Preliminary study of magnetically controlled capsule gastroscopy for diagnosing superficial gastric neoplasia

Qian, Yang‐Yang; Zhu, Shuzhen; Hou, Xi; Zhou, Wei; An, Wei; Su, Xiaoju; McAlindon, Mark E.; Li, Zhao‐Shen; Liao, Zhuan

doi:10.1016/j.dld.2018.04.013

Cited by 32 publications

(26 citation statements)

References 22 publications

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“…At present, there are many methods for screening those at high-risk of gastric cancer, such as pepsinogen combined with H. pylori antibody testing for predicting and screening [33]. OLGA staging for gastritis can also predict the risk of gastric cancer [22], magnetic capsule endoscopy is used to diagnose superficial gastric mucosal lesions [34], and gene screening [35] and vaccine development [36] are all important research methods for improving the detection rate of LGIN.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Risk Factors of Gastric Low-Grade Intraepithelial Neoplasia in Asymptomatic Subjects Undergoing Physical Examination

Liu

Cai

Chen

et al. 2020

Gastroenterology Research and Practice

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Secondary prevention is an important strategy in gastric cancer. Low-grade intraepithelial neoplasia (LGIN) is the last stage of precancerous lesion, and its timely diagnosis can greatly improve the detection rate of early gastric cancer. We performed a prospective study to analyze the risk factors of gastric LGIN in asymptomatic subjects undergoing physical examination. A total of 3437 subjects were included in this study, and 2259 asymptomatic subjects were investigated from March 2015 to April 2018. Risk factors were evaluated, and the endoscopic features of LGIN and prognosis were described. The overall incidence of LGIN was 19.73% (678/3437), while the incidence of LGIN in the asymptomatic and symptomatic groups was 19.65% (444/2259) and 19.86% (234/1178), respectively (P = 0:884). The rate of Helicobacter pylori infection in this physical examination population was 39.13% (35.8% asymptomatic group, 45.5% symptomatic group; P ≤ 0:001). Risk factors including age, H. pylori infection, history of antibiotic misuse, and spicy and high-fat diet (all P < 0:05) were further verified by multivariate analysis as independent risk factors. History of antibiotic misuse and H. pylori infection showed significant associations with LGIN (odds ratio ðORÞ = 6:767, 95% confidence interval (CI) 3.873-11.825 and OR = 3:803, 95% CI 3.009-4.808, respectively). The most common endoscopic classification of LGIN was erosive gastritis (50.78%), and the major endoscopic appearance was Paris IIa (flat with slight elevation located mostly in the antrum). During the mean follow-up period of 15.02 months, 49.4% of LGIN regressed, 0.61% of LGIN progressed, and 50% of LGIN remained unchanged. History of antibiotic misuse and H. pylori infection were predominant risk factors of LGIN in asymptomatic subjects, and those individuals should consider early screening for gastric cancer.

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Section: Discussionmentioning

confidence: 99%

Analysis of Risk Factors of Gastric Low-Grade Intraepithelial Neoplasia in Asymptomatic Subjects Undergoing Physical Examination

Liu

Cai

Chen

et al. 2020

Gastroenterology Research and Practice

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“…29,30 Moreover, it demonstrated a high sensitivity in detecting superficial gastric neoplasias. 31 Based on the valuable outcomes of these studies, a large-scale gastric cancer screening study involving 3,182 asymptomatic patients was undertaken using the robotic MCE system. In this study, gastric cancer was diagnosed in 7 people (0.22%).…”

Section: Ankon Technology Co Ltdmentioning

confidence: 99%

“…53 The most widely used CEs in the world, Pillcam SB3 (Medtronic Co., Ltd., Minneapolis, MN, USA) and Mirocam (IntroMedic), have a resolution of 320 ×320 pixels, while first-generation and second-generation MCE (Ankon Technology) have a resolution of 480 × 480 pixels and 720 × 720 pixels, respectively. 31,35,54,55 However, these CEs still have lower image resolutions than standard or high-definition wired endoscopies (400,000-1,000,000 pixels). 56 CE cannot achieve a higher resolution due to the limitations of its wireless design and small size.…”

