Preliminary assessment of fluorine-18 fluorodeoxyglucose positron emission tomography in patients with bladder cancer

Kosuda, Shigeru; Kison, Paul V.; Greenough, Robert B.; Grossman, H. Barton; Wahl, Richard L.

doi:10.1007/s002590050095

Cited by 45 publications

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“…We noted a maximum SUV range of 2.3 to 7.8, which is in general agreement with a prior report that reported SUV ranges of 2.2-6.2 for the primary tumor and 1.7 to 4.8 for lymph node metastases. 4 In an earlier rat bladder tumor model, a high tumor-toblood FDG uptake ratio of 22 was noted. 3 Therefore, unless the tumor deposits are adjacent to very high urine activity or the lesions are small (below the spatial resolution of the PET camera system), one expects that TCC will be detected.…”

Section: Discussionmentioning

confidence: 99%

[F-18]-Fluorodeoxyglucose PET and PET-CT in diagnostic imaging evaluation of locally recurrent and metastatic bladder transitional cell carcinoma

et al. 2008

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Background-Little data is available on the utility of positron emission tomography (PET) and positron emission tomography-computed tomography (PET-CT) with [F-18]-fluorodeoxyglucose (FDG) in patients with bladder cancer. We retrospectively assessed the diagnostic utility of dedicated PET and hybrid PET-CT scans with [F-18]-FDG in the imaging evaluation of recurrent and metastatic bladder transitional cell carcinoma.

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Section: Discussionmentioning

confidence: 99%

[F-18]-Fluorodeoxyglucose PET and PET-CT in diagnostic imaging evaluation of locally recurrent and metastatic bladder transitional cell carcinoma

et al. 2008

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“…Development of this examination for the staging of urothelial tumours appears to be warranted because of the high affinity of these tumors for FDG. 13 However, one of the major drawbacks is that 18 F-FDG is excreted in the urine and can therefore interfere with interpretation of the examination as a result of the increased uptake related to this physiological excretion in the urine and therefore in the bladder. Similarly, the intimate anatomi- …”

Section: Discussionmentioning

confidence: 99%

¹⁸F‐fluorodeoxyglucose positron emission tomography–computed tomography for preoperative lymph node staging in patients undergoing radical cystectomy for bladder cancer: A prospective study

Hitier-Berthault¹,

Ansquer

Branchereau³

et al. 2012

Int J of Urology

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Abbreviations & AcronymsObjectives: The objective of our study was to analyze the diagnostic performance of 18 F-fluorodeoxyglucose positron emission tomography-computed tomography for lymph node staging in patients with bladder cancer before radical cystectomy and to compare it with that of computed tomography. Methods: A total of 52 patients operated on between 2005 and 2010 were prospectively included in this prospective, mono-institutional, open, non-randomized pilot study. Patients who had received neoadjuvant chemotherapy or radiotherapy were excluded. 18 F-fluorodeoxyglucose positron emission tomography-computed tomography in addition to computed tomography was carried out for lymph node staging of bladder cancer before radical cystectomy. Lymph node dissection during radical cystectomy was carried out. Findings from 18 F-fluorodeoxyglucose positron emission tomography-computed tomography and computed tomography were compared with the results of definitive histological examination of the lymph node dissection. The diagnostic performance of the two imaging modalities was assessed and compared. Results: The mean number of lymph nodes removed during lymph node dissection was 16.5 Ϯ 10.9. Lymph node metastasis was confirmed on histological examination in 22 cases (42.3%). This had been suspected in five cases (9.6%) on computed tomography and in 12 cases (23.1%) on 18 F-fluorodeoxyglucose positron emission tomographycomputed tomography. Sensitivity, specificity, positive predictive value, negative predictive value, relative risk and accuracy were 9.1%, 90%, 40%, 57.4%, 0.91 and 55.7%, respectively, for computed tomography, and 36.4%, 86.7%, 66.7%, 65%, 2.72, 65.4%, respectively, for 18 F-fluorodeoxyglucose positron emission tomography-computed tomography. Conclusions:18 F-fluorodeoxyglucose positron emission tomography-computed tomography is more reliable than computed tomography for preoperative lymph node staging in patients with invasive bladder carcinoma undergoing radical cystectomy.

