Premalignant Fibroepithelial Tumors of Skin

Pinkus, Hermann

doi:10.1001/archderm.1953.01540060060009

Cited by 244 publications

(111 citation statements)

References 32 publications

(4 reference statements)

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“…Described by Pinkus 53 in 1953 the fibroepithelioma typically arises above the natal cleft or on the lower trunk as a pink or flesh colored nodule with a constricted inferior margin suggesting a seborrheic keratosis. 55 In this tumor, elongated basaloid epithelial strands manifesting slit-like retraction from stroma are enmeshed in a myxoid matrix or a background of proliferating spindle cells with abundant collagen (Figure 14).…”

Section: Fibroepithelioma Of Pinkusmentioning

confidence: 99%

“…These include, but are not restricted, to keratotic BCC, 39 infundibulocystic BCC (Figure 12), 42,43 follicular BCC, [44][45][46][47] which shows collision features with pilomatricoma, pleomorphic BCC ( Figure 13), 48,49 BCC with eccrine differentiation, [50][51][52] BCC with sebaceous differentiation, the fibroepithelioma of Pinkus (Figure 14), 53 and the BCC with myoepithelial differentiation. 54 Keratotic BCC Also known as pilar BCC as it appears to differentiate along pilosebaceous lines, the keratotic BCC manifests large basaloid tumor nests that are rounded and show central keratinization and degeneration.…”

Section: Introductionmentioning

confidence: 99%

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Basal cell carcinoma: biology, morphology and clinical implications

2006

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Basal cell carcinoma (BCC) is the most common malignant neoplasm of humans. Rising dramatically in incidence in North America, as likely reflects changing habits of the population and a move from more northerly climes to the sunbelt of the Southern and Southwestern United States, the incidence is surely to rise even higher in the future. The last decade has seen significant advances in our understanding of BCC biology and novel approaches to therapy, which hinge upon accurate diagnosis and subclassification by pathologists. The purpose of this review article is to summate the research advances in our understanding of BCC biology and to acquaint pathologists and clinicians to the practical issues in BCC diagnosis and subclassification which flow there from.

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Section: Fibroepithelioma Of Pinkusmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Basal cell carcinoma: biology, morphology and clinical implications

2006

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“…It mostly occurs in elderly persons, nearly all patients are older than 50 years of age (4,5,7,8,15,16). Some authors (5) reported a case occurring in a child, too.…”

Section: Resultsmentioning

confidence: 99%

“…Some authors (5) reported a case occurring in a child, too. Interval between the initial appearance of FEP and histological confi rmation of diagnosis is variable, it can range from a few months to several years (7,15). Some studies (4, 9) reported time of tumor growth 8-years that give evidence of its clinically favorable character.…”

Section: Resultsmentioning

confidence: 99%

“…Some studies (4, 9) reported time of tumor growth 8-years that give evidence of its clinically favorable character. The most common localization represents the lower trunk or extremities with a predilection for the lumbosacral regions (4,5,7,8,16). However, it has been also described in atypical areas, in which basalioma does not occur, for example penis (17).…”

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confidence: 99%

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Fibroepithelioma of Pinkus

Bartoš¹,

Pokorny²,

Zacharová³

et al. 2013

BLL

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Basal cell carcinoma (BCC) is recently the most common cancer in humans characterized by several histopathological subtypes. Fibroepithelioma of Pinkus (FEP) is traditionally classifi ed as a very rare variant of BCC, however, it manifests clinical and morphological differences that distinguish it from most other types BCCs. This study was performed to evaluate the incidence of FEP and clinical-pathological characteristics of patients diagnosed with this tumor. Four cases of primary FEP (3 females, 1 male, mean age 53.4 y) were analyzed retrospectively. The prevalence of FEP was 0.7 % of all diagnosed BCCs. Topographically, tumors were localized on the right brachium, right gluteal region, left mesogastrium, and right side of the abdomen. Histological examination showed typical anastomosing cords of basaloid cells extending from the overlying epidermis into the loose fi brous stroma in the dermis. Mitotic activity or signifi cant cellular atypia, as well as sign of solar dermatosis were absent. Mean horizontal and vertical diameter of the lesions were 7.7 and 2.8 mm, retrospectively. We did not observe infi ltration of deeper skin structures. All lesions were removed completely and classifi ed as pathological stage pT1. Three cases manifested typical picture of a "pure" FEP, one lesion had partially a feature of nodular type BCC, too. Although FEP is conventionally considered as indolent BCC variant with a favorable clinical outcome, recent evidences also favors its classifi cation as a form of trichoblastoma. This is appropriate example how some types of cutaneous tumors can overlap in terms of dignity and clinical-morphological characteristics. This should be taken into account in differential diagnosis and in predicting of biological behaviour of the individual tumors of the skin (Tab. 2, Fig. 3, Ref. 26). Full Text in PDF www.elis.sk.

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Basal cell carcinoma of skin metastatic to bone

Crammer¹

1970

Archives of Dermatology

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Premalignant Fibroepithelial Tumors of Skin

Cited by 244 publications

References 32 publications

Basal cell carcinoma: biology, morphology and clinical implications

Basal cell carcinoma: biology, morphology and clinical implications

Fibroepithelioma of Pinkus

Basal cell carcinoma of skin metastatic to bone

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