Premature ovarian failure 3 years after menarche in a 16-year-old girl following human papillomavirus vaccination

Abstract

SummaryPremature ovarian failure in a well adolescent is a rare event. Its occurrence raises important questions about causation, which may signal other systemic concerns. This patient presented with amenorrhoea after identifying a change from her regular cycle to irregular and scant periods following vaccinations against human papillomavirus. She declined the oral contraceptives initially prescribed for amenorrhoea. The diagnostic tasks were to determine the reason for her secondary amenorrhoea and then to investigate for possible causes of the premature ovarian failure identified. Although the cause is unknown in 90% of cases, the remaining chief identifiable causes of this condition were excluded. Premature ovarian failure was then notified as a possible adverse event following this vaccination. The young woman was counselled regarding preservation of bone density, reproductive implications and relevant follow-up. This event could hold potential implications for population health and prompts further inquiry. BACKGROUND

Human Papilloma Virus Vaccine and Primary Ovarian Failure: Another Facet of the Autoimmune/Inflammatory Syndrome Induced by Adjuvants

“…Herein, we have described three cases of POF following HPV vaccination. To the best of our knowledge, an additional case of POF in a 16‐year‐old young woman who was vaccinated with the quadrivalent HPV recombinant vaccine has already been reported by Little and Ward . In this case, as in our three cases, no other possible causes of POF were identified other than the HPV vaccine.…”

Autoimmune/Inflammatory Syndrome Induced by Adjuvants and Thyroid Autoimmunity

“…Little and Ward (22) also reported a case of POF succeeding HPV vaccination, in a 16-year-old patient, who presented irregular menses after taking the quadrivalent vaccine, followed by oligomenorrhea and amenorrhea. Her hormone profile also showed high levels of FSH and LH and low levels of estradiol and anti-mullerian hormone (AMH), and after excluding pregnancy and genetic, endocrinal, and other causes, she was diagnosed with POF.…”

How Silencing of Dissent in Science Impacts Woman. The Gardasil® Story

“…so the question is not whether Gardasil ® has the potential to cause serious AEs but the frequency with which this occurs, information that is not always revealed to parents. As of 2015 serious adverse events (AE's) following Gardasil ® vaccination that have been reported in the medical literature include: premature ovarian failure [78], Guillian Barre syndrome and lupus and a host of other autoimmune related diseases [79], erythema multiform and other dermatological disorders [80], nervous system disorders such as POTS and many others [34], including death [81]. Most of these events are dismissed by pharmaceutical company experts as coincidental, occurring no more often then they might have with a placebo.…”