Premature luteinization and in vitro fertilization outcome in gonadotropin/gonadotropin-releasing hormone antagonist cycles in women with polycystic ovary syndrome

Comparison of gonadotropin‐releasing hormone agonists and antagonists in assisted reproduction cycles of polycystic ovarian syndrome patients

“…GnRH antagonists inhibit premature LH rise, which could lead to premature luteinization, follicle maturation arrest and asynchrony of oocyte maturation. Although a recent study showed that patients with PCOS undergoing COH with exogenous GnRH antagonist in the presence of premature luteinization had a higher number of oocytes retrieved and mature oocytes, and similar clinical pregnancies to patients with PCOS without premature luteinization; 10 however, GnRH antagonists are associated with a reduction in the incidence of OHSS in PCOS patients.…”

Premature progesterone rise negatively correlated with live birth rate in IVF cycles with GnRH agonist: an analysis of 2,566 cycles

“…Several methods have been applied to studying the underlying mechanism of the occurrence of PPR. In some research, the authors just compared multiple variables between groups with or without PPR and the factors showing difference were regarded to be the reason of PPR (8,29,30). Such kind of comparison is somewhat simple and weak to distinguish causal from noncausal correlation, nor can it reflect the interaction among variables.…”

Gonadotropin-releasing hormone antagonist use in controlled ovarian stimulation and intrauterine insemination cycles in women with polycystic ovary syndrome

“…The possible explanation of why the patients could get pregnant despite premature luteinization may be nonreproducibility of the definition of premature luteinization for PCOS. In fact, recent research showed that patients with PCOS with premature luteinization had similar pregnancy rates to patients with PCOS without premature luteinization in IVF cycles (28).…”