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“…In fact, whereas glucose is completely reabsorbed in the proximal tubules of the kidney, 18 F-FDG is not, resulting in excretion of radioactivity in the urine (1,2). The accumulation of 18 F-FDG activity through the urinary system can be mistaken for focal uptake that is due to oncologic processes, and this physiologic accumulation can interfere with the diagnostic evaluation of the abdominal and pelvic regions even if the patients empty their bladders before the scan (3)(4)(5)(6). Many investigators have demonstrated that hydration and the use of diuretics can eliminate these effects (7)(8)(9)(10)(11)(12).…”

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confidence: 99%

Could Different Hydration Protocols Affect the Quality of 18F-FDG PET/CT Images?

Ceriani

Suriano²,

Ruberto³

et al. 2011

Journal of Nuclear Medicine Technology

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In a group of oncologic patients undergoing 18 F-FDG PET/CT, we compared 4 different protocols of hydration to investigate their impact on image quality and to choose the best practice. Methods: One hundred twenty subjects undergoing 18 F-FDG PET/CT were randomized into 4 groups: group A, receiving free oral hydration; group B, receiving an intravenous injection of 10 mg of furosemide and infusion of 500 mL of saline solution starting 5 min after tracer injection; group C, receiving oral hydration with 500 mL of water; and group D, receiving intravenous injection of 10 mg of furosemide and infusion of 250 mL of the saline solution starting 30 min after the 18 F-FDG injection. The maximum standardized uptake value of muscular and adipose tissues, blood pool (aortic and left ventricular cavity), bladder, and renal parenchyma was calculated for each subject. Results: These 4 groups were comparable in age, body mass index, blood glucose level, and serum creatinine level. Group A showed the worst results. The controlled hydration protocols (groups B, C, and D) provided lower background activity in the soft tissues and lower urinary activity in the bladder and kidney without significant differences in blood activity. The administration of furosemide produces lower activity in the urinary tract without significant changes in 18 F-FDG distribution in the muscle, fat, or blood pool. The best results were in group D. Conclusion: Controlled hydration, particularly with standardized parenteral protocols, reduces the background activity in the soft tissues with the potential benefit of increasing the tumor-to-background contrast. Furosemide does not change tracer distribution in normal tissues but improves the quality of PET/CT images, reducing activity in the excretory system, particularly if the furosemide is administered late after 18 F-FDG injection.

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Preliminary assessment of fluorine-18 fluorodeoxyglucose positron emission tomography in patients with bladder cancer

Cited by 45 publications

References 0 publications

[F-18]-Fluorodeoxyglucose PET and PET-CT in diagnostic imaging evaluation of locally recurrent and metastatic bladder transitional cell carcinoma

[F-18]-Fluorodeoxyglucose PET and PET-CT in diagnostic imaging evaluation of locally recurrent and metastatic bladder transitional cell carcinoma

¹⁸F‐fluorodeoxyglucose positron emission tomography–computed tomography for preoperative lymph node staging in patients undergoing radical cystectomy for bladder cancer: A prospective study

Could Different Hydration Protocols Affect the Quality of 18F-FDG PET/CT Images?

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Preliminary assessment of fluorine-18 fluorodeoxyglucose positron emission tomography in patients with bladder cancer

Cited by 45 publications

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[F-18]-Fluorodeoxyglucose PET and PET-CT in diagnostic imaging evaluation of locally recurrent and metastatic bladder transitional cell carcinoma

[F-18]-Fluorodeoxyglucose PET and PET-CT in diagnostic imaging evaluation of locally recurrent and metastatic bladder transitional cell carcinoma

18F‐fluorodeoxyglucose positron emission tomography–computed tomography for preoperative lymph node staging in patients undergoing radical cystectomy for bladder cancer: A prospective study

Could Different Hydration Protocols Affect the Quality of 18F-FDG PET/CT Images?

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¹⁸F‐fluorodeoxyglucose positron emission tomography–computed tomography for preoperative lymph node staging in patients undergoing radical cystectomy for bladder cancer: A prospective study