Preliminary results of modified interstitial MIAMI brachytherapy applicator for treatment of upper and apical vaginal tumors

Patel, Payal; Deufel, Christopher L.; Haddock, Michael G.; Petersen, Ivy A.

doi:10.5114/jcb.2020.101689

Cited by 3 publications

(2 citation statements)

References 36 publications

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“…Patel et al . drilled holes through the apex of a Miami multichannel cylinder (Elekta, Stockholm, Sweden) in order to use the six peripheral cylinder channels as templates for IS needles [ 27 ]. Petric et al .…”

Section: Purposementioning

confidence: 99%

“…A simple low-cost approach is to modify an existing IC-only applicator for combined IC/IS BT. Patel et al drilled holes through the apex of a Miami multichannel cylinder (Elekta, Stockholm, Sweden) in order to use the six peripheral cylinder channels as templates for IS needles [27]. Petric et al drilled holes to guide IS needles on home-made ring caps designed to attach on Varian T&R IC applicators [28].…”

Section: Purposementioning

confidence: 99%

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The Montreal split ring applicator: Towards highly adaptive gynecological brachytherapy using 3D-printed biocompatible patient-specific interstitial caps

Kamio,

Roy,

Morgan

et al. 2023

jcb

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Purpose The addition of interstitial (IS) needles to intra-cavitary (IC) brachytherapy applicators is associated with improved outcomes in locally advanced cervical cancers involving parametrial tumor extensions. The purpose of this work was to validate a clinical workflow involving 3D-printed caps for a commercial IC split ring applicator that enable using IS needle trajectories tailored to each treatment. Material and methods A dedicated software module was developed in this work allowing users to design patient-specific IS caps without knowledge of computer-aided design (CAD) software. This software module was integrated to 3D Brachy, a commercial software developed by Adaptiiv Medical Technologies Inc. For validation of the workflow, CAD models of ground truth caps with five IS needle trajectories were designed with Fusion 360™, 3D-printed, assembled with a split ring applicator, and CT-scanned with radio-opaque markers. 3D Brachy was then applied to generate a replica based on trajectories reconstructed from the radio-opaque markers. A comparison between ground truth and replicated IS needle trajectories was done using intersection points with planes at the level of the cervix (z = 0 cm) and a representative needle depth (z = 3 cm). Results Prototypes of interstitial caps 3D-printed in both BioMed Amber and BioMed Clear SLA resins were tested to be functional both pre- and post-sterilization for IS needles with obliquity angles ≤ 45°. Distance-to-agreement at z = 0 cm and 3 cm as well as deviations in pitch and yaw angles of the five IS needle trajectories were found to have mean values of 3.3 ±2.1 mm, 7.3 ±2.0 mm, 2.9° ±2.3°, and 7.0° ±7.0°, respectively. Conclusions The clinical workflow for image-guided adaptive cervical cancer brachytherapy using the Montreal split ring applicator was validated.

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Section: Purposementioning

confidence: 99%

Section: Purposementioning

confidence: 99%

The Montreal split ring applicator: Towards highly adaptive gynecological brachytherapy using 3D-printed biocompatible patient-specific interstitial caps

Kamio,

Roy,

Morgan

et al. 2023

jcb

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GEC-ESTRO (ACROP)–ABS–CBG Consensus Brachytherapy Target Definition Guidelines for Recurrent Endometrial and Cervical Tumors in the Vagina

Kamrava¹,

Leung²,

Bachand³

et al. 2023

International Journal of Radiation Oncology*Biology*Physics

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Dose-response relationship between volume base dose and tumor local control in definitive radiotherapy for vaginal cancer

Wang,

Guo,

Zhao

2024

BMC Cancer

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Objective This study aimed to establish the dose-response relationship between volume base dose and tumor local control for vaginal cancer, including primary vaginal cancer and recurrent gynecologic malignancies in the vagina. Materials and methods We identified studies that reported volume base dose and local control by searching the PubMed, the Web of Science, and the Cochrane Library Database through August 12, 2023. The regression analyses were performed using probit model between volume based dose versus clinical outcomes. Subgroup analyses were performed according to stratification: publication year, country, inclusion time of patients, patients with prior radiotherapy, age, primaries or recurrent, tumor size, concurrent chemoradiotherapy proportion, dose rate, image modality for planning, and interstitial proportion. Results A total of 879 patients with vaginal cancer were identified from 18 studies. Among them, 293 cases were primary vaginal cancer, 573 cases were recurrent cancer in the vagina, and 13 cases were unknown. The probit model showed a significant relationship between the HR-CTV (or CTV) D90 versus the 2-year and 3-year local control, P values were 0.013 and 0.014, respectively. The D90 corresponding to probabilities of 90% 2-year local control were 79.0 GyEQD2,10 (95% CI: 75.3–96.6 GyEQD2,10). Conclusions A significant dependence of 2-year or 3-year local control on HR-CTV (or CTV) D90 was found. Our research findings encourage further validation of the dose-response relationship of radical radiotherapy for vaginal cancer through protocol based multicenter clinical trials.

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Preliminary results of modified interstitial MIAMI brachytherapy applicator for treatment of upper and apical vaginal tumors

Cited by 3 publications

References 36 publications

The Montreal split ring applicator: Towards highly adaptive gynecological brachytherapy using 3D-printed biocompatible patient-specific interstitial caps

The Montreal split ring applicator: Towards highly adaptive gynecological brachytherapy using 3D-printed biocompatible patient-specific interstitial caps

GEC-ESTRO (ACROP)–ABS–CBG Consensus Brachytherapy Target Definition Guidelines for Recurrent Endometrial and Cervical Tumors in the Vagina

Dose-response relationship between volume base dose and tumor local control in definitive radiotherapy for vaginal cancer

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