Preliminary investigation on the environmental occurrence and effects of antibiotics used in aquaculture in Italy

Lalumera, Giorgia Mary; Calamari, D.; Galli, Paolo; Castiglioni, Sara; Crosa, Giuseppe; Fanelli, Roberto

doi:10.1016/j.chemosphere.2003.08.001

Cited by 272 publications

(129 citation statements)

References 19 publications

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“…Particularly, the concentration of DOC was high in all the detected samples although the detection frequency was much lower than that of most other antibiotics. The concentrations of the veterinary antibiotics in the estuarine sediments of the Bohai Sea are comparable to results reported from other study areas (Lalumera et al, 2004;Le and Munekage, 2004) as shown in Table 3. The average concentrations of OTC, TC and EFC were generally higher in the present study area than most other study areas.…”

supporting

confidence: 88%

Levels, distributions and sources of veterinary antibiotics in the sediments of the Bohai Sea in China and surrounding estuaries

Liu

Zhang

et al. 2016

Marine Pollution Bulletin

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Veterinary antibiotics are emerging contaminants of concern. A total of 139 samples comprising 104 marine sediments and 35 estuarine sediments were collected from the Bohai Sea area and analyzed for seventeen antibiotics. The results reveal that the presence and concentration of antibiotics were generally higher in the estuaries than in the sea. The highest antibiotic concentration, 4695 μg kg −1 of oxytetracycline, occurred in the estuarine sediment from Ziya New River. Bohai Bay and Laizhou Bay and the surrounding estuaries had higher concentrations of antibiotics. However, low levels of antibiotics detected were detected in Liaodong Bay in contrast to the high concentrations present in the surrounding estuaries. Spatial heterogeneity and principal component analysis suggest a large impact of terrestrial sources of the antibiotics contaminating the Bohai Sea. Risk quotients indicate that current levels of norfloxacin and oxytetracycline might be potentially hazardous to sensitive biota both in the Bohai Sea and in its surrounding estuaries.

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supporting

confidence: 88%

Levels, distributions and sources of veterinary antibiotics in the sediments of the Bohai Sea in China and surrounding estuaries

Liu

Zhang

et al. 2016

Marine Pollution Bulletin

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“…Apart from the potential for direct soil contamination, there is also the risk of run-off with heavy rain, thus potentially contaminating both the surround-ing surface and groundwater [42][43][44]. Other example of an anthropogenic activity is aquaculture, whose pharmaceuticals employed, as well as their metabolites and degradation prod-ucts, are directly discharged into surface waters [45,46]. Another important source of environmental contamination by pharma-ceuticals is the effluents of pharmaceutical production facilities [47][48][49].…”

Section: Sources Of Environmental Contaminationmentioning

confidence: 99%

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Santos

Araújo

Fachini

et al. 2010

Journal of Hazardous Materials

1,234

521

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Pharmaceuticals are biologically active and persistent substances which have been recognized as a con-tinuing threat to environmental stability. Chronic ecotoxicity data as well as information on the current distribution levels in different environmental compartments continue to be sparse and are focused on those therapeutic classes that are more frequently prescribed and consumed. Nevertheless, they indicate the negative impact that these chemical contaminants may have on living organisms, ecosystems and ultimately, public health. This article reviews the different contamination sources as well as fate and both acute and chronic effects on nontarget organisms. An extensive review of existing data in the form of tables, encompassing many therapeutic classes is presented.Keywords: Pharmaceuticals, Sources, Environmental fate, Ecotoxicological effects

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“…Given the high sorption coefficient of oxytetracycline of log Koc 4-5 l kg −1 (Rabølle and Spliid, 2000), dissipation towards the sediment would be expected, but this was not investigated by Schrap et al (2003). In another research, at the emission point of a tank-based aquaculture system for trout in northern Italy, a sediment concentration of 246 g kg −1 dry weight was found (Lalumera et al, 2004). This validation indicates that the surface water exposure model was not well founded, based on generalised data derived from situations that were not applicable.…”

Section: Fish Cultivationmentioning

confidence: 98%

Validation of the exposure assessment for veterinary medicinal products

Montforts

2006

Science of The Total Environment

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Under the EU Directive 2004/28/EC, an environmental risk assessment of new veterinary medicinal products is required. Given the nature of risk assessment for new applications, there is a need to model exposure concentrations. Critical evaluations are essential to ensure that the use of models by regulators does not result in the propagation of misleading information. The empirical validations of soil exposure models, previously discussed in this journal, indicate that it is impossible to analyse the contribution of every model parameter to the variability in the predictions. In particular, the prediction of the slurry concentration is challenged by uncertainties concerning dilution, mixing and dissipation of residues. Surface water and groundwater models generated highly deviating results compared to the field results, questioning the usefulness of the available screening models. Animal husbandry, slurry handling and environmental conditions throughout Europe are considered in order to define realistic worst case scenarios, to be used in conjunction with distribution models for the environmental risk assessment of veterinary medicinal products at registration. Given the variability in manure management practice throughout Europe, a deterministic approach for the manure-to-soil model was selected. Both worst case and best case scenario were developed. Several modelling assumptions applied in the surface water exposure model for fish nursery effluent were validated against newly available data. Since the available data give no proof that a settling tank contributes to the removal of pesticides from waste water, it is recommended for risk assessment purposes to consider the contribution of the settling tank to removal of pesticides and medicines to be negligible. Surface water dilution factors may be considered to be rather small, a factor of 2, for low flow situations.

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Preliminary investigation on the environmental occurrence and effects of antibiotics used in aquaculture in Italy

Cited by 272 publications

References 19 publications

Levels, distributions and sources of veterinary antibiotics in the sediments of the Bohai Sea in China and surrounding estuaries

Levels, distributions and sources of veterinary antibiotics in the sediments of the Bohai Sea in China and surrounding estuaries

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Validation of the exposure assessment for veterinary medicinal products

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