Preliminary study of the hypoglyncemic action of the extract of leaf of

Esyin, A O; Oforah, E; Dooka, B D

doi:10.4314/gjpas.v6i4.16180

Cited by 5 publications

(4 citation statements)

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“…Telfairia occidentalis, popularly called fluted pumpkin is found in several African countries and known in the Ghanaian language as Krobonko. The leaves, stem, seeds and roots have been studied extensively and established to possess nutritional (Arkordda, 1990), anti-inflammatory (Oluwole et al, 2003), antibacterial (Odoemena and Essien, 1995), eryhropoietic (Ajayi et al, 2000), anticholesterol (Eseyin et al, 2005), anticancer (Okokon et al, 2012;Ejike and Ezeanyika, 2011) and antidiabetic (Eseyin et al, 2000(Eseyin et al, , 2005 activities. However, very little is published on the fruit case and the pulp which according to McGrath et al (1989) represents 70 % of the weight of the whole fresh fruit.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the physicochemical properties of freeze-dried fruit pulp of Telfairia occidentalis and its potential use as suspending agent

Henry¹,

Kuntworbe²,

Michael³

et al. 2022

Heliyon

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Section: Introductionmentioning

confidence: 99%

Investigation of the physicochemical properties of freeze-dried fruit pulp of Telfairia occidentalis and its potential use as suspending agent

Henry¹,

Kuntworbe²,

Michael³

et al. 2022

Heliyon

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“…Apart from the nutritional (Okoli,et al,1983), agricultural and industrial importance (Akoroda,1990) , the plant is also medicinally useful. It possesses antiinflammatory (Oluwole,2003), antibacterial (Odoemena,1995) , erythropoietic (Ajayi et al,2000) ,anticholesterolemic (Eseyin et al,2005a),and antidiabetic (Eseyin et al, 2000;Eseyin et al,2005b) activities.…”

Section: Introductionmentioning

confidence: 99%

Biochemical changes in serum of Rat treated with aqueous extract of the fruit of Telfairia occidentalis

Eseyin¹,

Ekpo²,

Idem³

et al. 2009

African Journal of Biomedical Research

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“…They are also administered after delivery to stimulate milk secretion in women [23]. The leaves were previously shown to possess hypoglycaemic properties [24-27]. The ethanol extract of leaves, seeds and whole fruits of T. occidentalis were shown to have hypoglycaemic activity [28].…”

Section: Discussionmentioning

confidence: 99%

Anti-hyperglycaemic globulins from selected Cucurbitaceae seeds used as antidiabetic medicinal plants in Africa

Teugwa

Boudjeko

Tchinda

et al. 2013

BMC Complement Altern Med

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BackgroundThe recent epidemic of diabetes mellitus (DM) in Africa, coupled with rampant poverty, is an indication of the urgent need to develop new efficacious, cheaper and more available drugs to face this growing public health challenge. A number of plants products among which the protein-rich Cucurbitaceae seeds are commonly used in traditional medicine with increasing acclaimed efficacy against DM. The aim of this study was to analyse and evaluate the hypoglycaemic activity of storage proteins of five species of Cucurbitaceae, which include Telfairia occidentalis, Citrullus lanatus, Lagenaria siceraria, Cucumeropsis mannii and Cucurbita moschata.MethodsThe different families of storage proteins were extracted following differential solubility, and their contents were estimated using the Bradford method. The analysis of these proteins was done by electrophoresis in non-denaturing and denaturing conditions. The evaluation of hypoglycaemic properties of various globulins extracted was performed on male Wistar rats by the oral glucose tolerance test.ResultsThe results showed that among the proteins extracted, globulins constitute the most abundant class of storage proteins in all five species selected. Citrullus lanatus and Cucurbita moschata presented the highest levels of globulin (275.34 and 295.11 mg/g dry matter, respectively). The results of electrophoresis showed that all species possess acidic and neutrals albumins and globulins, with molecular weight of protein subunits ranging from 6.36-44.11 kDa for albumins, 6.5-173.86 kDa for globulins and 6.5-49.66 kDa for glutelins. The 6.36 kDa of albumin subunit protein and the 6.5 kDa of globulin subunit protein were present in all the species. The oral glucose tolerance test showed that the globulins of the seeds of all species except Cucumeropsis mannii caused significant drop in blood sugar (88 – 137.80%, compared to the controls, p<0.05).ConclusionsThese findings showed that the selected Cucurbitaceae seeds contained globulins with significant anti-hyperglycaemic activity. It is therefore highly encouraged to pursue investigations towards development of peptide-drugs and/or phytomedicines from these bioactive proteins which could be used as affordable alternative therapy against DM.

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Preliminary study of the hypoglyncemic action of the extract of leaf of

Cited by 5 publications

References 0 publications

Investigation of the physicochemical properties of freeze-dried fruit pulp of Telfairia occidentalis and its potential use as suspending agent

Investigation of the physicochemical properties of freeze-dried fruit pulp of Telfairia occidentalis and its potential use as suspending agent

Biochemical changes in serum of Rat treated with aqueous extract of the fruit of Telfairia occidentalis

Anti-hyperglycaemic globulins from selected Cucurbitaceae seeds used as antidiabetic medicinal plants in Africa

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