Preliminary Report of a Nationwide Case-Control Study for Identifying Risk Factors of Tuberculosis Following Renal Transplantation

Basiri, Abbas; Moghaddam, S.M.M. Hosseini; Simforoosh, N.; Einollahi, Behzad; Hosseini, M.; Foirouzan, A.; Pour-Reza-Gholi, Fatemeh; Nafar, Mohsen; Zargar, Moosa; Pourmand, Gholamreza; Tara, Ahmad; Mombeni, H.; Moradi, Mahmoud Reza; Taghizadeh, Ali; Gholamrezaee, H.R.; Bohlouli, Abolfazl; Nezhadgashti, H; Amirzadehpasha, A.; Ahmad, Ejaz; Salehipour, Mehdi; Yazdani, Maryam; Nasrollahi, Alireza; Falaknazi, K; Mahdavi, Maryam; Shamsa, Ali; Feizzadeh, Behzad; Mojahedi, Morteza; Oghbaee, N.; Azad, Raman; Mohammadi, Zahed

doi:10.1016/j.transproceed.2005.07.041

Cited by 41 publications

(35 citation statements)

References 8 publications

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“…Similar to the scientific literature, [23][24][25][26] the urinary tract was the most-common site of infection in our patients. The prevalence of posttransplant tuberculosis in the present study (1.67%) was within the range reported from other investigations in Iran (1% to 1.4%) 27,28 and Europe (1% to 4%). 29 Posttransplant diabetes mellitus (PTDM) is a common and serious complication of kidney transplant.…”

Section: Discussionsupporting

confidence: 87%

Adverse Reactions of Immunosuppressive Drugs in Iranian Adult Kidney Transplant Recipients

Namazi¹,

Sagheb²,

Karimzadeh³

2012

Exp Clin Transplant

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Objectives: To evaluate the pattern of immunosuppressive drug adverse reactions in adult kidney transplant recipients in Iran Materials and Methods: Adult kidney transplant outpatients under immunosuppressive therapy were recruited into the study. All adverse drug reactions to immunosuppressants and their relevant clinical and paraclinical characteristics were recorded. Causality assessment was performed by the Naranjo algorithm. The seriousness of adverse drug reactions was determined by the World Health Organization definition. The Schumock and Thornton questionnaire was used to assess the preventability of adverse drug reactions. Statistical analyses were performed. Results: A total of 1100 adverse drug reactions were detected from 120 kidney transplant recipients. Increased appetite (9.09%) was the adverse reaction reported most frequently. Causality assessment revealed that 1019 adverse drug reactions (92.64%) were possible. Forty adverse drug reactions (3.64%) were identified as serious. Six hundred seventy-one adverse drug reactions (61%) were preventable. Posttransplant duration was significantly correlated with the number of adverse drug reactions (R=0.19; P = .035). Conclusions: All renal allograft recipients experienced at least 1 immunosuppressant-related adverse reaction. Prolongation of immunosuppressive treatment resulted in an increase in adverse drug reactions.

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Section: Discussionsupporting

confidence: 87%

Adverse Reactions of Immunosuppressive Drugs in Iranian Adult Kidney Transplant Recipients

Namazi¹,

Sagheb²,

Karimzadeh³

2012

Exp Clin Transplant

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“…Duration of pretransplant hemodialysis, number of posttransplant rejection episodes, cyclosporine, diabetes, and chronic liver disease have been implicated as risk factors for posttransplant tuberculosis [2,22]. Of these, data from India have suggested use of cyclosporine to be the strongest risk factor [2].…”

Section: Discussionmentioning

confidence: 99%

Renal allograft tuberculosis: report of three cases and review of literature

et al. 2009

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Renal transplant recipients are prone to a variety of infections due a persistent immunodepleted state. Incidence of tuberculosis in this population is much higher compared with the general population. While pulmonary tuberculosis still remains the commonest form in this population, renal allograft tuberculosis is very rare. We report two cases of isolated allograft tuberculosis and one case of allograft tuberculosis with coexistent pleuro-pulmonary and bone marrow involvement. All three cases had presented with pyrexia of unknown origin, wherein despite extensive investigations the cause was not found. In two cases the diagnosis was confirmed on histology. Two cases responded to non-rifampicin-based modified antitubercular treatment and one to conventional four-drug Rifampicin-based regimen. Graft function improved in two cases while in one case the graft was lost. Tuberculosis involving the renal allograft is a potential cause for graft dysfunction/loss and requires a high index of suspicion for diagnosis. Timely detection and early institution of therapy can help save the renal allograft.

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“…The main findings were fever, anorexia, weight loss, and palpable lymphadenopathy. 41 Basiri and others 42 conducted a retrospective study comparing 120 patients who had TB after renal transplantation (study group) with 440 patients without TB (control group). Both groups underwent transplantation during 1984-2003 in Iran.…”

Section: Tuberculosis and Transplantationmentioning

confidence: 99%

“…The main radiologic abnormalities found in both groups were apical infiltration and cavities (57.2% versus 0.2%), pleural effusion (22% versus 0%), and a milliary pattern (11.7% versus 0%). 42 Patients with a history of TB during dialysis have a higher risk for developing post-transplantation TB. It is important to consider that because of immunosuppression, a delay in diagnosis can occur because of false-negative PPD skin tests results; 29% of transplantation patients have Tb caused by environmental Mycobacterium spp.…”

Section: Tuberculosis and Transplantationmentioning

confidence: 99%

Renal Tuberculosis in the Modern Era

Daher¹,

Silva²,

Barros³

2013

The American Society of Tropical Medicine and Hygiene

110

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Abstract. Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis. The disease remains as an important public health problem in developing countries. Extrapulmonary TB became more common with the advent of infection with human immunodeficiency virus and by the increase in the number of organ transplantation, which also leads to immunosuppression of thousand of persons. Urogenital TB represents 27% of extrapulmonary cases. Renal involvement in TB can be part of a disseminated infection or a localized genitourinary disease. Renal involvement by TB infection is underdiagnosed in most health care centers. Most patients with renal TB have sterile pyuria, which can be accompanied by microscopic hematuria. The diagnosis of urinary tract TB is based on the finding of pyuria in the absence of common bacterial infection. The first choice drugs include isoniazide, rifampicin, pirazinamide, ethambutol, and streptomycin. Awareness of renal TB is urgently needed by physicians for suspecting this disease in patients with unexplained urinary tract abnormalities, mainly in those with any immunosuppression and those coming from TB-endemic areas.

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Preliminary Report of a Nationwide Case-Control Study for Identifying Risk Factors of Tuberculosis Following Renal Transplantation

Cited by 41 publications

References 8 publications

Adverse Reactions of Immunosuppressive Drugs in Iranian Adult Kidney Transplant Recipients

Adverse Reactions of Immunosuppressive Drugs in Iranian Adult Kidney Transplant Recipients

Renal allograft tuberculosis: report of three cases and review of literature

Renal Tuberculosis in the Modern Era

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