Preliminary Studies of the Immunomodulator Effect of the Propolis Trigona spp. Extract in a Mouse Model

Kalsum, Nurbani

doi:10.9790/2380-1002027580

Cited by 18 publications

(12 citation statements)

References 27 publications

(29 reference statements)

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“…. This study also found that propolis increased NO production in macrophages [36] . The compound in propolis of Trigona sp.…”

Section: Immunomodulatory Effects On Neutrophils Monocytes and Macrosupporting

confidence: 66%

“…Two propolis components used in this experiment, caffeic acid and quercetin, had no effect on antibody production, which can be explained by the synergetic effect of the propolis components as a whole [66] . Similarly, Kalsum et al [36] showed that extracts of propolis [37] considered the possibility that limonene, one of the most important constituents in propolis of Trigona sp.…”

Section: Immunomodulatory Effects On the Function Of T And B Lymphocymentioning

confidence: 99%

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Immunomodulatory Effects of Propolis and its Components on Basic Immune Cell Functions

Wolska¹,

Górska²,

Antosik³

et al. 2019

pharmaceutical-sciences

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Propolis is a product of the vital activity of the honey bee Apis mellifera. Bees produce propolis by mixing substances gathered from budding plants, flower buds and resinous exudates. They thus produce a material suitable for closing gaps, embalming dead insects within the beehive and protection from invasion by microorganisms and insects. This activity of propolis results from its composition. Raw propolis is typically composed of 50 % plant resins, 30 % waxes, 10 % essential and aromatic oils, 5 % pollens and 5 % other organic substances [1]. Propolis possessed a variety of biological and pharmacological effects, such as antibacterial, antioxidant, antitumour, antiinflammatory and immunomodulatory. However, propolis could not be used as a raw material, so it must be purified by extraction to remove the inert material and preserve the polyphenolic fraction, which is primarily responsible for its activity [1,2]. Generally, ethanol is the best solvent for propolis preparation, but other solvents such as ethyl ether, water, methanol and chloroform could also be used for extraction and identification of propolis constituents [3]. More than 300 different compounds have been identified in propolis, including phenols, tannins, polysaccharides, terpenes, aliphatic acids, esters, aromatic acids, fatty acids, aldehydes, amino

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“…. This study also found that propolis increased NO production in macrophages [36] . The compound in propolis of Trigona sp.…”

Section: Immunomodulatory Effects On Neutrophils Monocytes and Macrosupporting

confidence: 66%

Section: Immunomodulatory Effects On the Function Of T And B Lymphocymentioning

confidence: 99%

Immunomodulatory Effects of Propolis and its Components on Basic Immune Cell Functions

Wolska¹,

Górska²,

Antosik³

et al. 2019

pharmaceutical-sciences

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show abstract

“…Also, the data of the current work revealed that Treatment of Fusarium toxin-fed mice with PNPs (50, 200 and 400 µg/mL) for 14 days caused a statically significant rise in the number of cells from thymus, spleen, mesenteric lymph nodes and bone marrow compared with Fusarium toxin-fed mice although Fusarium toxin-fed mice treated with PNPs did not cause any significant effect on the number of cells from the PLN. The data of this study are agreed with the data of Gao et al, (2014) that indicated that propolis improved immune function in aged mice and had a direct regulatory effect on basic functional properties of immune cells as a result of its analytical components of polyphenols, flavonoids, cinnamic acid and artepillin-C. Kalsum et al, (2017) proved that terpenoid is one of the essential ingredients in bee glue increase bone marrow cellularity.…”

Section: Discussionsupporting

confidence: 90%

Untitled

2021

Pak. J. Pharm. Sci

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The nanotechnology has an important role in improving the efficacy and safety in therapy. The present study explains the antifungal and the immunomodulatory potency of propolis nanoparticles (PNPs) against Fusarium solani in Albino Mice. Disc diffusion method was used for antifungal efficacy of PNPs. Moreover, PNPs exhibited a progressive decrease in the % of viable Vero cells and suppressed the virulence factors of Fusarium saloni including adhesion and biofilm formation. In animal experiments, lymphoid cell, peritoneal phagocytes, red blood cell RBCs and white blood cell WBCs counts and the activities of T and B-lymphocytes were determined. In addition, T-cell mitogenesis cells, serum level of interleukin 2 (IL-2) and haemoglobin Hb concentration were measured. PNPs exhibited high inhibition zone with most of Fusarium solani isolates. The results indicated that treatment of mice by PNPs showed a marked rise in the number of cells from thymus, spleen, mesenteric lymph nodes and bone marrow. Furthermore, PNPs caused statistically significant raised in Hb concentration and WBCs count. These results confirmed that many biological activities attributed to PNPs and is as an adjuvant for immune enhancement.

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“…The beneficial effect of propolis may be related to its bioactive compounds such as aromatic acids, flavonoids, terpenoids, alkaloids, and polyphenols due to their immunomodulatory properties (Raphael and Kuttan, 2003). Therefore, the role of bioactive compounds in the immunological system may be explained by the fact that the EEP is able to activate macrophages, providing a first line of defense against microorganisms, promote the production of antibodies, and boost the immune response (Raphael and Kuttan, 2003;Kalsum et al 2017). Therefore, our results indicate that propolis has an immunostimulatory potential for broiler breeders.…”

Section: Discussionmentioning

confidence: 99%

Effects of raw propolis or water and ethanol extracts of propolis on performance, immune system, and some blood parameters of broiler breeders

Şahin

Öztürk

2018

R. Bras. Zootec.

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The objective of this study was to determine the effects of raw bee propolis and water or ethanol extract of propolis on growth performance, some blood parameters, and immunoglobulins in 15-20-week-old Ross-308 broiler breeders. The birds in the control were fed a diet without propolis, whereas the birds in the treatment groups were fed diets with raw propolis (RP), water (WEP), and ethanol (EEP) extract of propolis at the level of 1200, 400, and 400 ppm, respectively. Raw propolis and propolis extracts did not affect body weight gain, feed intake, feed conversion ratio, and some blood parameters, such as aspartate aminotransferase, alanine aminotransferase, total antioxidant status, triglyceride, and phosphorus. Birds fed EEP and those in control group had a lower IgA value compared with birds fed RP. Birds fed RP had higher IgM level than those of the other groups, and birds fed EEP had lower IgM level than those of control and RP-fed group. The IgY value of breeders fed EEP was higher than those of the other treatment birds, whereas that of WEP-fed birds was higher than those of control and RP treatment. The antibody levels of Anti-Newcastle disease virus and anti-infectious bursal disease virus were higher in EEP and RP-fed groups than those in the control and WEP-fed groups. The WEP decreased total oxidant status value compared with the control and RP treatments, whereas EEP and WEP increased plasma total protein and calcium contents compared with the control. The EEP increased plasma albumin content compared with RP. The addition of propolis extracts, especially WEP and EEP, to diet improves immunity and antioxidant activity, as well as enhances Ca absorption of broiler breeders.

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Preliminary Studies of the Immunomodulator Effect of the Propolis Trigona spp. Extract in a Mouse Model

Cited by 18 publications

References 27 publications

Immunomodulatory Effects of Propolis and its Components on Basic Immune Cell Functions

Immunomodulatory Effects of Propolis and its Components on Basic Immune Cell Functions

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Effects of raw propolis or water and ethanol extracts of propolis on performance, immune system, and some blood parameters of broiler breeders

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