Preliminary Study of the Clinical Hypoglycemic Effects of Allium cepa (Red Onion) in Type 1 and Type 2 Diabetic patients

Eldin, Imad M. Taj; Ahmed, Elhadi M.; H.M, Abd Elwahab

doi:10.4137/ehi.s5540

Cited by 79 publications

(54 citation statements)

References 12 publications

(16 reference statements)

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“…It was also able to attenuate (37%) rise in plasma glucose 2 h after glucose ingestion (Myint et al, 2009). More recently, it was shown that intake of 100 g A. cepa can decrease FBG level and improve glucose tolerance test (GTT) in both T1D and T2D patients (Eldin et al, 2010). …”

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confidence: 99%

Best herbs for managing diabetes: a review of clinical studies

Ghorbani

2013

Braz. J. Pharm. Sci.

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Diabetes mellitus is a public health problem which leads to serious complications over time. Experimentally, many herbs have been recommended for treating diabetes. In most cases, however, the recommendations are based on animal studies and limited pieces of evidence exist about their clinical usefulness. This review focused on the herbs, the hypoglycemic actions of which have been supported by three or more clinical studies. The search was done in Google Scholar, Medline and Science Direct databases using the key terms diabetes, plants, herbs, glucose and patients. According to the clinical studies, Aegle marmelos, Allium cepa, Gymnema sylvestre, Momordica charantia, Ocimum sanctum, Nigella sativa, Ocimum sanctum, Panax quinquefolius, Salacia reticulate, Silybum marianum and Trigonella foenum-graecum have shown hypoglycemic and, in some cases, hypolipidemic activities in diabetic patients. Among them, Gymnema sylvestre, Momordica charantia, Silybum marianum and Trigonella foenum-graecum have acquired enough reputation for managing diabetes. Thus, it seems that physicians can rely on these herbs and advise for the patients to improve management of diabetes. Uniterms: Medicinal plants/diabetes treatment. Diabetes/treatment. Diabetes/clinical trials.Diabetes mellitus é um problema de saúde pública que leva a complicações graves ao longo do tempo. Experimentalmente, muitas ervas têm sido recomendadas para o tratamento da diabetes. Contudo, na maior parte dos casos as recomendações são baseadas em estudos em animais e existem evidências limitadas sobre a sua utilidade clínica. Esta revisão tem como foco as ervas nas quais as ações hipooglicêmicas são apoiadas por três ou mais estudos clínicos. Realizou-se pesquisa no Google Scholar, Medline e Science Direct utilizando palavras-chave diabete, plantas, ervas, glicose e pacientes. Segundo os estudos clínicos, Aegle marmelos, Allium cepa, Gymnema sylvestre, Momordica charantia, Ocimum sanctum, Nigella sativa, Ocimum sanctum, Panax quinquefolius, Salacia reticulate, Silybum marianum e Trigonella foenum-graecum mostraram atividade hipoglicêmica e, em alguns casos, hipolipidêmica em pacientes diabéticos. Entre elas, Gymnema sylvestre, Momordica charantia, Silybum marianum e Trigonella foenumgraecum apresentam grande reputação no manejamento da diabetes. Portanto, parece que os médicos podem confiar nessas ervas e aconselhar aos pacientes para que melhorem o tratamento da diabetes.Unitermos: Planta medicinais/tratamento da diabetes. Diabetes/tratamento. Diabetes/ensaios clínicos. INTRODUCTIONDiabetes mellitus is a growing public health problem in both developed and developing countries. According to the report of World Health Organization (August, 2011), 346 million people have diabetes worldwide. It is also estimated that 3.4 million patients died from diabetes-related complications in 2004. Without urgent action, this number is likely to double by 2030. Generally, diabetes is classified to two main types: type-1 diabetes (T1D), previously known as insulin-dependent diabet...

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confidence: 99%

Best herbs for managing diabetes: a review of clinical studies

Ghorbani

2013

Braz. J. Pharm. Sci.

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“…Several studies have also reported antidiabetic activity of onion when ingested as oils or extracts (Jung, Lim, Moon, Kim, & Kwon, 2011;Matsunaga et al, 2014;Taj Eldin, Ahmed, & Elwahab, 2010). One mechanism described in literature is the inhibition of carbohydrate-digestive enzymes by onion-extracts and flavonoids thereof that is accompanied by a diminished increase in postprandial blood glucose levels (Kang et al, 2010;Kim, Jo, Kwon, & Hwang, 2011).…”

Section: Introductionmentioning

confidence: 96%

Extracts and flavonoids from onion inhibit the intestinal sodium-coupled glucose transporter 1 (SGLT1) in vitro but show no anti-hyperglycaemic effects in vivo in normoglycaemic mice and human volunteers

Schulze¹,

Bangert²,

Schwanck

et al. 2015

Journal of Functional Foods

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“…The antidiabetic effect of A. cepa L. (Liliaceae) was evaluated in both animal models and human subjects (Taj Eldin et al, 2010). Furthermore, the role of nutritional factors in reproduction and subfertility is important.…”

Section: Allium Cepa (Alliaceae)mentioning

confidence: 99%

Protective Effect of Allium cepa (Onion) Seeds (AC) Extract on Histopathology of Testis in STZ-Induced Male Rats

Fallah

Mahabadi

et al. 2017

Int. J. Morphol.

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FALLAH, V.; MAHABADI, J. A.; MAHABADI, M. Y.; KASHANI, H. H. & NIKZAD, N.Protective effect of Allium cepa (onion) seeds (AC) extract on histopathology of testis in stz-induced male rats. Int. J. Morphol., 35(4):1517Morphol., 35(4): -1524Morphol., 35(4): , 2017. SUMMARY:The aim of the present study was to evaluate the effect of the extract of Allium cepa (Onion) seeds (AC) on morphometric and histology of testis and biochemical parameters in STZ-induced male rats. Forty adult male Wistar rats (2 month old) were allocated into four groups of control, diabetic control, diabetic treated with 200 or 400 mg/kg/day of onion seed extract. Diabetes mellitus was induced using 60 mg/kg body weight of Streptozotocin as a single intraperitoneal injection. The extract was administered by stomach gavage for 28 days. The morphometric and histological structure of the testis, biochemical factors like glucose and testosterone levels were assessed. All analyses were done at the end of the four week study period. Data were compared by using Kruskal Wallis Test, Dunnett T3 and the degree of significance was set at P < 0.05 and P < 0.01. In diabetic+200 rats, the numbers of primary spermatocytes were significantly increased. In diabetic+400 rats, seminiferous tubular diameter was significantly increased and the level of testosterone hormone and testis weight was decreased significantly. In diabetic+200 and 400 rats, the numbers of spermatid, FBS and lumen diameter were significantly increased and the numbers of spermatozoa cells, body weight and volume density (VD) % lumen were decreased. Also, the numbers of spermatid in control diabetic rats was decreased. Our finding indicated that onion seed extract might be useful as a supplementary protective agent against adverse effects of diabetes on reproductive system in diabetic men.

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Preliminary Study of the Clinical Hypoglycemic Effects of Allium cepa (Red Onion) in Type 1 and Type 2 Diabetic patients

Cited by 79 publications

References 12 publications

Best herbs for managing diabetes: a review of clinical studies

Best herbs for managing diabetes: a review of clinical studies

Extracts and flavonoids from onion inhibit the intestinal sodium-coupled glucose transporter 1 (SGLT1) in vitro but show no anti-hyperglycaemic effects in vivo in normoglycaemic mice and human volunteers

Protective Effect of Allium cepa (Onion) Seeds (AC) Extract on Histopathology of Testis in STZ-Induced Male Rats

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