Renal allograft tuberculosis: report of three cases and review of literature

Khaira, Ambar; Bagchi, Soumita; Sharma, Alok; Mukund, Amar; Mahajan, Sandeep; Bhowmik, D; Dinda, Amit Kumar; Agarwal, Sanjay Kumar

doi:10.1007/s10157-009-0158-6

Cited by 17 publications

(18 citation statements)

References 19 publications

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“…Common clinical abnormalities include pyrexia, pulmonary infiltrates, exudative pleural effusion, and exudative ascites. In our study, moderate and permanent fever of unknown origin was observed in 93,7% of cases versus 71% to 82,9% in the literature [4,[25][26][27]. Impairment of the general state was observed in 31,2% patients in our study versus 40% in literature [27,28].…”

Section: Discussioncontrasting

confidence: 43%

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Mycobacterium Tuberculosis Infection Following Kidney Transplantation

Boubaker¹,

Abderrahim²,

Abdallah³

et al. 2013

AJIDM

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Introduction and Aims. Post-transplant tuberculosis (TB) is a problem in successful long-term outcome of renal transplantation recipients. Our objective was to describe the pattern and risk factors of TB infection and the prognosis in our transplant recipients. Patients and Methods. This study was a retrospective review of the records of 491 renal transplant recipients in our hospital during the period from January 1986 to December 2009. The demographic data, transplant characteristics, clinical manifestations, diagnostic criteria, treatment protocol, and long-term outcome of this cohort of patients were analyzed. Results. 16 patients (3,2%) developed post-transplant TB with a mean age of 32,5 ± 12,7 (range: 13-60) years and a mean post-transplant period of 36,6months (range: 12,3 months-15,9 years). The forms of the diseases were pulmonary in 10/16 (62,6%), disseminated in 3/16 (18,7%), and extrapulmonary in 3/16 (18,7%). Graft dysfunction was observed in 7 cases (43,7%) with tissue-proof acute rejection in 3 cases and loss of the graft in 4 cases. Hepatotoxicity developed in 3 patients (18,7%) during treatment. Recurrences were observed in 4 cases after early stop of treatment. Two patients (12.5%) died. Conclusion. Extra pulmonary and disseminated tuberculosis were observed in third of our patients. More than 9months of treatment may be necessary to prevent recurrence.

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Section: Discussioncontrasting

confidence: 43%

“…Anti-TB treatment can induce a successful management with reduction of allograft nephropathy, graft nephrectomy, and mortality [2,25,53,54]. Response to antiTB treatment should be considered to make a diagnosis among patients highly suspected of TB infections.…”

Section: Discussionmentioning

confidence: 99%

Mycobacterium Tuberculosis Infection Following Kidney Transplantation

Boubaker¹,

Abderrahim²,

Abdallah³

et al. 2013

AJIDM

View full text Add to dashboard Cite

show abstract

“…Common clinical abnormalities include pyrexia, pulmonary infiltrates, exudative pleural effusion, and exudative ascites. In our study, moderate and permanent fever of unknown origin was observed in 93,7% of cases versus 71% to 82,9 % in literature [4,25,26,27]. Impairment of the general state was observed in 31,2% patients in our study versus 40 % in literature [27,28].…”

Section: Disscussioncontrasting

confidence: 42%

“…The allograft biopsy is helpful when other investigations are inconclusive with symptoms of allograft dysfunction [2]. Histology shows, in this form, granuloma suggestive of TB [2,25,39].…”

Section: Disscussionmentioning

confidence: 99%

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Mycobacterium Tuberculosis Infection Following Kidney Transplantation

Boubaker¹,

Abderrahim²,

Abdallah³

et al. 2013

AJMSM

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Tuberculosis (TB) is one of the major causes of morbidity and mortality worldwide. Post-transplant TB is a problem in successful long-term outcome of renal transplantation recipients. It is a life-threatening opportunistic infection that is frequently encountered, but the diagnosis is often delayed. With the emergence of newer potent immunosuppressive regimens and an increased incidence of TB in the general population, post-transplant TB among transplant recipients can be anticipated. Our objective was to describe the pattern and risk factors of TB infection, and the prognosis in our transplant recipients. This study was a retrospective review of the records of 491 renal transplant recipients in our hospital during the period from January 1986 to December 2009. The demographic data, transplant characteristics, clinical manifestations, diagnostic criteria, treatment protocol, and long-term outcome of this cohort of patients were analyzed. 16 patients (3.2%) developed posttransplant TB with a mean age of 32.5 ± 12.7 (range: 13-60) years and a mean post-transplant period of 36,6 months (range: 12,3 months -15.9 years). The forms of the diseases were pulmonary in 10 /16 (62.6%), disseminated in 3/16 (18.7%) and extrapulmonary in 3/16 (18.7%). All patients initially received 4-drug combination therapy. Because of drug interaction, an increase in the dose of calcineurium inhibitor and steroid was done in 2 cases and in steroids alones in 1 case. Graft dysfunction was observed in 7 cases (43,7%) with tissue-proof acute rejection in 3 cases and loss of the graft in 4 cases. Hepatotoxicity developed in 3 patients (18.7%) during treatment. Reccurence were observed in 4 cases after early stop of treatment. Two patients (12.5%) died. Extrapulmonary and disseminated tuberculosis were observed in third of our patients. More than 9 months of treatment may be necessary to prevent recurrence.

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Epidemiology of Urogenital Tuberculosis as a Part of Extrapulmonary Tuberculosis

Kulchavenya

2013

Urogenital Tuberculosis: Epidemiology, Diagnosis, Therapy

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Renal allograft tuberculosis: report of three cases and review of literature

Cited by 17 publications

References 19 publications

Mycobacterium Tuberculosis Infection Following Kidney Transplantation

Mycobacterium Tuberculosis Infection Following Kidney Transplantation

Mycobacterium Tuberculosis Infection Following Kidney Transplantation

Epidemiology of Urogenital Tuberculosis as a Part of Extrapulmonary Tuberculosis

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