years of age and were compared with 46 age‐matched healthy controls. Odds ratios (OR) with 95% confidence intervals (CI) were calculated with logistic regression.ResultsWe found that 62.6% of the acute wheeze cases had asthma at 11 years of age. Rhinoviruses at inclusion were the only common airway viruses associated with an increased asthma risk (OR 2.4, 95% CI 1.02–5.6). Other increased risks were parental heredity for asthma and/or allergies (adjusted OR 3.4, 95% CI 1.1–9.9) and allergic sensitisation at 2 years of age (adjusted OR 3.0, 95% CI 1.02–8.7). The highest prevalence of asthma was when children had both rhinovirus‐induced wheeze at inclusion and allergic sensitisation at 7 years of age.ConclusionOur findings highlight the importance of hereditary factors and allergic sensitisation on the development of asthma and suggest that rhinoviruses are associated with asthma development in predisposed children.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Rhinovirus‐induced wheeze was associated with asthma development in predisposed children

Holmdahl,

Lüning,

Gerdin

et al. 2024

Acta Paediatrica

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“…The rising worldwide incidences of asthma represent a vital healthcare issue for children [ 1 , 2 , 3 ], and its associated clinical symptoms may worsen life quality [ 4 ] and bring an economic burden [ 5 , 6 ]. Mounting pieces of evidence of various factors, including pathogenic bacteria colonization in the airway during the early life of children [ 7 ], exposure to smoke [ 8 , 9 ], O2 therapy [ 10 ], indoor allergen [ 11 , 12 ], air pollution [ 13 , 14 ], and climate change [ 15 , 16 ], have triggered the growing prevalence of asthma in children. Meanwhile, according to the hygiene hypothesis, improving hygienic environment standards and decreasing the chances of infections can subsequently increase the incidence of asthma in children [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

General Anesthesia in Early Childhood Significantly Reduces Asthma Incidence and Clinical Visits: A Nationwide Population-Based Cohort Study

Yang

Chang

et al. 2023

Children

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Few studies have focused on the consequence of exposure to general anesthesia (GA) in children’s early life with the risk of asthma and disease outcomes. The present study examines the correlation between exposure to GA under three years old and the subsequent course of asthma in a nationwide population-based cohort study. Our cases were acquired from Taiwan’s National Health Insurance Research Database (NHIRD). Children under three years old with either GA exposure or not during in-patient treatment from 1997 to 2008 were included. The study group was age- and sex-matched with a ratio of 1:2 to create the control group for comparison. The cohort included 2261 cases with GA and 4522 cases without GA as a control group. The incidence of asthma onset was significantly reduced in patients with GA exposure under 3 three years old (hazard ratio 0.64 (95% confidence interval 0.57~0.72), p < 0.001). In addition, regardless of whether the asthmatic clinical visits were before or after GA exposure, asthma onset patients before GA exposure have significantly fewer clinical visits than those without GA exposure (both p < 0.001, respectively). Using the Kaplan–Meier method, we also demonstrated that GA exposure was associated with favorable clinical visits in patients with asthma, whether their asthma was onset before GA (p = 0.0102) or after GA exposure (p = 0.0418) compared to non-GA-exposed controls. In the present study, we demonstrated that children with early GA exposure under three years old were at a reduced risk of developing asthma compared to the general population. Furthermore, we first reported that GA exposure significantly reduced clinical visits in patients with asthma regardless of whether their asthma onset was before or after GA exposure. It is indicated that GA exposure at a younger age could have potential clinical benefits for asthma than non-GA-exposed controls.

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Innovations in Asthma Care: Efficacy of Mobile App-Assisted Patient Education in Promoting Asthma Self-Management

Ghozali

2024

The Palgrave Encyclopedia of Disability

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An Overview on the Primary Factors That Contribute to Non-Allergic Asthma in Children

Cited by 6 publications

References 111 publications

Rhinovirus‐induced wheeze was associated with asthma development in predisposed children

Rhinovirus‐induced wheeze was associated with asthma development in predisposed children

General Anesthesia in Early Childhood Significantly Reduces Asthma Incidence and Clinical Visits: A Nationwide Population-Based Cohort Study

Innovations in Asthma Care: Efficacy of Mobile App-Assisted Patient Education in Promoting Asthma Self-Management

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