Preliminary study on antifertility activity of Calotropis procera roots in female rats

Antifertility Activity in the Acetone Extracts of Datura metel, L Seeds on Female Mouse

“…The administration of aqueous extract of Solanum lycocarpum fruits in male swiss mouse causes toxic effect on its reproductive system [10]. In our study, the females treated with 2% seed extract caused 100% antiimplantation activity, the same trend was also observed by Kamath and Rana [4]. They showed that the root extract of Calotropis procera cause 100% antiimplantation activity.…”

“…Chandhoke [3] suggested that the Datura lactones isolated from Datura squereifolia and its chemical compounds were evaluated for antifertility effects in female albino rats. Kamath and Rana [4], observed the strong anti-implantation and uterotropic activity of Calotropis procera extracts in ethanol against the female rat reproduction at 250 mg/kg dose. The present study is an effort to find an alternative source to control birth rate by using the extracts of Datura metel dissolved in acetone.…”

In vitro and in vivo antiproliferative activity of Calotropis procera stem extracts

“…At the last decades, C. procera received special attention, with lots of publications describing the biological activities of molecules and aqueous and organic extracts obtained from its distinct tissues (Jain et al 1996, Kamath and Rana 2002, Ahmed et al 2003, Iqbal et al 2005, Ramos et al 2006, Setty et al 2007.…”

“…Moreover, latex possess biological activity against the coccidian protozoa Eimeria ovinoidalis (Mahmoud et al 2001) and Aedes aegypti larvae (Ramos et al 2006), protection against hyperglycemia induced by alloxan (Roy et al 2005) and anti-inflammatory (Alencar et al 2004) effects. Root methanolic extracts simulates oestrogenic actions, altering uterine endometrial and interfering on the blastocyst implantation (Kamath and Rana 2002), while stem bark extracts reduces bronchial inflammation, showing antitussigene activity by oral administration (Dieye et al 1993). In this work, the great pharmacological potential of C. procera was evaluated aiming to study the in vitro cytotoxicity of stem extracts and their in vivo antitumor capacity on mice transplanted with Sarcoma 180 cells.…”

Phytochemical composition, mosquito larvicidal, ovicidal and repellent activity of <i>Calotropis procera </i> against <i>Culex tritaeniorhynchus</i> and <i>Culex gelidus</i>

“…Latex of the plant was reported to possess analgesic activity , anti-inflammatory activity (Singh et al, 2000), anti-oxidant activity (Roy et al, 2005), antidiarrhoeal activity (Kumar et al, 2001), antinociceptive activity (Soares et al, 2005) and antimalarial activity (Sharma and Sharma, 2000). Roots are reported for antifertility activity (Kamath and Rana, 2002), antitumor activity (Mathur et al, 2009) and anticonvulsant activity (Jalalpure et al, 2009). Seeds and stem are reported to possess antimicrobial activity (Kuta, 2008;Bhaskar and Ajay, 2009).…”