Myasthenia gravis and premature ovarian failure

Ryan, Monique M.; Jones, H. Royden

doi:10.1002/mus.20067

Cited by 24 publications

(12 citation statements)

References 22 publications

(34 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antibodies to several potential ovarian antigens have been proposed as markers of ovarian autoimmunity. These include LH receptor [104], FSH receptor [105,106], zona pellucida [107] and other antigens [108], but the association of these antibodies with POI has not been confirmed in other studies [109][110][111].…”

Section: Ovarian Autoimmunity and Poimentioning

confidence: 86%

Primary ovarian insufficiency: X chromosome defects and autoimmunity

Persani¹,

Rossetti²,

Cacciatore³

et al. 2009

Journal of Autoimmunity

105

View full text Add to dashboard Cite

Section: Ovarian Autoimmunity and Poimentioning

confidence: 86%

Primary ovarian insufficiency: X chromosome defects and autoimmunity

Persani¹,

Rossetti²,

Cacciatore³

et al. 2009

Journal of Autoimmunity

105

View full text Add to dashboard Cite

“…[43][44][45][46] It seems likely that as with SC antibodies, multiple and shared antigens among endocrine organs raises susceptibility of involvement of multiple organs, including the ovary.…”

Section: Autoimmune Oophoritis As a Cause For Primary Ovarian Insuffimentioning

confidence: 99%

Ovarian autoimmune disease: clinical concepts and animal models

et al. 2014

View full text Add to dashboard Cite

The ovary is not an immunologically privileged organ, but a breakdown in tolerogenic mechanisms for ovary-specific antigens has disastrous consequences on fertility in women, and this is replicated in murine models of autoimmune disease. Isolated ovarian autoimmune disease is rare in women, likely due to the severity of the disease and the inability to transmit genetic information conferring the ovarian disease across generations. Nonetheless, autoimmune oophoritis is often observed in association with other autoimmune diseases, particularly autoimmune adrenal disease, and takes a toll on both society and individual health. Studies in mice have revealed at least two mechanisms that protect the ovary from autoimmune attack. These mechanisms include control of autoreactive T cells by thymus-derived regulatory T cells, as well as a role for the autoimmune regulator (AIRE), a transcriptional regulator that induces expression of tissue-restricted antigens in medullary thymic epithelial cells during development of T cells. Although the latter mechanism is incompletely defined, it is well established that failure of either results in autoimmune-mediated targeting and depletion of ovarian follicles. In this review, we will address the clinical features and consequences of autoimmune-mediated ovarian infertility in women, as well as the possible mechanisms of disease as revealed by animal models.

show abstract

“…MG is generally an isolated disorder but a minority of patients may develop MG in conjunction with other autoimmune organ failures such as autoimmune thyroid diseases, rheumatoid arthritis, pernicious anemia and systemic lupus erythematosus (2,3,4,5). Premature ovarian failure (POF) has been very rarely reported in association with MG. We report a case with MG in whom POF has resolved after thymectomy.…”

Section: Introductionmentioning

confidence: 99%

Resolution of Autoimmune Oophoritis after Thymectomy in a Myasthenia Gravis Patient

Çakır¹,

Özdemır²,

Eren³

et al. 2011

jcrpe

View full text Add to dashboard Cite

Myasthenia gravis (MG) is an autoimmune disorder characterized by autoantibodies against acetylcholine receptors. MG is generally an isolated disorder but may occur concomitantly with other autoimmune diseases. We describe an eighteen-year-old girl with MG who was admitted to our clinic with secondary amenorrhea and diagnosed as autoimmune oophoritis. Since her myasthenic symptoms did not resolve with anticholinesterase therapy, thymectomy was performed. After thymectomy, her menses have been regular without any hormonal replacement therapy. To our knowledge, this is the first report on a patient with autoimmune ovarian insufficiency and MG in whom premature ovarian insufficiency resolved after thymectomy, without hormonal therapy.Conflict of interest:None declared.

show abstract

Myasthenia gravis and premature ovarian failure

Cited by 24 publications

References 22 publications

Primary ovarian insufficiency: X chromosome defects and autoimmunity

Primary ovarian insufficiency: X chromosome defects and autoimmunity

Ovarian autoimmune disease: clinical concepts and animal models

Resolution of Autoimmune Oophoritis after Thymectomy in a Myasthenia Gravis Patient

Contact Info

Product

Resources

About