Section: Image-enhancing Technologiesmentioning

confidence: 99%

“…In several studies conducted using the robotic MCE system, the robotic MCE system showed high diagnostic accuracy similar to EGD, but less discomfort than EGD [ 29 , 30 ]. Moreover, it demonstrated a high sensitivity in detecting superficial gastric neoplasias [ 31 ]. Based on the valuable outcomes of these studies, a large-scale gastric cancer screening study involving 3,182 asymptomatic patients was undertaken using the robotic MCE system.…”

Section: Active Locomotion Under Magnetic Controlmentioning

confidence: 99%

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A New Active Locomotion Capsule Endoscopy under Magnetic Control and Automated Reading Program

Kim²,

Lim

2020

Clin Endosc

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Capsule endoscopy (CE) is the first-line diagnostic modality for detecting small bowel lesions. CE is non-invasive and does not require sedation, but its movements cannot be controlled, it requires a long time for interpretation, and it has lower image quality compared to wired endoscopy. With the rapid advancement of technology, several methods to solve these problems have been developed. This article describes the ongoing developments regarding external CE locomotion using magnetic force, artificial intelligence-based interpretation, and image-enhancing technologies with the CE system.

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“…MGCE is much more tolerable than traditional gastroscopy for patients and can avoid adverse reactions and discomfort caused by anesthesia and surgery. Several studies have shown that MGCE provides complete visualization of all parts of the stomach [4–7] and has similar accuracy and specificity compared with traditional gastroscopy [6–10]. However, few studies have evaluated MGCE in pediatric patients.…”

Section: Introductionmentioning

confidence: 99%

Magnetically Guided Capsule Endoscopy in Pediatric Patients with Abdominal Pain

Xie

Qian

Cheng

et al. 2019

Gastroenterology Research and Practice

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Background and Aims. Magnetically guided capsule endoscopy (MGCE) offers a noninvasive method of evaluating both the gastric cavity and small intestine; however, few studies have evaluated MGCE in pediatric patients. We investigated the diagnostic efficacy of MGCE in pediatric patients with abdominal pain. Patients and Methods. We enrolled 48 patients with abdominal pain aged 6–18 years. All patients underwent MGCE to evaluate the gastric cavity and small intestine. Results. The cleanliness of the gastric cardia, fundus, body, angle, antrum, and pylorus was assessed satisfactorily in 100%, 85.4%, 89.6%, 100%, 97.9%, and 100% of patients, respectively. The subjective percentage visualization of the gastric cardia, fundus, body, angle, antrum, and pylorus was 84.8%, 83.8%, 88.5%, 87.7%, 95.2%, and 99.6%, respectively. Eighteen (37.5%) patients had 19 gastrointestinal tract lesions: one esophageal, three in the gastric cavity, and 15 in the small intestine. No adverse events occurred during follow-up. Conclusions. MGCE is safe, convenient, and tolerable for evaluating the gastric cavity and small intestine in pediatric patients. MGCE can effectively diagnose pediatric patients with abdominal pain.

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Preliminary study of magnetically controlled capsule gastroscopy for diagnosing superficial gastric neoplasia

Cited by 32 publications

References 22 publications

Analysis of Risk Factors of Gastric Low-Grade Intraepithelial Neoplasia in Asymptomatic Subjects Undergoing Physical Examination

Analysis of Risk Factors of Gastric Low-Grade Intraepithelial Neoplasia in Asymptomatic Subjects Undergoing Physical Examination

A New Active Locomotion Capsule Endoscopy under Magnetic Control and Automated Reading Program

Magnetically Guided Capsule Endoscopy in Pediatric Patients with Abdominal Pain

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