Preliminary results on the protective effect of (-)-edunol, a pterocarpan from Brongniartia podalyrioides (Leguminosae), against Bothrops atrox venom in mice

Effect of Annona senegalensis rootbark extracts on Naja nigricotlis nigricotlis venom in rats

“…The activity of the extract may, therefore, be linked to its tannin contents. Furthermore, phytochemical constituents of plants used for snakebites tend to have similar (isoflavone skeleton, acidic nature and deoxygenated) functions (Reyes-Chilpa et al, 1994).…”

Medicinal and ethnoveterinary remedies of hunters in Trinidad

“…utilis) that produce a dose-related increase in the clotting time of blood induced by carpet viper venom ( Echis carinatus ) would be useful against bites from Bothrops species that cause haemorrhage at the point of injection due to the inhibition of the clotting mechanism [40]. Antivenom compounds so far isolated from plants include protocatechuic acid, a catechin-gallo-catechin tannin, caffeic acid derivatives (chlorogenic acid, cynarin), coumarins (bergapten), flavonoids (rutin, isoscutellarein, kaempferol, quercetin, hesperidin), ar-turmerone, alkaloids (aristolochic acid), triterpenoids, triterpenes, coumestans (wedelolactone), sterols (sitosterol, stigmasterol, beta-amyrin), triterpenoid glycosides, alkaloids (allantoin) and lignoflavonoids [43,40,44,42]. Many relevant compounds are widely distributed nitrogen-free, low molecular weight compounds (except aristolochic acid, an untypical non-basic, nitro-derivative) [38].…”

Pterocarpans: interesting natural products with antifungal activity and other biological properties

“…Plants containing pterocarpans have been used long time ago as folk remedies in traditional medicine of many diverse cultures as oral antidote against snake venoms and spiders (Nakagawa et al 1982;Reyes-Chilpa et al 1994;Reyes-Chilpa and Jimenez-Estrada 1995;Mors et al 1989). Actually, there are different biological activities in pterocarpans that make them interesting in several lines of research, such as reverse transcriptase inhibitation and anti-HIV activity (Engler et al 1993(Engler et al , 1996Schaefer et al 1993), Barrero et al (1998) …”