In vitro antimicrobial activity of endodontic pastes with propolis extracts and calcium hydroxide: a preliminary study

Rezende, Giovanna Pires da Silva Ribeiro de; Costa, Luciane Rezende; Pimenta, Fabiana Cristina; Baroni, Daniela

doi:10.1590/s0103-64402008000400003

Cited by 55 publications

(50 citation statements)

References 14 publications

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“…This characteristic combined with its antimicrobial action (14) and capacity to diffuse through the dentinal tubules (15), support its indication as an intracanal medication. Further confirmatory in vivo studies as well as studies on necrotic teeth and/or with periapical lesions should be conducted to substantiate the clinical use of this paste.…”

Section: Discussionmentioning

confidence: 89%

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Biocompatibility of a Calcium Hydroxide-Propolis Experimental Paste in Rat Subcutaneous Tissue

et al. 2014

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Intracanal medications are fundamental for disinfection of the root canal system and participate in periapical repair, so their biocompatibility is of utmost importance to avoid tissue damage. This study evaluated the biocompatibility of a experimental paste of calcium hydroxide and propolis in the subcutaneous tissue of rats. The study was conducted on 15 male Wistar rats. Two incisions were made on the dorsal region of each animal for introduction of 4 tubes: one tube was empty; one contained zinc oxide-eugenol cement, and the two other tubes were filled with experimental paste. After 7, 14 and 30 days, the animals were euthanized and the specimens were subjected to histotechnical preparation. The hematoxylin and eosin-stained histological sections were analyzed by light microscopy. Scores were established according to the inflammatory process and statistically compared by the Tukey test (α=5%). The analysis of histological sections showed non-significant or mild inflammatory reaction in the connective tissue in contact with the empty tubes in all study periods while the contact of subcutaneous tissue with zinc oxide-eugenol elicited moderate or severe inflammation similarly without significant difference among the study periods. The connective tissue was moderately inflamed at 7 days when contacting the experimental paste, but the inflammatory process was non-significant or mild at 14 and 30 days. The experimental paste was biocompatible with the tissues after 14 days of subcutaneous implantation.

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Section: Discussionmentioning

confidence: 89%

“…de Rezende et al (14) evaluated the antimicrobial capacity of a CH and propolis pastes: paste 1 (propolis ethanol extract + CH) and paste 2 (non-alcoholic propolis extract + CH). The authors observed that the pastes were effective, with larger zones of microbial growth inhibition around paste 2.…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility of a Calcium Hydroxide-Propolis Experimental Paste in Rat Subcutaneous Tissue

et al. 2014

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“…Their resistance to Ca(OH) 2 reportedly stemmed from their abilities to survive in a high-pH environment 5,18) and to invade dentinal tubules and adhere to collagen in the presence of human serum 19) . Propolis, a centuries-old natural antibiotic, has also been used as an intracanal medicament because of its good antimicrobial activity against a wide range of bacterial species [20][21][22][23] . Therefore, propolis could be used as an alternative intracanal medicament in cases of persistent endodontic infections.…”

Section: Discussionmentioning

confidence: 99%

Effects of calcium hydroxide and propolis intracanal medicaments on bond strength of resin-based endodontic sealer as assessed by push-out test

2013

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The aim of this study was to investigate the effects of calcium hydroxide (Ca(OH) 2 ) and propolis intracanal medicaments on bond strength of AH Plus to root dentin. After chemomechanical instrumentation using Revo-S rotary system, three groups of root canal specimens were prepared: 10 root canals were left untreated as controls (G1), 10 received Ca(OH) 2 intracanal medicament (G2), and another 10 received propolis intracanal medicament (G3). Canals were obturated with AH Plus and gutta-percha. After bond strength evaluation using micro push-out test, data were analyzed using ANOVA and Tamhane's test (p=0.05). At coronal and middle thirds, there were no significant differences in bond strength among the three groups (p>0.05). At apical third, G3 was significantly superior to G2 (p<0.05) and G1 (p<0.05), but there was no significant difference between G2 and G1 (p>0.05). Therefore, when AH Plus was used as the sealer in endodontic treatments, its combined use with propolis as an intracanal medicament seemed to result in favorable sealer-dentin interfacial bond strength.

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“…14,15 Owing to the antimicrobial and anti-inflammatory properties of propolis, its association with calcium hydroxide has been suggested for use as a root canal dressing. De Rezende et al 16 evaluated two propolis pastes (with and without alcohol) associated to calcium hydroxide. Even though both pastes were found to display antimicrobial action, the nonalcoholic paste produced greater inhibition halos than the paste with alcohol.…”

Section: -13mentioning

confidence: 99%

Assessment of ion diffusion from a calcium hydroxide-propolis paste through dentin

Montero¹,

Mori²

2012

Braz. oral res.

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This study evaluated the ability of ions from a non-alcoholic calcium hydroxide-propolis paste to diffuse through dentinal tubules. Thirty-six single-rooted bovine teeth were used. The tooth crowns were removed, and the root canals were instrumented and divided into 3 groups: Group 1 -calcium hydroxide-propylene glycol paste; Group 2 -calcium hydroxide-saline solution paste; Group 3 -calcium hydroxide-propolis paste. After the root canal dressings were applied, the teeth were sealed and placed in containers with deionized water. The pH of the water was measured after 3, 24, 72 and 168 hours to determine the diffusion of calcium hydroxide ions through the dentinal tubules. All of the pastes studied promoted the diffusion of calcium hydroxide ions through the dentinal tubules. Associating propolis to calcium hydroxide resulted in a pH increase, which occurred with greater intensity after 72 hours. The calcium hydroxide-propolis paste was able to diffuse in dentin.

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In vitro antimicrobial activity of endodontic pastes with propolis extracts and calcium hydroxide: a preliminary study

Cited by 55 publications

References 14 publications

Biocompatibility of a Calcium Hydroxide-Propolis Experimental Paste in Rat Subcutaneous Tissue

Biocompatibility of a Calcium Hydroxide-Propolis Experimental Paste in Rat Subcutaneous Tissue

Effects of calcium hydroxide and propolis intracanal medicaments on bond strength of resin-based endodontic sealer as assessed by push-out test

Assessment of ion diffusion from a calcium hydroxide-propolis paste through dentin

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