Preliminary investigation on prevalence of osteoporosis and osteopenia: Should we tune our focus on healthy adults?

Lee, Cathy Nga Yan; Lam, Simon Ching; Tsang, Alan Yat Kwan; Ng, Bernadette Ting Yan; Leung, Joyce; Chong, Andy Chun Yin

doi:10.1111/jjns.12063

Cited by 10 publications

(11 citation statements)

References 46 publications

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“…However, the frequencies reported in our study differ quite notably from those that have been reported in healthy adult cohorts in previously published studies. For one, our reported frequency of osteoporosis/ osteopenia (81.3 %) is notably different than that of normal asymptomatic adult populations of similar age ranges, which have previously been reported at 25.8-35 % [28,29]. Similarly, the rate of BMEP in our study population (100 %, with 31 % having severe BMEP) is notably higher than a Fig.…”

Section: Discussioncontrasting

confidence: 82%

“…Imaging pathology was typically manifest at the central weight-bearing surface of the medial femoral condyle. The high frequency of osteopenia or osteoporosis among our study population, especially in comparison to previously reported rates of osteopenia or osteoporosis in normal adult populations, supports that the impaired bone architecture along the load-bearing surfaces is likely a risk factor for insufficiency fracture [28,29]. However, the degree of abnormality (osteopenia versus osteoporosis) to predispose to fracture remains controversial [10,30].…”

Section: Discussionsupporting

confidence: 63%

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Femoral condyle insufficiency fractures: associated clinical and morphological findings and impact on outcome

et al. 2015

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Section: Discussioncontrasting

confidence: 82%

Section: Discussionsupporting

confidence: 63%

Femoral condyle insufficiency fractures: associated clinical and morphological findings and impact on outcome

et al. 2015

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“…; Lee et al . ). Energy and protein malnutrition have previously been reported to accelerate degradation to the hydroxyapatite matrix, possibly directly by lowered intake of amino acids ( e.g .…”

Section: Discussionmentioning

confidence: 97%

“…; Lee et al . ). Modelling suggests that the development of osteoporosis can be delayed by 13 years if a 10% higher peak bone mass is achieved in the third decade of life (Hernandez et al .…”

Section: Introductionmentioning

confidence: 97%

“…Clinical trials provide evidence of high rates of osteopenia in younger adults in both typical and clinically atypical population groups. In younger adults, the prevalence of abnormal BMD has been reported to range from 10.6-43.6% (D ıaz Curiel et al 2001;Liu et al 2008;Begum et al 2014;Lee et al 2015). Modelling suggests that the development of osteoporosis can be delayed by 13 years if a 10% higher peak bone mass is achieved in the third decade of life (Hernandez et al 2003).…”

Section: Introductionmentioning

confidence: 99%

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The effect of dietary interventions and nutritional supplementation on bone mineral density in otherwise healthy adults with osteopenia: A systematic review

et al. 2016

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There are many health and economic consequences for patients with osteopenia, the precursor to osteoporosis. A range of treatments may provide positive outcomes for otherwise healthy adults, including dietary and exercise approaches, either alone or in combination. The primary aim of this systematic review was to evaluate the effect of dietary approaches (including diet alone, diet with dietary supplements, both with or without physical activity intervention) on bone mineral density (BMD) to treat adults aged ≥18 years who were classified as having osteopenia. Six databases (Ovid MEDLINE including Ovid Medline in process, Cochrane Library, EMBASE, CINAHL Plus, Web of Science and Scopus) were searched systematically to identify randomised controlled trials of dietary approaches to treat osteopenic adults published from 1994 to November 2014. Study eligibility was determined, and included studies were assessed for risk of bias. Outcome data, particularly the primary outcomes of BMD T-and Z-scores or other measures of bone density, were combined narratively. The searches yielded 3511 papers, with three studies fulfilling the inclusion criteria. These studies included 254 participants, all free-living post-menopausal females with confirmed osteopenia. Vitamin D interventions were tested in all included studies, with none showing significant differences between intervention and placebo groups on BMD. This review has identified a lack of evidence to guide clinical practice in this area. Opportunities exist for future research to determine the effect of nonpharmacological approaches to osteopenia treatment in healthy populations, especially research that considers younger-aged and male populations, physical activity, habitual dietary intake and key bone health nutrients.

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Prevalence of osteoporosis and incidence of related fractures in developed economies in the Asia Pacific region: a systematic review

Chandran

Brind'Amour²,

Fujiwara

et al. 2023

Osteoporos Int

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Summary Robust data on osteoporosis in the Asia Pacific region could improve healthcare decision-making. Osteoporosis affects 10–30% of women aged 40 + , and up to 10% of men in 7 developed economies in Asia Pacific. Fractures affect 500–1000 adults aged 50 + per 100,000 person-years. Policymakers and clinicians must address this problem. Purpose Osteoporosis and associated fractures result in considerable morbidity, loss of productivity, early mortality, and increased healthcare expenses. Many countries in the Asia Pacific (AP) region, especially middle- and higher-income economies, are faced with aging and increasingly sedentary populations. It is critical to consolidate and analyze the available information on the prevalence and incidence of the disease in these countries. Methods We systematically reviewed articles and gray literature for Australia, China, Hong Kong, Japan, Singapore, South Korea, and Taiwan. We searched PubMed, ScienceDirect, JSTOR, Cochrane, Google Scholar, and other databases for data published 2009–2018. We included articles with prevalence or incidence estimates for adults with osteoporosis or related fractures. Results All locations had data available, but of widely varying quantity and quality. Most estimates for osteoporosis prevalence ranged from 10 to 30% for women ages 40 and older, and up to 10% for men. Osteoporotic fracture incidence typically ranged between 500 and 1000 per 100,000 person-years among adults aged 50 and older. Both outcomes typically increased with age and were more common among women. Conclusion Osteoporosis and associated fractures affect significant portions of the adult population in developed economies in the AP region. Governments and healthcare systems must consider how best to prevent and diagnose osteoporosis, and manage affected individuals, to reduce healthcare costs and mortality associated with fractures. Supplementary Information The online version contains supplementary material available at 10.1007/s00198-022-06657-8.

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Preliminary investigation on prevalence of osteoporosis and osteopenia: Should we tune our focus on healthy adults?

Abstract: High prevalence rate of abnormal BMD among healthy adults should be further studied in this population. The findings also suggest that the current ignorance in adulthood may increase the prevalence of osteoporotic fractures in the future.

Cited by 10 publications

References 46 publications

Femoral condyle insufficiency fractures: associated clinical and morphological findings and impact on outcome

Femoral condyle insufficiency fractures: associated clinical and morphological findings and impact on outcome

The effect of dietary interventions and nutritional supplementation on bone mineral density in otherwise healthy adults with osteopenia: A systematic review

Prevalence of osteoporosis and incidence of related fractures in developed economies in the Asia Pacific region: a systematic review

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