Preliminary Findings for Preemptive Analgesia with Inhaled Morphine: Efficacy in Septoplasty and Septorhinoplasty Cases

Abstract

B-3b.

Inhaled opioids for cancer pain relief

“…It was noted that the first analgesia requirement emerged significantly later in the nebulized morphine group that is231.72 versus 48.75 minutes. No significant difference was detected between the frequency of postoperative nausea or vomiting [28] …”

“…However, 7 patients in the nebulized morphine group required additional diazepam because of restlessness [27] . Other authors have shown the possible efficacy of nebulized morphine in pre-emptive analgesia before septoplasty or septorhinoplasty [28] . In their double-blind RCT, Onal et al randomized 80 patients to either nebulized 65 μg/kg morphine or nebulized saline [28] .…”

“…No significant difference was detected between the frequency of postoperative nausea or vomiting. [28] As mentioned earlier, nebulized morphine pharmacokinetics depend significantly on the type of nebulizer used. The studies mentioned above exclusively employed jet nebulizers which produce low serum morphine concentrations.…”

“…[27] Other authors have shown the possible efficacy of nebulized morphine in pre-emptive analgesia before septoplasty or septorhinoplasty. [28] In their double-blind RCT, Onal et al randomized 80 patients to either nebulized 65 mg/kg morphine or nebulized saline. [28] Nebulization, delivered by a jet nebulizer, was performed 10 minutes prior to induction.…”

“…[28] In their double-blind RCT, Onal et al randomized 80 patients to either nebulized 65 mg/kg morphine or nebulized saline. [28] Nebulization, delivered by a jet nebulizer, was performed 10 minutes prior to induction. It was noted that the first analgesia requirement emerged significantly later in the nebulized morphine group that is231.72 versus 48.75 minutes.…”