Biochemical changes in serum of Rat treated with aqueous extract of the fruit of Telfairia occidentalis

Eseyin, Olorunfemi A.; Ekpo, Arit; Idem, Iboro; Igboasoiyi, Arnold C.

doi:10.4314/ajbr.v9i3.48914

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…Therefore, from the results obtained so far, it could be inferred that the fruit mesocarp may not only be ineffective in ameliorating or improving anaemic conditions due to the absence of key minerals and vitamins necessary to mediate this action but might also tend to worsen the case in a diseased condition. These findings seem to be in keeping with the research of Eseyin et al [ 13 ], where it was suggested that the fruit extract may be unsafe for consumption due to its damaging effects on the rat liver and bones.…”

Section: Discussionsupporting

confidence: 92%

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Haematinic and Hepatoprotective Properties of Telfairia occidentalis Fruit Mesocarp on Phenylhydrazine-Induced Anaemia in Experimental Rats

Nneoyi-Egbe,

Onyenweaku,

Akpanukoh

et al. 2023

Biochemistry Research International

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The level and potential of iron contained in fluted pumpkin (Telfairia occidentalis) has been exploited as a blood tonic; however, the potentials of some other parts of the plant are unknown. The effect of T. occidentalis fruit mesocarp (aqueous extract) on phenylhydrazine (PHZ)-induced anaemia in experimental rats was investigated in a bid to determine its curative properties and potential in reversing haemolytic anaemia and protection of liver health. The LD50 of the fruit extract was determined using Lorke’s method for the determination of acute toxicity. The study involved oral administration of varying doses of the extract to different groups of rats which were monitored for 24 hours. The test sample did not show any signs of toxicity at doses of 5000 mg/kg b.wt, which is the highest possible recommended dose for toxicity testing. For the evaluation of the effects of the fruit extract on haematological indices and biochemical enzyme markers in anaemic rats, 30 matured albino Wistar rats were used. The rats were divided into five groups of six rats each. Group 1 consisted of normal rats (control group), Group 2 consisted of anaemic untreated rats, and Group 3 consisted of anaemic rats treated with the standard drug Astymin, while Groups 4 and 5 were made up of anaemic rats given the extract at doses of 600 mg/kg b.wt and 1000 mg/kg b.wt, respectively. The fruit extract failed to show any significant effect in improving the haemoglobin (Hb), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphate (ALP) levels in anaemic rats but rather may have contributed to a reduction in Hb levels and an unhealthy increase in serum enzyme levels. This is indicative of the apparent inability of the aqueous extract of the T. occidentalis fruit mesocarp to reverse PHZ-induced haemolytic anaemia and may suggest a possible detrimental effect of high doses of the extract over a prolonged period.

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Section: Discussionsupporting

confidence: 92%

“… Diagram of the cross-sectional area of T. occidentalis , showing the exposed fruit mesocarp (yellow part), leaves, flowers, and seeds [ 13 ]. …”

Section: Figurementioning

confidence: 99%

Haematinic and Hepatoprotective Properties of Telfairia occidentalis Fruit Mesocarp on Phenylhydrazine-Induced Anaemia in Experimental Rats

Nneoyi-Egbe,

Onyenweaku,

Akpanukoh

et al. 2023

Biochemistry Research International

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Short term effect of aqueous extracts of root, pod, and stem of <i>Telfairia occidentalis</i> on some biochemical parameters in rats

Ogbonnaya¹,

Uadia²

2014

Journal of Applied Sciences and Environmental Management

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This study investigates the effect of fourteen (14) -day administration of Telfairia occidentalis root, pod and stem aqueous extracts on rats. Sixty four (64) Wister albino rats of both sexes were assigned to sixteen (16) groups of 4 animals per group. Different groups received distilled water and, root, stem, and pod extracts at the doses of 250, 750, 1500, 2250, and 3000mg/kg of body weight. All animals were treated for 14 days and sacrificed on the 15 th day. The biochemical assay results show that the root extract caused significant decreases in the activities of alanine amino transferses (ALT) and aspartate amino transferase (AST) at lower concentrations (250mg/kg and 750mg/kg), while the stem extract showed significant increase in their activities at 3000mg/kg. The pod extract had no effect on ALT and AST. Also the stem extract showed significant increase in the activities of alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) and reduction in the concentration of serum sodium ion. Serum creatinine (not urea) was elevated when the pod extract was administered at the lowest dose (250mg/kg). Conversely, the stem extract caused a reduction in the concentration of creatinine at 250-, 750-and 1500mg/kg. There was no significant effect on serum total protein and albumin by all the extracts. The stem extract showed a significant increase in the liver-body weight ratio when administered at 750mg/kg and 1500mg/kg dosage. Thus, while Telfairia occidentalis root, pod, and stem extracts may have varying protective and toxic effects on liver and kidney function parameters, their effects may be dosage-and duration-dependent.© JASEM

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Effects Of <I>Calotropis procera</I> Latex on Biochemical and Hematological Parameters in Albino Rats

Samuel¹,

Sudi²

2020

Nig. J. Biotechnol

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Calotropis procera is a wild-growing plant that belongs to the family Asclepiadaceae, commonly found in the tropical regions and is used in the treatment of diseases such as ulcer, inflammation, wound healing, etc. This confers to the increased use of medicinal plants as the major source of traditional medicine worldwide. This study is aimed at evaluating the toxicological effects of Calotropis procera latex on biochemical and hematological parameters in albino rats with a view to understanding the safety of the latex following systemic use. Fifteen (15) albino rats were divided into five groups of three rats each. Group one served as the control, group two received 0.05 ml of the latex solution per kg body weight of the rats , group three received 0.2 ml of the latex solution per kg body weight of the rats , group four received 0.4 ml of the latex solution per kg body weight of the rats , while group five received 0.6 ml of the latex solution per kg body weight of the rats for 14 days. Biochemical evaluations revealed a significant increase in the serum levels of aspartate aminotransferase (83.33 ± 1.76c) and total bilirubin (6.27 ± 4.44b) and a progressive decrease in albumin (3.93 ± 0.04a) with increased concentration of the latex. There was no significant change in the levels of alanine aminotransferase and alkaline phosphatase in all the treated groups. Hematological analyses revealed a significant (p<0.05) decrease in packed cell volume (31.33 ± 1.76a), hemoglobin (10.43 ± 0.59a), red blood cell count (3.90 ± 0.06a) and total white blood cell count (4.10 ± 0.15a) in all the treated groups compared to the control. In conclusion, the results of this study suggest that Calotropis procera latex is relatively toxic as observed in the blood and biochemical parameters related to liver function. Hence, it is recommended that caution should be taken in its use for the treatments of diseases such as wound healing as exposure to the circulatory system can cause vulnerability to its toxic effects. Keywords: Albino rats, Toxicity, Calotropis procera, latex, biochemical, hematological parameters

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Biochemical changes in serum of Rat treated with aqueous extract of the fruit of Telfairia occidentalis

Abstract: ABSTRACT

Cited by 3 publications

References 4 publications

Haematinic and Hepatoprotective Properties of Telfairia occidentalis Fruit Mesocarp on Phenylhydrazine-Induced Anaemia in Experimental Rats

Haematinic and Hepatoprotective Properties of Telfairia occidentalis Fruit Mesocarp on Phenylhydrazine-Induced Anaemia in Experimental Rats

Short term effect of aqueous extracts of root, pod, and stem of <i>Telfairia occidentalis</i> on some biochemical parameters in rats

Effects Of <I>Calotropis procera</I> Latex on Biochemical and Hematological Parameters in Albino Rats

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