Premenopausal bleeding associated with hyperprolactinaemia

Ratchev, E.; Dokumov, S

doi:10.1016/0378-5122(94)00892-b

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…However, in a previous study, there was no significant correlation between age and PRL values in 54 patients with menstrual disorders, such as uterine bleeding. 12) Additionally, the dose of medication that was calculated based on the chlorpromazine dose was not significantly different in either group (with or without menstrual disorders), and the patients receiving risperidone had menstrual disorders. In a previous study, abnormal menstrual cycles were reported in 88% of women treated with risperidone compared with 48% of women taking first-generation antipsychotics.…”

Section: Discussionmentioning

confidence: 99%

Psychiatric Patients with Antipsychotic Drug-Induced Hyperprolactinemia and Menstruation Disorders

Takechi

Yoshioka

Kawazoe

et al. 2017

Biological & Pharmaceutical Bulletin

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Treatment with antipsychotic drugs has been associated with hyperprolactinemia. The same antipsychotic drugs have also been associated with side effects such as menstruation disorders. The aim of this study was to evaluate the prevalence of hyperprolactinemia and menstruation disorders in women undergoing antipsychotic treatment. We performed a retrospective chart review study of psychiatric patients who underwent laboratory testing for serum prolactin (PRL) level between March 2011 and March 2015 in Ehime University Hospital. Patients presenting with and without menstruation disorders were evaluated to determine if they presented concomitant hyperprolactinemia. Patients with menstrual disorders had a significant increase in serum PRL level with a mean of approximately 90 ng/mL. Those with menstrual disorders presented increased PRL levels by 2-fold that of patients without menstrual disorder. However, there was no significant difference in the equivalent dose of chlorpromazine between these two groups. Additionally, about 70% of patients with menstrual disorders received risperidone treatment. The receiver operating characteristic curve showed that the optimal cutoff point of serum PRL level associated with the development of menstrual disorders was 60 ng/mL. Based on these results, we concluded that patients with menstrual disorders presented increased serum PRL, and that most of them underwent treatment with risperidone.

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Section: Discussionmentioning

confidence: 99%

Psychiatric Patients with Antipsychotic Drug-Induced Hyperprolactinemia and Menstruation Disorders

Takechi

Yoshioka

Kawazoe

et al. 2017

Biological & Pharmaceutical Bulletin

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show abstract

“…In men, low sperm counts have been correlated with hyperprolactinemia (12) and in women hyperprolactinemia is frequently diagnosed in patients with infertility and men-strual cycle irregularities (13). Premenopausal anovulatory bleeding has also been associated with hyperprolactinemia (14). Osteopenia is an important clinical manifestation of hyperprolactinemia and has been attributed to deficiencies of the gonadal hormones (15).…”

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confidence: 99%