Preliminary Results After Application of Absorbable Metal Stents in Patients With Critical Limb Ischemia

Peeters, Patrick; Bosiers, Marc; J, Verbist; Deloose, Koen; Heublein, B

doi:10.1583/04-1349r.1

Cited by 241 publications

(114 citation statements)

References 10 publications

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“…[1][2][3][4][5][6][7][8] Degradation of bioabsorbable metals should be arrested until the fractured bone is sufficiently repaired to bear the load. However, the existing magnesium alloys do not show enough corrosion resistance for bone fixation devices.…”

Section: Introductionmentioning

confidence: 99%

Corrosion Behavior of Magnesium with Hydroxyapatite Coatings Formed by Hydrothermal Treatment

Hiromoto

Tomozawa

2010

Mater. Trans.

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Corrosion resistance of magnesium alloys must be improved for their applications to orthopaedic bioabsorbable devices. Since hydroxyapatite (HAp) is chemically stable in the body and is the main component of bones, HAp coatings have been well studied to improve the corrosion resistance and osteoconductivity of magnesium alloys. In this study, highly crystallized HAp coatings were formed on pure magnesium with a single-step hydrothermal treatment using a C 10 H 12 CaN 2 Na 2 O 8 solution with various pH values. Morphology of the HAp coating varied depending on the pH value. Corrosion behavior of the HAp-coated magnesium was investigated by anodic polarization, impedance and immersion tests in a simulated body fluid. It was revealed that the corrosion resistance of pure magnesium was improved more than 10 times with the HAp coatings. Stable localized corrosion was prevented with the HAp coatings although the occurrence and moderation of unstable localized corrosion appeared to take place at the defects of the HAp coatings. The initial protectiveness of the HAp coating depended on the treatment condition. During 4-day immersion, the precipitated HAp sealed the defects of the HAp coatings, resulting in the negligible release of magnesium ions regardless of the treatment conditions.

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Section: Introductionmentioning

confidence: 99%

Corrosion Behavior of Magnesium with Hydroxyapatite Coatings Formed by Hydrothermal Treatment

Hiromoto

Tomozawa

2010

Mater. Trans.

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“…This was not part of the goals for this study, and has been studied extensively elsewhere [50][51][52][53][54][55][56]. The Mg alloy selected, however, was based on favorable results from these in vivo studies.…”

Section: Discussionmentioning

confidence: 99%

A Strategy to Optimize Recovery in Orthopedic Sports Injuries

Sealy¹,

Liu²,

Li³

et al. 2017

J Bioanal Biomed

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An important goal for treatment of sports injuries is to have as short a recovery time as possible. The critical problem with current orthopedic implants is that they are designed to be permanent and have a high complication rate (15%) that often requires removal and replacement with a second surgery; and subsequently a second rehabilitation cycle. This study tests the feasibility of having a device that provides the needed mechanical properties, to promote healing for a specified amount of time and then degrades away to shorten recovery time. The specific strategy was to create a surface layer on a degradable metal alloy with a controllable degradation rate. Previous studies have shown the feasibility of using surface treatments to alter the surface integrity (i.e., topography, microhardness, and residual stress) leading to increased fatigue strength and a decreased degradation rate. This study was an extension of these previous studies to look at the changes in surface integrity and mechanical properties initially as well as the degradation over time for two surface treatments (shot peening and burnishing). Although the treatments improved initial properties and the burnishing treatment slowed the degradation rate, the faster degradation of the base material in vitro (compared to previous studies) probably reduced the overall impact. The study helped support the feasibility of this approach by showing the ability of the surface treatment to modify surface integrity, initial mechanical properties, and degradation rate; the degradation rate of the base material used needs to be slower and/or the surface treatment needs to create a bigger change in the degradation rate. Further it ultimately needs to be shown that the surface treatment can produce a material that will allow orthopedic devices to meet the required clinical design constraints in vivo.

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“…From 2005 to 2007 AMS1 was tested in humans treating lower limb arteries in adults (36)(37)(38) as well as aorta and pulmonary arteries in pediatric patients (39)(40)(41).…”

Section: Resorption Processmentioning

confidence: 99%

Magmaris: a new generation metallic sirolimus-eluting fully bioresorbable scaffold: present status and future perspectives

Rapetto¹,

Leoncini²

2017

J. Thorac. Dis.

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Drug-eluting stents (DES) have reached a high safety and efficacy profile, becoming the best option for percutaneous coronary interventions (PCI) based revascularization. However, despite their optimal performance, a few concerns remain regarding their use, mainly due to permanent caging of the vessels and its consequences, first of all late stent thrombosis (ST). Bioresorbable scaffolds (BRS) aim to overcome these issues. The results achieved in randomized controlled trials (RCT) by the first generation of poly-L-lactic acid (PLLA) based scaffolds were promising at 1 year, but the first long term reports (albeit flawed by nonoptimal implantation technique) have been disappointing, showing, for instance, an increased risk of ST and target vessel myocardial infarction (TV-MI). In such a scenario the advent of a newer generation magnesium (Mg) based BRS is welcome, mainly because of its innovative mechanical and chemical features coupled with well proven biocompatibility. Despite being in its infancy, this technology seems to promise a great potential.In our article, we review the Magmaris (Biotronik AG, Bülach, Switzerland) Mg BRS development from animal models to human use, underscore its best qualities and weaknesses, and provide hints of its possible future perspectives.

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Preliminary Results After Application of Absorbable Metal Stents in Patients With Critical Limb Ischemia

Abstract: After 3 months, the primary clinical patency and limb salvage rates suggest a potentially promising performance of these AMS devices in the treatment of below-knee lesions in CLI patients.

Cited by 241 publications

References 10 publications

Corrosion Behavior of Magnesium with Hydroxyapatite Coatings Formed by Hydrothermal Treatment

Corrosion Behavior of Magnesium with Hydroxyapatite Coatings Formed by Hydrothermal Treatment

A Strategy to Optimize Recovery in Orthopedic Sports Injuries

Magmaris: a new generation metallic sirolimus-eluting fully bioresorbable scaffold: present status and future perspectives

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