Preliminary in vitro studies on the Marsypianthes chamaedrys (boia-caá) extracts at fibrinoclotting induced by snake venoms

Effect of Annona senegalensis rootbark extracts on Naja nigricotlis nigricotlis venom in rats

“…Their active components bind to the venom proteins, in the process detoxifying the venom (Otero et al, 2000). These plants include: Diospyros kaki (Okonogi et al, 1979), Hemidesmus indicus (Alam et al, 1994), Eclipta prostrate (Melo et al, 1994;Pithayanuku et al, 2004), Brownea rosademonte (Otero et al, 2000), Bauhinia cumanensis, Cecropia peltata, Aristolochia rugusa, Pithocellobium unguis-cati, Cola nitida, Renealmia alpine (Lans et al, 2001), Alocasia cucullata (Wang, 1986), Cissus assamica, Aristolochia fordiana (Wang et al, 1997), Marsypianthes chamaedrys (Castro et al, 2003), Guiera senegalensis (Abubakar et al, 2000) and Harpalyce brasiliana (Silva et al, 1997).…”

Plants used to treat snakebites in Santarém, western Pará, Brazil: An assessment of their effectiveness in inhibiting hemorrhagic activity induced by Bothrops jararaca venom

“…Of these, 17 (70.8 %) had not been previously reported as having anti-snakebite properties and only the following 7 (29.1 %) had already been the subject of scientific studies proving their anti-snakebite properties: Kalanchoe brasiliensis (Fonseca et al, 2004), Marsypianthes chamaedrys (Castro et al, 2003;Magalhães et al, 2011), Plathymenia reticulata (Farrapo et al, 2010;, Connarus favosus, Philodendron megalophyllum, Aniba fragrans and Bellucia dichotoma (Moura et al, 2014). that all the extracts contained more condensed than hydrolyzable tannins.…”

Inhibition of the inflammatory and coagulant action of Bothrops atrox venom by the plant species Marsypianthes chamaedrys

“…In the crushed plant, such compounds are probably responsible for the anticoagulant activity observed in the PT test, which is related to a greater affinity for the tissue factor pathway (factors II, V, VII and X). Castro et al (2003) showed that the aqueous extract of Marsypianthes chamaedrys and its methanolic fraction were able to neutralize the fibrinogenolytic activity of Bothrops jararaca venom and thrombin and suggested that the effect observed may be the result of direct action on serine proteases similar to thrombin and on thrombin itself. Two specific components of the coagulation system act as links between inflammation and coagulation of the blood: thrombin, which cleaves fibrinogen into fibrin, and factor Xa, which causes an increase in vascular permeability after it has bound to its 2 Previously referred to as the intrinsic pathway.…”