Calcium polyphosphate as an additive to zinc-silicate glass ionomer cements

Valliant, Esther M.; Gagnier, David; Dickey, Brett; Boyd, Daniel; Filiaggi, Mark

doi:10.1177/0885328215568985

Cited by 7 publications

(3 citation statements)

References 44 publications

(87 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1-3 min) of these cements renders them impractical for PVP, as they are not injectable. 3,[8][9][10] A common philosophy that has been investigated in the literature to improve the handling characteristics of zinc-silicate GICs is to vary the network modifier and/or intermediate content of the glass in an effort to control degradability. 3,[11][12][13] However, this approach has yet to produce a GIC that combines the requisite handling characteristics (minimum working times of 5-10 min) with sufficient levels of strength (compression strengths > 30 MPa).…”

Section: Introductionmentioning

confidence: 99%

Exploring the unexpected influence of the Si:Ge ratio on the molecular architecture and mechanical properties of Al-free GICs

2016

Self Cite

View full text Add to dashboard Cite

Germanium (Ge)-based glass ionomer cements have demonstrated the ability to balance strength with extended setting times, a unique set of characteristics for aluminum-free glass ionomer cements. However, the mechanical properties of current Ge-based glass ionomer cements significantly deteriorate over time, which jeopardizes their clinical potential. This work explores the effect of incrementally decreasing the Si:Ge ratio in the glass phase of zinc-silicate glass ionomer cements to identify potential mechanisms responsible for the time-induced mechanical instability of Ge-based glass ionomer cements. The influence of Ge was evaluated on the basis of changes in mechanical properties and molecular architecture of the cements over a 180-day period. It was observed that the compressive strength and modulus of the cements were sustained when Si:Ge ratios were ≥1:1, but when Si:Ge ratios are <1:1 these properties decreased significantly over time. These mechanical changes were independent of structural changes in the glass ionomer cement matrices, as the level of metal-carboxylate crosslinks remained constant over time across the various Si:Ge ratios explored. However, it was noted the temporal decline of mechanical properties was proportional to the increased release of degradation byproducts, in particular Ge that was released from the cements in substantially greater quantities than other glass constituents. Unexpectedly, the slowest setting cement (Si:Ge 1:1) was also the strongest; behavior that is uncommon in Si-based glass ionomer cements, supports the potential of Ge-containing glass ionomer cements as injectable bone cements in applications such as percutaneous vertebroplasty.

show abstract

Section: Introductionmentioning

confidence: 99%

Exploring the unexpected influence of the Si:Ge ratio on the molecular architecture and mechanical properties of Al-free GICs

2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…In future study, we will conduct biaxial flexural tension test and failure test for our SPC + VT composite, which is meaningful to evaluate its potential use as load‐bearing bone scaffold . Moreover, Fourier transform infrared spectroscopy will be included in future experiment to clarify the reaction mechanism among CPP, PMMA, and antibiotics …”

Section: Discussionmentioning

confidence: 99%

Release of vancomycin and tobramycin from polymethylmethacrylate cements impregnated with calcium polyphosphate hydrogel

et al. 2017

View full text Add to dashboard Cite

The influence of calcium polyphosphate (CPP) gel incorporation on the release of vancomycin and tobramycin from polymethyl methacrylate (PMMA) cement (Simplex P, SP) has been studied. Adding 10% CPP gel to SP led to a much lower burst release of vancomycin and considerably extended release of both vancomycin and tobramycin up to 24 weeks. Antibiotics released from this new material retain their bactericidal activity for up to 15 weeks. The improvement in the antibiotic release is mainly due to the molecular interactions of antibiotics with embedded CPP polyphosphate chains as confirmed by Raman spectroscopy analysis. The inclusion of CPP hydrogel also increased the SP surface roughness and pore sizes, leading to a higher release rate of antibiotics. The new material is biocompatible and has similar handling properties and mechanical strength as compared to SP cements. We believe that incorporating CPP gel provides a better and usable drug carrier for PMMA cement. © 2017 The Authors Journal of Biomedical Materials Research Part B: Applied Biomaterials Published by Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2827-2840, 2018.

show abstract

“…25 To determine whether EM-P can be used for the repair of load-bearing bone defects, the potential impacts of EM-P on the flexural modulus and flexural strength warrants further investigation. 46 DCPD has been proposed as an alternative to PMMA for local antibiotic delivery. 10 Many studies have aimed at improving DCPD's ability to deliver antibiotics in a sustained pattern but these have had limited success.…”

Section: Cellular Responsementioning

confidence: 99%

Properties of erythromycin‐loaded polymeric dicalcium phosphate dehydrate bone graft substitute

Guardia

Shi

Bou‐Akl

et al. 2021

Journal Orthopaedic Research

View full text Add to dashboard Cite

A self-setting, injectable polymeric dicalcium phosphate dehydrate bone graft substitute that is mechanically strong and has excellent cohesion was developed.We assessed the performance of erythromycin-loaded polymeric dicalcium phosphate dehydrate cement. Its properties include drug release, growth inhibition against Staphylococcus aureus and biocompatibility with osteoblastic MC3T3 cells.The impact of erythromycin loading on cement injectability, setting time, and mechanical strength were also evaluated. A sustained, low burst release of erythromycin was observed. Eluents collected from erythromycin-loaded cement showed a considerable zone of inhibition for up to 28 days. Direct contact of erythromycin-loaded cement discs with agar plate showed a similarly sizable zone of inhibition for up to 22 days. Degraded ceramic residues had strong zones of inhibition as well. While the erythromycin-loaded cement was injectable, a notable delay of the setting time was observed (49.2 ± 6.8 min) as compared with control (drug-free cement, 12.2 ± 2.6 min). A slight increase in compressive strength (60.83 ± 6.28 MPa) was observed in erythromycin-loaded cement as compared with control (59.41 ± 6.48 MPa). Erythromycin-loaded cement was biocompatible although reduced cell growth was observed in the presence of the cement eluent.We propose that the bactericidal efficacy of erythromycin-loaded cement was caused by the combined effects of erythromycin released and exposed on the contact surface of degrading ceramics. Our data may elucidate the future application of polymeric dicalcium phosphate dehydrate bone graft substitute for the treatment of orthopedic infections and opportunities to use other antibiotics and applications considering its comparable handling and mechanical strength to poly (methyl methacrylate) cements.

show abstract

Calcium polyphosphate as an additive to zinc-silicate glass ionomer cements

Cited by 7 publications

References 44 publications

Exploring the unexpected influence of the Si:Ge ratio on the molecular architecture and mechanical properties of Al-free GICs

Exploring the unexpected influence of the Si:Ge ratio on the molecular architecture and mechanical properties of Al-free GICs

Release of vancomycin and tobramycin from polymethylmethacrylate cements impregnated with calcium polyphosphate hydrogel

Properties of erythromycin‐loaded polymeric dicalcium phosphate dehydrate bone graft substitute

Contact Info

Product

Resources

About