Preliminary Report on the Effects of Propolis on Wound Healing in the Dental Pulp

Abstract

The purpose of this investigation was to determine the antimicrobial and healing potential of propolis on direct dental pulp exposures. This study used 25 adult male rats. Pulp expo­sures were performed and animals were allocated to propolis and calcium hydroxide (Ca(OH)2 groups. Animals were killed on days 5, 7, 10, and 14. The teeth were routinely processed for histological evaluation. Non-parametric tests were employed to analyze the data. No significant differences were found between study groups on the wound healing of the dental pulp. Both substances were com parable in exhibiting normal reorganization of the pulp and no increased vascularity, and were equally efficacious in maintaining a low inflammatory and microbial cell population as well as in stimulating the formation of reparative dentin.

Assessment of ion diffusion from a calcium hydroxide-propolis paste through dentin

“…Even though the diffusion ability of the propolis-containing paste was similar to that of the saline-and propylene glycol-containing pastes, propolis may be a better indication because it adds to the antimicrobial action of calcium hydroxide. [11][12][13][14] Further studies are warranted to investigate the biocompatibility of this paste and confirm the use of propolis without alcohol as a vehicle for calcium hydroxide.…”

“…10,11 In addition to its antibacterial and anti-inflammatory action, propolis promotes tissue reorganization. 10 It is also biocompatible with pulp tissue 11 and exerts antimicrobial action against endodontic pathogens.…”

In vitro antimicrobial activity of endodontic pastes with propolis extracts and calcium hydroxide: a preliminary study

“…Studies on propolis applications have increased because of its therapeutic and biological properties (5,6). Current research involving propolis in dentistry spans many fields and highlights its antimicrobial and antiinflammatory activities, particularly in cariology, oral surgery, pathology, periodontics and endodontics (5,(7)(8)(9).…”

Vi̇tal Pulpa Tedavi̇leri̇nde Güncel Yaklaşimlar

“…İLLOPROST Prostasiklin; vasküler endotelyal büyüme faktö-rü salınımını stimule ederek anjiogenezi ve hücresel farklılaşmayı arttıran güçlü bir vazodilatatördür. 86,87 İlloprost ise pulmoner hipertansiyon tedavisinde kullanılan bir prostasiklin analoğudur. 88 Limjeerajarus ve ark.…”