Preliminary safety and efficacy results of laser immunotherapy for the treatment of metastatic breast cancer patients

Abstract

We report our preliminary results of a pilot clinical trial of late-stage breast cancer patients treated by laser immunotherapy (LIT), a local intervention using an 805-nm laser for non-invasive irradiation, indocyanine green for selective thermal effect, and immunoadjuvant (glycated chitosan) for immunological stimulation. Ten breast cancer patients were enrolled in this study; all the patients were considered to be out of other available treatment options. Preliminary data of toxicity tolerance was individually evaluated through physical exams and laboratory tests. Adverse reactions only occurred in the area of treatment due to photothermal injury and local administration of immunoadjuvant. No grade 3 or 4 side effects were observed. Treatment efficacy of LIT was also evaluated by physical examination and tomography. In 8 patients available for evaluation, the objective response rate was 62.5% and the clinical beneficial response rate was 75%. While the study is still ongoing, the initial outcomes of this clinical trial show that LIT is well tolerated and is of great promise in the treatment of metastatic breast cancer.

Quantification of glucose and glycerol diffusion in myocardium

“…In clinical dermatology, oncology, gastroenterology, gynecology, and other medical elds, optical methods are widely used for vessel imaging, detection, localization and treatment of malignant growths using photothermal or photodynamic therapy. Frequently, the optical methods use dyes and drugs for cell sensitizing and enhancement of the local immune status of a tissue, 1,2 therefore the development of noninvasive measurement techniques for monitoring of exogenous and endogenous (metabolic) agents in human tissues This is an Open Access article published by World Scienti¯c Publishing Company. It is distributed under the terms of the Creative Commons Attribution 3.0 (CC-BY) License.…”

Improvement of DC vaccine with ALA-PDT induced immunogenic apoptotic cells for skin squamous cell carcinoma

“…Its preclinical and preliminary clinical results showed promising outcomes [36][37][38][39]. It utilizes a local intervention to induce a systemic anti-tumor immunity, using as its mechanism in situ autologous whole-cell vaccination.…”

Monitoring tissue temperature for photothermal cancer therapy based on photoacoustic imaging: a pilot study

“…Laser immunotherapy (LIT), proposed in 1997 by Chen and co-workers [1], has shown to be a promising treatment modality for metastatic cancers in both pre-clinical and clinical studies [2][3][4][5][6]. Photothermal effect is a crucial component of LIT, by destroying tumor cells and releasing tumor antigens.…”