Preliminary report: circulating levels of the adipokine vaspin in gestational diabetes mellitus and preeclampsia

Stepan, Holger; Kralisch, Susan; Klostermann, K.; Schrey, S; Reisenbüchler, C; Verlohren, Michael; Verlohren, Hans-Joachim; Drynda, Kathrin; Blüher, Matthias; Stümvoll, Michael; Kratzsch, Jürgen; Kovacs, Peter; Faßhauer, Mathias

doi:10.1016/j.metabol.2009.11.001

Cited by 33 publications

(33 citation statements)

References 15 publications

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“…This finding seems to be reasonable since both of them are insulin-sensitizing adipokines. In the only other study reporting circulating levels of vaspin in normal pregnant women, no correlation with adiponectin levels was found (19). In non-pregnant populations, conflicting data exist in the literature, with reports about both negative (10) and no correlation (11) between vaspin and adiponectin, in contrast to our findings.…”

Section: Discussioncontrasting

confidence: 99%

“…Furthermore, Seeger et al (15) found no association between vaspin and BMI or insulin sensitivity in patients on chronic hemodialysis. Finally, the lack of correlation between vaspin and parameters of insulin sensitivity in our data is in accordance with the only other study evaluating circulating vaspin levels in pregnant women (19). Serum TC and TG concentrations are expected to increase markedly during pregnancy (21).…”

Section: Discussionsupporting

confidence: 92%

“…However, in an animal model, vaspin levels did not change throughout pregnancy (18). The only study evaluating circulating vaspin levels in pregnant women reported no correlation between vaspin and parameters of insulin sensitivity or lipid metabolism (19). In the same study, vaspin levels were similar between women with gestational diabetes and normal pregnancy.…”

Section: Introductionmentioning

confidence: 83%

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Serum vaspin levels in normal pregnancy in comparison with non-pregnant women

Giomisi

Kourtis

Toulis

et al. 2011

European Journal of Endocrinology

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Objective: Pregnancy represents a state of insulin resistance (IR). Vaspin (SERPINA12) is a novel insulin-sensitizing adipokine that might be implicated in endogenous glucose regulation. However, its role in pregnancy and its circulating levels have not been adequately studied. We aimed to evaluate serum vaspin levels in pregnancy and their correlation with known markers of IR. Design: A group of 106 women (age 27.9G0.4 years) at the 24-30th week of gestation (pregnancy group) and another 106 age-matched healthy non-pregnant controls (control group) were included in the study. Methods: Serum glucose, insulin, vaspin, adiponectin, and lipid parameters were measured. The quantitative insulin sensitivity check index (QUICKI) was used as an insulin sensitivity index. Results: Pregnant women had significantly higher body mass index (BMI), lipids, and serum insulin and lower serum glucose and vaspin levels than controls. Vaspin was positively correlated to adiponectin in both groups (P!0.001 and P!0.004 respectively) but was not correlated to BMI, serum insulin levels, or the QUICKI index in either group. Furthermore, vaspin was negatively correlated to lipid parameters (total cholesterol, triglycerides, and low-density lipoproteins) in the pregnant but not in the non-pregnant women. Conclusions: Vaspin cannot serve as a marker of IR in either pregnant or non-pregnant women, although it is significantly correlated with adiponectin. On the other hand, vaspin might be useful as a surrogate marker of lipid metabolism in pregnancy if confirmed by subsequent studies.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 83%

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Serum vaspin levels in normal pregnancy in comparison with non-pregnant women

Giomisi

Kourtis

Toulis

et al. 2011

European Journal of Endocrinology

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“…However, other studies hold different opinions. Stepan et al suggest that serum vaspin level was not significantly different between GDM and non-GDM women, and serum vaspin level had no significant correlation with IR [17]. A recent report further suggest that vaspin level was positively correlated to IR and TG at the 3rd trimester of pregnancy but these correlations were not observed at the 2nd trimester or postpartum [18].…”

Section: Introductionmentioning

confidence: 96%

Serum vaspin levels and vaspin mRNA expression in subcutaneous adipose tissue in women with gestational diabetes mellitus

