Preliminary Study on the Induction of Sperm Head Abnormalities in Mice, Mus musculus, Exposed to Radiofrequency Radiations from Global System for Mobile Communication Base Stations

Otitoloju, Adebayo A.; A., I.; Adewale, OA; Otubanjo, Olubunmi Adetoro; Osunkalu, Vincent Oluseye

doi:10.1007/s00128-009-9894-2

Cited by 55 publications

(34 citation statements)

References 14 publications

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“…Male mice exposed to RF-EMR from mobile phone base stations at a workplace complex and residential quarters had significantly and in dose-dependent manner more sperm head abnormalities (knobbed hook, pin-head and bananashaped sperm head) compared to unexposed animals (40% versus 2%, respectively) [7]. The study implicated that living in close proximity to mobile base stations might have an adverse outcome on male reproductive health [7].…”

Section: Studies In Malesmentioning

confidence: 90%

“…A number of recent reports have suggested a possible link between cell phone use and male infertility [4][5][6][7][8][9][10][11][12]. The concern has arisen that carrying a cellular phone near the reproductive organs such as the testes may cause dysfunction and particularly a decrease in sperm development and production, and thus decrease fertility in men.…”

Section: Studies In Malesmentioning

confidence: 99%

“…The study implicated that living in close proximity to mobile base stations might have an adverse outcome on male reproductive health [7]. Male albino Wistar rats (10-12 weeks old) were exposed to RF-EMR from an active mobile phone for 1 h continuously per day for 28 days [8].…”

Section: Studies In Malesmentioning

confidence: 99%

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Challenging cell phone impact on reproduction: A Review

Merhi

2012

J Assist Reprod Genet

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Purpose The radiofrequency electromagnetic radiation (RF-EMR) produced by cell phones can enhance the excitability of the brain and has recently been classified as carcinogenic. The suggested use of hands-free kits lowers the exposure to the brain, but it might theoretically increase exposure to the reproductive organs. This report summarizes the potential effects of RF-EMR on reproductive potentials in both males and females. Methods A critical review of the literature pertaining to the impact of cell phone RF-EMR on reproduction in male and female animals and humans was performed, with a focus on gonad metabolism, apoptosis of reproductive cells, fertility status, and serum reproductive hormones. Results While some animal and human studies revealed alterations in reproductive physiology in both males and females, others did not report any association. The in vitro and in vivo studies to date are highly diverse, very inconsistent in conduct and, in many cases, report different primary outcomes. Conclusion The increasing use of cell phone warrants welldesigned studies to ascertain the effect of their RF-EMR on reproduction.

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Section: Studies In Malesmentioning

confidence: 90%

Section: Studies In Malesmentioning

confidence: 99%

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Challenging cell phone impact on reproduction: A Review

Merhi

2012

J Assist Reprod Genet

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“…Bruce and Heddle (63) attributed the occurrence of sperm head abnormalities to the chromosomal aberrations that occur during the packaging of genetic material in the sperm head or occurrence of point mutation in testicular DNA. Several studies (64)(65)(66)(67) reported that abnormalities may also arise as a consequence of mistakes in the spermatozoa-differentiating process during spermatogenesis. Another two studies (66,67) reported that abnormalities in sperm heads may occur by physiological, cytotoxic or genetic mechanisms or alterations in testicular DNA which in turn disrupts the process of differentiation of spermatozoa.…”

Section: Discussionmentioning

confidence: 99%

Abnormal sperm morphology in mouse germ cells after short-term exposures to acetamiprid, propineb, and their mixture

