Preliminary reference intervals for cystatin C and beta-trace protein in preterm and term neonates

Bariciak, Erika; Yasin, Abeer; Harrold, JoAnn; Walker, Mark; Lepage, Nathalie; Filler, Guido

doi:10.1016/j.clinbiochem.2011.06.987

Cited by 51 publications

(45 citation statements)

References 21 publications

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“…Results obtained with the two main assays that are commercially available, namely the DAKO kit (turbidimetric, PETIA) and the Siemens Healthcare assay (nephelometric, PENIA), can be quite different, as recently demonstrated with the publication of reference intervals for healthy term and preterm infants. The results with the PENIA method in our study (79) were signifi cantly lower than those reported by Harmoinen et al (80) . Similar problems occurred when the results of the CKiD study were re-analyzed using PENIA, which lead to substantially better results (81) .…”

Section: Chromecontrasting

confidence: 57%

The usefulness of cystatin C and related formulae in pediatrics

Filler

Huang

Yasin

2012

Clinical Chemistry and Laboratory Medicine (CCLM)

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Serum creatinine does not share the properties of an ideal marker of glomerular fi ltration rate (GFR) like inulin, but continues to be the most widely used endogenous marker of GFR. In the search of a better biomarker of GFR, the small molecular weight protein cystatin C has been introduced with features more similar to that of inulin, such as constant production and no non-renal elimination. However, it has not enjoyed widespread use despite its signifi cantly improved diagnostic performance in the detection of impaired GFR and its independence of body composition. A variety of formulae based on either cystatin C or creatinine or both have been developed to estimate GFR. We summarize the currently used methods of GFR measurement, their limitations and analytical errors. The review also summarizes the history, features and the feasibility of cystatin C measurements as well as the most widely used formulae for the estimation of GFR in children. The diagnostic performance of the cystatin C derived eGFR formulae at various levels of GFR is also discussed. An eGFR formula derived from pooled studies analyzing both creatinine and cystatin C, and using a biology-based mathematical approach may be advantageous.

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Section: Chromecontrasting

confidence: 57%

The usefulness of cystatin C and related formulae in pediatrics

Filler

Huang

Yasin

2012

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…Several authors suggest that CysC does not cross the placenta [34][35][36], but recent evidence supporting the diaplacental transport of CysC has emerged [4,18], although the transport found was much less pronounced than that of serum Cr. Another potential low-molecular-weight protein marker is beta-trace protein (BTP) [37].…”

Section: Is Cysc the Best Marker Of Neonatal Renal Function?mentioning

confidence: 99%

“…Serum creatinine (Cr), the most widely used surrogate of GFR, is largely affected by maternal GFR. Cr crosses the placenta, and neonatal Cr has been shown to still strongly correlate with maternal creatinine 72 h after birth [17,18]. Cystatin C (CysC), a low-molecular-weight cysteine protease perpetually produced by all nucleated cells [19], has emerged as a promising alternative to serum Cr: it has been shown to have better diagnostic sensitivity [20] and to be independent of muscle mass [21] and body composition [22].…”

Section: Introductionmentioning

confidence: 99%

A step forward towards accurately assessing glomerular filtration rate in newborns

Filler

2015

Pediatr Nephrol

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In this edition of Pediatric Nephrology, Milena Treiber and colleagues have published a study on cystatin C (CysC) concentrations in relation to renal volumetry in 50 small-for-gestational age (SGA) and 50 appropriate-for-gestational age (AGA) neonates, deriving a new formula for estimating neonatal glomerular filtration rate (GFR). The study builds on previous work which established that renal volumetry together with CysC blood levels is a superior method for establishing GFR in term and pre-term newborns [The Journal of Pediatrics (2014) 164:1026-1031.e2]. Treiber et al. use the expected difference between SGA and AGA renal volumes to document the superiority of their new formula, which is based on total renal volume, CysC and body surface area, but does not incorporate gold-standard inulin clearance. Treiber et al.'s study adds new knowledge to the field that will hopefully improve the safety of renally excreted critical dose drugs in the newborn period. This editorial discusses the strengths and limitations of the current study.

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“…Therefore, estimations using its measured value should be interpreted carefully. Particularly in neonates, S-Cr levels immediately after birth do not adequately reflect renal function since maternal S-Cr crosses the placenta and influences neonatal serum levels [1][2][3]. In adults, serum cystatin C (S-CysC), which is less influenced by extrarenal factors, is being used as a sensitive biomarker for renal function [3,4].…”

Section: Introductionmentioning

confidence: 99%