Prematurity and Related Biochemical Outcomes: Study of Bone Mineralization and Renal Function Parameters in Preterm Infants

Chauhan, Sarika Singh; Sarkar, Purnima Dey; Bhimte, Bhawna

doi:10.1155/2011/740370

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…Similarly no significant difference was noted in the result of serum calcium at 6th week also. However serum calcium was reported to be significantly lower in preterm neonates when compared to term controls, which is consistent with other study in this regard [25].…”

Section: Discussionsupporting

confidence: 92%

Osteopenia of prematurity: Assessment of Biochemical parameters in Very low birth weight preterm neonates

2016

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Background: Osteopenia of prematurity, commonly called as metabolic bone disease (MBD), is mostly described in preterm babies (< 36weeks) with very low birth weight (VLBW). This condition is characterized by a reduction in bone mineral content (osteopenia), with or without rachitic changes, and is caused by several nutritional and biomechanical factors. Objective: To determine the incidence of osteopenia of prematurity among high risk preterm VLBW babies and also to document changes in biochemical parameters including serum calcium, serum phosphate, serum alkaline phosphate (ALP) and serum creatinine in the above cases. Material and method: This prospective observational study includes all the very low birth weight babies born fromNovember 2012 to July 2014. Present study comprised of 60 VLBW neonates of which 10 were <28weeks, 32 were 28-31week and 18 were 31-34weeks of gestation. Estimations of biochemical parameters were done at 2 nd week of birth and again at 6 th week to detect the incidence of osteopenia. Result: There was a significant decrease inserum calcium and serum phosphorous level where asserum ALP documented a significant increase in preterm neonates when compared to control. 14 of 60 VLBW babies developed osteopenia of prematurity at 6 th week of life. Conclusion: As observed in the present study, gestational age, birth weight and ALP are considered to be significant risk factors and are associated with osteopenia. So early detection of this condition by monitoring of biochemical parameters in high-risk cases minimizes the development of osteopeniaand prevent future complications of osteopenia.

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Section: Discussionsupporting

confidence: 92%

Osteopenia of prematurity: Assessment of Biochemical parameters in Very low birth weight preterm neonates

2016

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“…(P value= 0.036) ( Table 5 ). In another study conducted by Chuhan, the risk of developing MBD was inversely related to GA and BW, while directly related to postnatal complications ( Chauhan et al, 2011 ). In our study, the frequency of rickets among the preterm infants was 37.9% (32 of a total of 58) and the frequency of osteopenia was 32.7% (19 of a total of 58), which is in analogy with other studies.…”

Section: Discussionmentioning

confidence: 99%

Comparing the Effects of Two Feeding Methods on Metabolic Bone Disease in Newborns with Very Low Birth Weights

Lotfi¹,

Arani²,

Amini³

et al. 2015

GJHS

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Introduction:Bone metabolic disease is an important issue in newborns with very low birth weight. The 80 percent of the transport of calcium (Ca) and phosphor (P) from mother to fetus takes place in the third trimester of pregnancy. This transport process is impaired with the preterm delivery of the newborn. On the other side, breast milk and formula are not competent resources to supply sufficient amounts of Ca and P to meet the requirements of the preterm newborn, thereby a greater reduction in the storage of these minerals. The current study has been done with the purpose of comparing the effects of two feeding methods on the indices of metabolic bone disease in newborns with very low birth weights (VLBW).Materials and Methods:The study design was cohort and the study was done on a total of 58 newborns with very low birth weights in Kashan Shahid Beheshti Hospital. The newborns were divided into two groups with 29 placed in the group of alternate feeding on preterm formula (preNan) and the other 29 placed in the group of breast milk and preterm formula (preNan). Eventually, the indices of bone metabolic disease were measured in both groups and were statistically analyzed.Results:The difference between the mean serum levels of Ca in different weeks and also between the two groups were significant (p=0.001). However, the changes in mean serum level of P in the two groups were not significant (P=0.151). The comparison of serum levels of alkaline phosphatase between the two groups indicated that their difference was significant and that they had been influenced by the feeding method (P=0.001). The serum level of bicarbonate, when compared between the two groups, was found to make a significant difference (P=0.001). The difference between the two feeding methods in precipitating rickets and osteopenia was not significant.Conclusion:According to the findings of current study, feeding on preterm formula (preNan) is associated with better and more desirable results, though the occurrence of rickets in the two groups had no significant difference.

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Prematurity and Related Biochemical Outcomes: Study of Bone Mineralization and Renal Function Parameters in Preterm Infants

Cited by 2 publications

References 15 publications

Osteopenia of prematurity: Assessment of Biochemical parameters in Very low birth weight preterm neonates

Osteopenia of prematurity: Assessment of Biochemical parameters in Very low birth weight preterm neonates

Comparing the Effects of Two Feeding Methods on Metabolic Bone Disease in Newborns with Very Low Birth Weights

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