Rasgele

2014

Archives of Industrial Hygiene and Toxicology

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Pesticides are one of the most potent environmental contaminants, which accumulate in biotic and abiotic components of ecosystems. Acetamiprid (Acm), a neonicotinoid insecticide, and Propineb (Pro), a dithiocarbamate fungicide, are widely used to control sucking insects and fungal infections on crops, respectively. The present study was undertaken to investigate the genotoxic effects of these compounds, individually and in mixtures, in mouse germ cells by using the sperm morphology assay. Mice were injected intraperitoneally with 0.625, 1.25, and 2.50 µg mL -1 of Acm, 12.5, 25, and 50 µg mL -1 of Pro, and their mixture at the same concentrations over 24 and 48 h. Acm did not significantly increase the percentage of abnormal sperm at any concentration. The frequency of abnormal sperm significantly increased after 24 and 48 h of exposure to 50 µg mL -1 of Pro. The mixtures of 2.50 µg mL -1 of Acm and 50 µg mL -1 of Pro induced sperm abnormalities antagonistically both after 24 and 48 h of exposure. Results suggest that Acm was non-genotoxic for mouse germ cells, while Pro may have been a germ cell mutagen due to the observed increase in the frequency of sperm abnormalities. However, to gain better insight into the mutagenicity and DNA damaging potential of both of these pesticides, further studies at molecular level should be done.

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“…Each group was placed in the exposure cages located below the GSM base stations at a distance of 1-50m from the base. Total exposures due to radiofrequency field strength from mobile phone base station 1, station 2 and control station, were measured with the aid of a wide spectrum Aeritalia Radiofrequency Field Strength measuring meter at distances of 0, 50, 100, 150, 200, 250 and 300m as previously described (Otitoloju et al, 2010).…”

Section: Measurement Of Radiofrequency Radiation From Gsm Base Stationsmentioning

confidence: 99%

Stimulation of Haemopoetic Activity in Bone Marrow and Deformation of Red Blood Cells in Albino Mice, <i>Mus musculus</i> Exposed to Radiations from GSM Base Stations

Otitoloju¹,

Osunkalu²,

Akogun³

et al. 2011

Sierra Leone j. biomed. res.

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The levels of radiofrequency radiations around two global systems for mobile communication (GSM) base stations located around a residential quarter and workplace complex were measured. The effects of the radiofrequency radiations on albino mice placed in exposure cages and located around the base stations over a six months period were investigated. The levels of radiofrequency (RF) radiations around the base stations were found to range between 383 mV/m to 730 mV/m compared to 59 mV/m in control stations. In the exposed mice, a pattern of pancytosis was observed and significant increases were observed in the Packed Cell Volume (PCV), White Cell Count (WBC), Platelet count (PLT) and Red Cell Count (RCC) throughout the period of exposure in both stations when compared with control values. No significant (p>0.05) differences were observed in these values when both stations were compared. After 90 days of exposure, marginal increases occurred in the mean cell volume of exposed mice at station 1 and 2 (53.1±3.6fl Vs 55.9±1.8fl and 57.9±0.25fl respectively), with the mean cell haemoglobin concentration showing significant reduction after 180 days of exposure at station 2 (27.9±2.4g/dl Vs 25.7±0.29g/dl; p<0.05). Marked anisopoikilocytosis and striking polychromasia were seen on peripheral films of exposed mice, with bone marrow showing increased cellularity. Exposure of the mice to radiofrequency radiations therefore resulted in cellular proliferation with subsequent stimulation of haemopoetic activity and probable increase in the utilisation of folate and iron resulting in increased mean cell volume (MCV) and reduction in mean cell haemoglobin concentration (MCHC). The fears of a possible biological effect of chronic human exposure to radiofrequency radiations may therefore be reasonable enough to justify the clamour for the reduction in the proliferation of GSM base stations across the country.

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Preliminary Study on the Induction of Sperm Head Abnormalities in Mice, Mus musculus, Exposed to Radiofrequency Radiations from Global System for Mobile Communication Base Stations

Cited by 55 publications

References 14 publications

Challenging cell phone impact on reproduction: A Review

Challenging cell phone impact on reproduction: A Review

Abnormal sperm morphology in mouse germ cells after short-term exposures to acetamiprid, propineb, and their mixture

Stimulation of Haemopoetic Activity in Bone Marrow and Deformation of Red Blood Cells in Albino Mice, <i>Mus musculus</i> Exposed to Radiations from GSM Base Stations

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