Qian

Fan

Khor

et al. 2014

European Journal of Obstetrics & Gynecology and Reproductiv

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“…Stepan et al [106] showed no significant difference in circulating vaspin concentration between GDM women and normal pregnancy. Furthermore, there was no correlation between vaspin level and parameters of insulin sensitivity or lipid metabolism in pregnant subjects.…”

Section: Vaspinmentioning

confidence: 95%

Związek hormonów pochodzących z tkanki tłuszczowej z cukrzycą ciążową (GDM)

Wójcik¹,

Chmielewska-Kassassir²,

Grzywnowicz³

et al. 2014

Endokrynologia Polska

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Gestational diabetes mellitus (GDM) is defined as a glucose intolerance of varying severity with onset or first recognition during pregnancy. The prevalence of GDM is growing rapidly worldwide, resulting in numerous and serious complications for both mother and foetus. Two major metabolic disorders, insulin resistance and β cells dysfunction, are currently linked to the pathogenesis of GDM, although the cellular mechanisms involved in the development of GDM are not yet completely understood. Increasing evidence from clinical and experimental studies indicates that adipose tissue dysfunction, characterised by abnormal production of adipokines, is an essential factor linked to insulin resistance and GDM. To date, several adipose tissue-derived hormones have been identified, including leptin, adiponectin, resistin, visfatin, apelin, retinol-binding protein 4 (RBP-4), vaspin, and omentin. The relationship of leptin and adiponectin to insulin resistance in GDM is relatively well documented, but the molecular mechanisms by which these hormones affect insulin resistance are not yet fully known. The other aforementioned adipokines appear to be also important players in the pathophysiology of GDM, although their precise function in this complex process remains to be established. The aim of this article is to review the literature concerning the relationship between the above-mentioned adipokines and GDM, and to clarify their role in the pathophysiology of GDM. Key words: adipokines; adiponectin; gestational diabetes mellitus (GDM); leptin; omentin; RBP-4; resistin; vaspin; visfatin StreszczenieCukrzyca ciążowa (GDM) jest definiowana jako nietolerancja glukozy, która po raz pierwszy wystąpiła lub została wykryta w czasie ciąży. Zachorowalność na GDM szybko wzrasta na świecie, prowadząc do licznych i poważnych powikłań zarówno u matki, jak i płodu. Dwa główne zaburzenia metaboliczne, czyli oporność na insulinę i dysfunkcja komórek b, biorą udział w patogenezie GDM, jednak komórkowe mechanizmy prowadzące do jej rozwoju nie są jeszcze do końca poznane. Wyniki badań klinicznych i eksperymentalnych wskazują, że dysfunkcja tkanki tłuszczowej, charakteryzująca się nieprawidłową produkcją adipokin, jest istotnym czynnikiem związanym z GDM. Do tej pory zidentyfikowano kilka hormonów wytwarzanych przez tkankę tłuszczową, w tym leptynę, adiponektynę, rezystynę, wisfatynę, apelinę, białko wiążące retinol 4 (RBP-4), waspinę i omentynę. Spośród nich stosunkowo dobrze udokumentowany jest związek leptyny i adiponektyny z insulinoopornością w GDM, ale molekularne mechanizmy działania obydwu hormonów w tym procesie nie są jeszcze całkowicie wyjaśnione. Pozostałe wyżej wymienione adipokiny wydają się być również istotnymi czynnikami w patofizjologii GDM, chociaż ich dokładna funkcja w tym kompleksowym procesie pozostaje niejasna. Celem niniejszego artykułu był przegląd istniejącej literatury dotyczącej związku między wyżej wymienionymi adipokinami i GDM oraz wyjaśnienie ich roli w patofizjologii GDM. (Endokrynol Pol 2014; 65 (2): 1...

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Preliminary report: circulating levels of the adipokine vaspin in gestational diabetes mellitus and preeclampsia

Cited by 33 publications

References 15 publications

Serum vaspin levels in normal pregnancy in comparison with non-pregnant women

Serum vaspin levels in normal pregnancy in comparison with non-pregnant women

Serum vaspin levels and vaspin mRNA expression in subcutaneous adipose tissue in women with gestational diabetes mellitus

Związek hormonów pochodzących z tkanki tłuszczowej z cukrzycą ciążową (GDM)

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