Premature Ovarian Failure: Evidence for the Autoimmune Mechanism

Coulam, Carolyn B.; Kempers, Roger D.; Randall, Raymond V.

doi:10.1016/s0015-0282(16)45687-6

Cited by 100 publications

(30 citation statements)

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“…We cannot provide a definitive interpretation on the possible role of Ov-Ab in the pathogenesis of sterility. It can only be speculated that they could interfere with ovarian function since immunosuppressive treatment of patients with Ov-Ab and infertility has led to a normalization of menses (7,(14)(15)(16)(17). Experimental data are available on a complement-dependent cytotoxic effect on granulosa cells with a reduction of progesterone production when the serum from patients with Addison's disease, containing antibodies to corpus luteum, was added to granulosa cells in vitro (29).…”

Section: Discussion'mentioning

confidence: 99%

“…These ovarian antibodies (Ov-Ab) were considered to be part of an immune reaction involving steroid-producing cells. The purely morphological data arising from IFL have allowed recognition of different staining patterns, including Leydig cells, dispersed single cells in the ovarian interstitium, ovarian theca cells, corpus luteum, granulosa cells, and oocytes (1)(2)(3)7). In a follow-up study of patients with autoimmune polyglandular disease the appearance of Ov-Ab was found to be associated with a loss of ovarian function (6).…”

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confidence: 99%

“…Despite these first conceptual interpretations ofthe results, i.e., Ov-Ab being exclusively associated with polyendocrinopathies, a lack of relationship to either adrenal or pluriglandular insufficiency has also been observed (8)(9)(10)(11). Additional clinical settings where Ov-Ab can be observed are premature menopause, endometriosis, and systemic lupus erythematosus (7,10,12,13).…”

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confidence: 99%

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Ovarian failure and autoimmunity. Detection of autoantibodies directed against both the unoccupied luteinizing hormone/human chorionic gonadotropin receptor and the hormone-receptor complex of bovine corpus luteum.

Moncayo

Moncayo²,

Benz³

et al. 1989

J. Clin. Invest.

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We developed an ELISA system for the detection of human anti-ovarian antibodies. Bovine corpora lutea were extracted in PBS (pH 7.2) and fractionated by ultracentrifugation. Both the soluble fraction obtained after 80,000 g (S80) and the Tritonextracted membrane fraction (ST288) were used as antigens. Additionally, the luteinizing hormone (LH)/human chorionic gonadotropin (hCG) receptor was isolated by affinity chromatography (wheat germ agglutinin and LH-Sepharose) and also used as an antigen.In 7 of 14 patients with primary sterility and endometriosis a positive reaction was observed. Similarly, 6 of 16 patients with secondary sterility and endometriosis were also positive. Patients being stimulated for in vitro fertilization and presenting either primary or secondary sterility were positive in 5 of 22 and 6 of 16 cases, respectively. In the S80 test 41 of 60 sera presented IgG2 antibodies, whereas in the ST288 test 38 of 60 belonged to the IgG, subclass. Kappa and lambda chains were equally distributed.Some patients could recognize the unoccupied LH/hCG receptor as an antigen, while others recognized only the complex formed by the hormone plus the hormone receptor.The S80 and ST288 antigens were isolated by affinity chromatography. Gel permeation of the purified antigens revealed in each case the presence of an antigen complex. The apparent molecular weight was between 2,000 and 36,000 D. Cross-reactivity studies using affinity-purified antibodies demonstrated an antigenic relationship of the membrane, soluble, and extractable fractions. NAc-(beta-1 -4)-D-glucosaminide and -D-galactopyranoside were the main terminal glycosides.

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Section: Discussion'mentioning

confidence: 99%

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confidence: 99%

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Ovarian failure and autoimmunity. Detection of autoantibodies directed against both the unoccupied luteinizing hormone/human chorionic gonadotropin receptor and the hormone-receptor complex of bovine corpus luteum.

Moncayo

Moncayo²,

Benz³

et al. 1989

J. Clin. Invest.

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“…Oophoritis at biopsy was documented in 18/18 patients with POF and AAD (40,(87)(88)(89)(90)(91)(92)(93)(94)(95)(96). Autoimmune oophoritis is characterized by lymphocytic and plasma cell infiltration of the endocrine hilar cells, theca interna of growing follicles and corpora lutea.…”

Section: Pof Associated With Aadmentioning

confidence: 99%

Adrenal and ovarian autoimmunity

Betterle

Volpato²

1998

European Journal of Endocrinology

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“…1,3,12,15,21 Premature menopause is defined as ovarian failure after puberty and before the age of 40 years. 7 Affected women present with amenorrhea, infertility, and symptoms of hypoestrogenism. Biochemical assays reveal markedly elevated gonadotrophin levels.…”

Section: Discussionmentioning

confidence: 99%

Myasthenia gravis and premature ovarian failure

Ryan

Jones

2004

Muscle and Nerve

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We describe a patient who developed seropositive myasthenia gravis 16 years after she was diagnosed with autoimmune premature ovarian failure with antibodies to the receptor for follicle-stimulating hormone (FSH). Although thymectomy led to improvement of her myasthenic symptoms, menses did not resume. Such combined seropositivity for antibodies to acetylcholine and ovarian hormone receptors in a patient with myasthenia gravis and premature ovarian failure may reflect common disease mechanisms, although the precise pathogenesis of these disorders remains ill-defined.

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Premature Ovarian Failure: Evidence for the Autoimmune Mechanism

Cited by 100 publications

References 4 publications

Ovarian failure and autoimmunity. Detection of autoantibodies directed against both the unoccupied luteinizing hormone/human chorionic gonadotropin receptor and the hormone-receptor complex of bovine corpus luteum.

Ovarian failure and autoimmunity. Detection of autoantibodies directed against both the unoccupied luteinizing hormone/human chorionic gonadotropin receptor and the hormone-receptor complex of bovine corpus luteum.

Adrenal and ovarian autoimmunity

Myasthenia gravis and premature ovarian failure

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