Preliminary assessment of Rosmarinus officinalis toxicity on male Wistar rats' organs and reproductive system

Sá, Rita de Cássia da Silveira e; Leite, Magda Narciso; Oliveira, Leandra; Toledo, Melina M.; Greggio, Tânia C.; Guerra, Martha O.

doi:10.1590/s0102-695x2006000300008

Cited by 6 publications

(1 citation statement)

References 37 publications

(32 reference statements)

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“…Therefore, we deduced that Origanum extract did not offer nor a stimulatory neither inhibitory effect with respect to oxidative stress. Sá et al (2006) in their study analysed the effect of short-term administration of Origanum officinalis water extract on vital organs, organs of the reproductive system and on production of sperm of male Wistar rats. Adult males (90 days) weighing approximately 250 g, were randomly divided into three experimental groups.…”

Section: Resultsmentioning

confidence: 99%

The in Vitro Effect of the Origanum Vulgare Extract on Semen

Ďuračka¹

2019

J microb biotech food sci

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Origanum vulgare is a medicinal and aromatic plant that has found its use all over the world. Male reproduction involves complicated morphological and physiological processes such as spermatogenesis and gamete transport into the male genital organs. The aim of this study is focused on the in vitro effect of the Origamium vulgaris on the motility, vitality and evaluation of the formation of free radicals. The heterospermic rabbit samples were diluted with culture medium supplemented with the extract of Origamium vulgaris at concentrations of 37.5; 75; 150 and 300 μg/mL evaluated at time intervals of 0, 2 and 8h. Selected chemical compounds were determined through HPLC-DAD method. From the analysed phenolic acids, rosmarinic acid was the predominant component, from flavonoids it was Cynarosid. Sperm motility was analysed using CASA (Computer-aided Sperm Analysis). The viability was analysed by the MTT (Mitochondrial Toxicity Test) test. The determination of ROS (Reactive Oxygen Species) quantity was observed through luminol method. The results showed significant decreases of motility and viability at concentrations of 300 and 150 μg/mL in various time periods and the ROS quantity was without any significant differences during all the experiment. We conclude that chemical composition of the Origanum extract may damage structure and function of spermatozoa. Based on this findings, we did not suggest the Origanum extract as a supplement in spermatozoa medium.

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Section: Resultsmentioning

confidence: 99%

The in Vitro Effect of the Origanum Vulgare Extract on Semen

Ďuračka¹

2019

J microb biotech food sci

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Ethnobotanical, pharmacological, phytochemical, and clinical investigations on Moroccan medicinal plants traditionally used for the management of renal dysfunctions

Noureddine

Elachouri

Mandal

2022

Journal of Ethnopharmacology

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Atividade antibacteriana de óleos essenciais de plantas frente a linhagens de Staphylococcus aureus e Escherichia coli isoladas de casos clínicos humanos

Silva

Ushimaru

Barbosa

et al. 2009

Rev. bras. plantas med.

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A ação antibacteriana in vitro de óleos essenciais de seis plantas foi verificada por meio da Concentração Inibitória Mínima (CIM=%v/v) pela diluição dos óleos em meio de cultura Mueller Hinton Agar, frente a linhagens de Staphylococcus aureus (n=16) e Escherichia coli (n=16) isoladas de casos clínicos humanos, além de 1 amostra padrão ATCC para cada espécie (Sa ATCC 25923 e Ec ATCC 25922), e determinação de curvas de sobrevivência em concentrações equivalentes a CIM90% dos respectivos óleos. O óleo essencial de canela foi o mais eficiente, com valores de CIM90% de 0,047 e 0,09 para S. aureus e E. coli respectivamente, enquanto gengibre (0,09), cravo da índia (0,095) e capim cidreira (0,1) apresentaram eficiências semelhantes para S. aureus. Frente a E. coli, os óleos de gengibre (0,52) e capim cidreira (0,55) foram equivalentes quanto à eficiência. De acordo com as curvas de sobrevivência, foi possível verificar também que os valores de CIM90% obtidos podem ser tanto bactericidas ou bacteriostáticas de acordo com a bactéria testada. Em conclusão, verificou-se que os óleos essenciais testados foram efetivos no controle do desenvolvimento bacteriano, sendo o potencial antimicrobiano diferente em função da espécie bacteriana testada, sendo que a bactéria Gram positiva (S. aureus) mostrou-se mais susceptível aos óleos testados que a Gram negativa (E. coli).

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Preliminary assessment of Rosmarinus officinalis toxicity on male Wistar rats' organs and reproductive system

Cited by 6 publications

References 37 publications

The in Vitro Effect of the Origanum Vulgare Extract on Semen

The in Vitro Effect of the Origanum Vulgare Extract on Semen

Ethnobotanical, pharmacological, phytochemical, and clinical investigations on Moroccan medicinal plants traditionally used for the management of renal dysfunctions

Atividade antibacteriana de óleos essenciais de plantas frente a linhagens de Staphylococcus aureus e Escherichia coli isoladas de casos clínicos humanos

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