Preliminary evaluation of therapeutic ion release from Sr-doped zinc-silicate glass ceramics

Looney, Mark G.; O’Shea, Helen; Boyd, Daniel

doi:10.1177/0885328211413621

Cited by 12 publications

(8 citation statements)

References 51 publications

(60 reference statements)

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“…This is the case for example with Sr 2+ replacing Ca 2+ cations, a privileged mechanism in the present work. The total amount of strontium released in solution after incubation for 5 days in TRIS-HCl is within therapeutic range (0–547 ppm) 9, 62, 63 and was similar between glasses and glass-ceramics subjected to sintered cycle (Figure 6B). The linear increase in strontium released in solution with the amount of strontium present in the glass composition may offer a simple approach to in situ delivery of controlled strontium doses, with different levels of release tailored by composition and degree of crystallization.…”

Section: Discussionmentioning

confidence: 67%

Strontium‐releasing fluorapatite glass‐ceramics: Crystallization behavior, microstructure, and solubility

et al. 2017

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The purpose of this work was to investigate the effect of strontium partial replacement for calcium on the crystallization behavior, microstructure and solubility of fluorapatite glass-ceramics. Four glass compositions were prepared with increasing amounts of strontium partially replacing calcium. The crystallization behavior was analyzed by differential scanning calorimetry and X-ray diffraction (XRD). The microstructure was investigated by scanning electron microscopy. The chemical solubility was quantified according to ISO standard 10993-14. The amount of strontium released in solution after incubation in TRIS-HCl or citric acid buffer was measured by atomic absorption spectroscopy. XRD analyses revealed that partially substituted strontium-fluorapatite and strontium-åkermanite crystallized after strontium additions. The lattice cell volume of both phases increased linearly with the amount of strontium in the composition. Strontium additions led to a reduction in crystal size and an increase in crystal number density. The chemical solubility and amount of strontium released in solution increased linearly with the amount of strontium present in the composition in both TRIS-HCl and citric acid buffers. Total amounts of strontium released reached a maximum of 547 ± 80 ppm in TRIS-HCl and 1252 ± 290 ppm in citric acid buffer for the glass composition with the highest amount of strontium. For all strontium-containing compositions, the amount released in TRIS-HCl continued to increase between 70 and 120 h, indicating sustained release rather than burst release. © 2017 Wiley Periodicals, Inc. J Biomater Res Part B: 106B: 1421-1430, 2018.

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Section: Discussionmentioning

confidence: 67%

Strontium‐releasing fluorapatite glass‐ceramics: Crystallization behavior, microstructure, and solubility

et al. 2017

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“…In this study, the zinc concentration range in the culture medium was from 0 to 0.59±0.03 mg −1 which was confirmed to be non-toxic and expected to promote bone growth in vivo. Looney et al [59] prepared a series of strontium-doped zinc silicate (Ca-Sr-Na-Zn-Si) glass ceramic scaffolds with a porosity of 93% -96%. After dissolution in Tris-HCl, the levels of Zn 2+ detected as a result of the degradation of the crystalline phases were found to be 1.4 -600 parts per million.…”

Section: Scaffoldsmentioning

confidence: 99%

Zinc-containing bioactive glasses for bone regeneration, dental and orthopedic applications

Balasubramanian¹,

Strobel²,

Kneser³

et al. 2015

Biomedical Glasses

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Zinc is a vital and beneficial trace element found in the human body. Though found in small proportions, zinc performs a variety of functions in relation to the immune system, cell division, fertility and the body growth and maintenance. In particular, zinc is proven to be a necessary element for the formation, mineralization, development and maintenance of healthy bones. Considering this attractive attributes of zinc, recent research has widely focused on using zinc along with silicate-based bioactive glasses for bone tissue engineering applications. This paper reviews relevant literature discussing the significance of zinc in the human body, along with its ability to enhance antibacterial effects, bioactivity and distinct physical, structural and mechanical properties of bioactive glasses. In this context, even if the present analysis is not meant to be exhaustive and only representative studies are discussed, literature results confirm that it is essential to understand the properties of zinc-containing bioactive glasses with respect to their in vitro biological behavior, possible cytotoxic effects and degradation characteristics to be able to effectively apply these glasses in bone regeneration strategies. Topics attracting increasing research efforts in this field are elaborated in detail in this review, including a summary of the structural, physical, biological and mechanical properties of zinc-containing bioactive glasses. This paper also presents an overview of the various applications in which zinc-containing bioactive glasses are considered for use as bone tissue scaffolds, bone filling granules, bioactive coatings and bone cements, and advances and remaining challenges are highlighted.

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“…11 The zinc-silicate glass cements were modified to incorporate strontium, which can inhibit bone resorption and stimulate bone formation. [21][22][23][24] The inherently radio-opaque cements were found to have therapeutic release of Zn 2þ and Sr 2þ , as well as enhanced cell viability in vitro. 25 Thus, cements with many desirable traits for orthopedic applications were achieved, but were not clinically relevant due to their poor handling properties.…”

Section: Introductionmentioning

confidence: 99%

Calcium polyphosphate as an additive to zinc-silicate glass ionomer cements

et al. 2015

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Aluminum-free glass ionomer cements (GICs) are under development for orthopedic applications, but are limited by their insufficient handling properties. Here, the addition of calcium polyphosphate (CPP) was investigated as an additive to an experimental zinc-silicate glass ionomer cement. A 50% maximum increase in working time was observed with CPP addition, though this was not clinically significant due to the short working times of the starting zinc-silicate GIC. Surprisingly, CPP also improved the mechanical properties, especially the tensile strength which increased by ∼33% after 30 days in TRIS buffer solution upon CPP addition up to 37.5 wt%. This strengthening may have been due to the formation of ionic crosslinks between the polyphosphate chains and polyacrylic acid. Thus, CPP is a potential additive to future GIC compositions as it has been shown to improve handling and mechanical properties. In addition, CPP may stimulate new bone growth and provide the ability for drug delivery, which are desirable modifications for an orthopedic cement.

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Preliminary evaluation of therapeutic ion release from Sr-doped zinc-silicate glass ceramics

Cited by 12 publications

References 51 publications

Strontium‐releasing fluorapatite glass‐ceramics: Crystallization behavior, microstructure, and solubility

Strontium‐releasing fluorapatite glass‐ceramics: Crystallization behavior, microstructure, and solubility

Zinc-containing bioactive glasses for bone regeneration, dental and orthopedic applications

Calcium polyphosphate as an additive to zinc-silicate glass ionomer cements

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