Preliminary study of a controllable device for subtenon drug infusion in a rabbit model

Duan, Yiqin; Yang, Yezhen; Huang, Xian-Ju; Lin, Ding

doi:10.1111/aos.13448

Cited by 3 publications

(1 citation statement)

References 42 publications

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“…In addition to these barriers, the feasibility of drugs to access the vitreous after periocular administration has been reported. For example, according to experimental studies in rabbit eyes, the administration of dimethyl vancomycin via sub-Tenon administration provided an effective drug concentration in the vitreous [20]. Furthermore, previous studies have shown that, after peribulbar or subconjunctival injection of dexamethasone, significant levels of the active substance can be measured in the vitreous, and these levels are achieved by direct diffusion of the drug through the sclera [21].…”

Section: Introductionmentioning

confidence: 99%

Dexamethasone PLGA Microspheres for Sub-Tenon Administration: Influence of Sterilization and Tolerance Studies

et al. 2021

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Many diseases affecting the posterior segment of the eye require repeated intravitreal injections with corticosteroids in chronic treatments. The periocular administration is a less invasive route attracting considerable attention for long-term therapies. In the present work, dexamethasone-loaded poly(lactic-co-glycolic) acid (PLGA) microspheres (Dx-MS) were prepared using the oil-in-water (O/W) emulsion solvent evaporation technique. MS were characterized in terms of mean particle size and particle size distribution, external morphology, polymer integrity, drug content, and in vitro release profiles. MS were sterilized by gamma irradiation (25 kGy), and dexamethasone release profiles from sterilized and non-sterilized microspheres were compared by means of the similarity factor (f2). The mechanism of drug release before and after irradiation exposure of Dx-MS was identified using appropriate mathematical models. Dexamethasone release was sustained in vitro for 9 weeks. The evaluation of the in vivo tolerance was carried out in rabbit eyes, which received a sub-Tenon injection of 5 mg of sterilized Dx-MS (20–53 µm size containing 165.6 ± 3.6 µg Dx/mg MS) equivalent to 828 µg of Dx. No detectable increase in intraocular pressure was reported, and clinical and histological analysis of the ocular tissues showed no adverse events up to 6 weeks after the administration. According to the data presented in this work, the sub-Tenon administration of Dx-MS could be a promising alternative to successive intravitreal injections for the treatment of chronic diseases of the back of the eye.

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Section: Introductionmentioning

confidence: 99%

Dexamethasone PLGA Microspheres for Sub-Tenon Administration: Influence of Sterilization and Tolerance Studies

et al. 2021

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Sub-Tenon Sustained Controllable Delivery of Dexamethasone for Treating Severe Acute Experimental Uveitis

Zhao

Huang

Peng

et al. 2019

Ocular Immunology and Inflammation

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Pulsed Ultrasound-Mediated Enhancement on Transscleral and Transconjunctival Fluorescein Sodium Delivery to Rabbit Eye In Vivo

You

Zhou

Yang

et al. 2023

Journal of Ocular Pharmacology and Therapeutics

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Preliminary study of a controllable device for subtenon drug infusion in a rabbit model

Abstract: Subtenon application with this novel minimally invasive design is an effective method for delivering an appropriate drug to the vitreous in a sustained and controllable amount.

Cited by 3 publications

References 42 publications

Dexamethasone PLGA Microspheres for Sub-Tenon Administration: Influence of Sterilization and Tolerance Studies

Dexamethasone PLGA Microspheres for Sub-Tenon Administration: Influence of Sterilization and Tolerance Studies

Sub-Tenon Sustained Controllable Delivery of Dexamethasone for Treating Severe Acute Experimental Uveitis

Pulsed Ultrasound-Mediated Enhancement on Transscleral and Transconjunctival Fluorescein Sodium Delivery to Rabbit Eye In Vivo

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